Pantothenic Acid Helped With Gut Troubles

[Giraffe]

I had a phase where I could not tolerate any solid food. Since then I had for months repeatedly digestive issues often including abdominal pains, lower back pains, nausea, headaches. The list of safe foods had become very short, and minor insults caused unusual trouble.

Lack of pantothenic acid seems to compromise gut health, there are issues with the adrenals, and it is needed to deactivate insulin (along with riboflavin). Since you find it in all foods, it is thought that deficiency is very rare, but maybe this is not true for people who have digestive issues already and therefore have difficulties to absorb nutrients.

Two months ago I took about 200mg pantothenic acid. I could feel almost immediately that a tense area in the lower abdomen relaxed. I kept the dose for a couple of weeks, but then started to forget it. I supplement once in a while now. I haven't had any issues since.
.........

As a side note:

My understanding is that Ray Peat seldom advises to supplement pantothenic acid, better to try to get it from nutrient-rich foods.

He has mentioned pantothenic acid in one of the herbdoctor shows. He said that a raised metabolic rate raises the requirements for nutrients, and if you "try to run on too much coffee and sugar and not enough food", you are likely to run out of vitamins and minerals, "biotin and vitamin B6 and pantothenic acid, selenium and copper are things that are among the first to become deficient".

Sugar Myths 2 (2011)

 

[Amazoniac]

Thanks for sharing your experience.
Index of /research-PDFs

 

[Amazoniac]

First file is working and also "borrowing":
Overcoming the pain of inflammatory arthritis : the pain-free promise of pantothenic acid : Eisenstein, Phyllis, 1946- : Free Download & Streaming : Internet Archive

 

[Amazoniac]

It makes no sense to allow only one person at a time to borrow an online book.
Here are some concerning parts:

 

[Amazoniac]

 

[Amazoniac]

@DaveFoster @haidut

 

[Amazoniac]

With arthritis in mind:

 

[Zpol]

Nice! thanks Amazoniac!

 

[Broken man]

I think that when I am eating 3-4 eggs every day, I cant be deficient or I am wrong? What about this? Patent US5360821 - Method of use of pantothenic acid to improve the athletic performance and sense of well being of a human being Its about Coenzyme A and that its important for steroids.... and great against lupus? Systemic lupus erythematosus: a combined deficiency disease - ScienceDirect
@Giraffe how much vit D are you taking? Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with atherosclerosis and autoimmunity - ScienceDirect
Please @haidut, @DaveFoster, @Constatine, @TubZy ?
Could I be deficient because I am using 2 g+ of taurine and

However, it seems that their similar structure makes them deplete each other in the tissues

. What I saw is that pantothenic acid is made from Beta alanine and pantoic acid.

 

[Amazoniac]

The influence of single and multiple B complex deficiencies upon the motility of the gastro-intestinal tract

"From a consideration of the radiological findings it is our opinion that in each of the sets, other than set 5 (which received both inositol and pantothenic acid) there are features in common suggesting that the two factors, inositol and pantothenic acid, are both associated with the maintenance of gastro-intestinal normalcy. That other factors, such as pyridoxine, may influence the general picture is illustrated by the hypotonicity of sets 1 and 4. The striking similarity of pantothenic acid and inositol deficiencies in their effect on the gastro-intestinal tract is to be emphasized and suggests the presence of an interdependence of the two factors. The same features characterize the picture if either is absent from the diet. These features are:
1. Increased gastric emptying time with pylorospasm.
2. Marked segmentation of both the small and the
large intestine.
3. General picture of hypertonicity with hypomotility.
4. Alternation of ribbon-like segments with dilated
loops.
5. Frequent formation of gas.
6. Fluid levels."

"Calcium pantothenate deficiency has been produced in dogs by several groups of workers. Morgan and Simms (12) noted bloody diarrhea in their dogs on diets deficient in filtrate factors. McKibbin et al (13) tried an experiment supplying pyridoxine, as well as thiamine, riboflavin, and nicotinic acid along with the purified diet. They found that pantothenic acid and another alkali labile factor, as well as factor W, were needed for growth of young mongrel puppies. The test periods were short, and they reported no gastro-intestinal abnormalities. Fours et al (14) gave supplements of thiamine, riboflavin, nicotinic acid and pyridoxine and found that all their animals developed diarrhea within 7 to 66 days. It was intermittent in character but became severe and often bloody before death. Decrease in appetite was especially marked during exacerbations of diarrhea. Vomiting occurred frequently. At autopsy the liver of each dog appeared to be fatty. One animal had superficial ulcerations of the gums, another had numerous shallow ulcers and hemorrhages in the ileum, and one dog had a penetrating ulcer on the lesser curvature of the stomach as well as numerous superficial ulcers scattered throughout this organ and the first portion of the duodenum. Russell and Nasset (15) have studied the effects of various vitamin supplements and of whole yeast on the digestion and absorption of carbohydrates. A distinct stimulatory effect of fresh yeast on gastro-intestinal motility was noted. The increased motility was accompanied by increased rates of digestion and absorption of carbohydrate. Additional amounts of thiamine, riboflavin, nicotinic acid and pyridoxine had no effect, but these authors present evidence indicating that crystalline pantothenic acid is responsible for at least part of the yeast effect. Our results point to two factors, inositol and pantothenic acid. A deficiency of either factor produces the same picture, suggesting a similarity of action."

"Heublein and his coworkers(26) have recently described the syndrome in dogs associated with deficiency of the entire B complex. The radiological picture noted by these investigators is identical with that described herein. They, too, eliminated thiamine, riboflavin and nicotinic acid as factors of vital importance in the syndrome. As we demonstrate here, the syndrome observed is that of a pantothenic acid-inositol deficiency."

"The clinical aspects of this problem have received extensive consideration. Mackie (15) first noted in the small intestine changes of a functional nature, in non-tropical sprue. Subsequently similar changes were observed in chronic idiopathic steatorrhea (17), in ulcerative colitis (18) and in tropical sprue (19), as well as in a variety of conditions, nephrosis and diabetes insipidus (20), icterus (21), diseases of mesenteric lymphatics and intra-abdominal cancer, etc. Elsom et al (22), maintained patients on a diet deficient in the B complex and studied among other things the gastro-intestinal tract. They noted after one week on the diet a mild anorexia, which ultimately became extreme. Abdominal distension and constipation were marked. Mild soreness of the tongue was an occasional complaint. As the deficiency became more pronounced, nausea and vomiting were frequent, and during the last few days on the diet abdominal pain was noted. Appetite returned promptly following administration of thiamine. This return of appetite was not associated with any change in the other gastro-intestinal symptoms except that abdominal pain disappeared. Toward the end of the second week of thiamine therapy, appetite again decreased, and, in spite of continued administration of thiamine and addition to riboflavin, did not again return to normal until yeast was given."
@semi-god - let me know when you're convinced about the value of a natural extract because it seems that there are infinite cards.​

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Pantothenic Acid and the Gastrointestinal Tract | Nutrition Reviews | Oxford Academic

"Dogs made deficient in pantothenic acid frequently develop gastritis or enteritis and intussusception (Schaefer, McKibbin, and Elvehjem, J. Biol. Chem. 143, 321 (1942)). Hypoglycemia may also occur and may be severe enough to cause coma. While the low blood sugar values can be explained readily by the attendant severe hepatic degeneration and probable absence of liver glycogen, it is possible that poor absorption of carbohydrate is also partly responsible. There is need, therefore, for further elucidation of the function pantothenic acid plays in the physiology of the gastrointestinal tract. Valuable information of this type has been supplied by Bly, Heggeness, and Naeset (J. Nutrition 26, 161 (1943)).
These workers studied the effects of pantothenic acid and of inositol on the motility, digestion, and absorption in the upper intestinal tract of dogs."

"The emptying time was lengthened from the normal time of about six hours to between ten and twelve hours during pantothenic acid deficiency periods. Addition of 220 micrograms of calcium pantothenate per kilogram per day restored the motility to normal. The promptness with which this change occurred is not clear from the data provided, but in one comment the authors state that “the emptying time dropped to a normal average of 5.6 hours over a period of a month.” Since deficiency resulted with the experimental diet which provided daily approximately 130 micrograms of pantothenic acid per kilogram of body weight, and since an additional 220 micrograms per kilogram corrected the deficiency, the dog's requirement is probably between 130 and 350 micrograms per kilo per day. Furthermore, digestion and absorption of Carbohydrate and protein were 40 to 60 per cent less during the deficient than during the control periods. Pyridoxine administration was ineffective in altering the course of the deficiency. Inositol given subcutaneously (up to 33 mg. per day) had no effect, but when it was given orally in amounts as great as 500 mg. per day it temporarily increased motility but decreased digestion and absorption. Its effect, therefore, was more like that of a cathartic. The experiment was complicated by the fact that after five or six months a salt deficiency also appeared. At this time pantothenic acid was less effective in restoring and maintaining normal gastrointestinal function unless a salt supplement was also given."​

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Effect of pantothenic acid and pantethine on intestinal motility in aging rats
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THE EFFECT OF PANTOTHENIC ACID DEFICIENCY ON GASTRIC SECRETION AND MOTILITY (Only gastric)

 

[Amazoniac]

I have the impression that it doesn't normalize the function in a healthy way, but it seems to work therneveless:
Pantothenic acid alcohol in the treatment of chronic constipation in the aged.
Dexpanthenol (Ro 01-4709) in the treatment of constipation. - PubMed - NCBI

 

[Amazoniac]

Articles related to 5364199 - PubMed - NCBI
@Diokine - the results from a "pantothenic acid acetylcholine/cholinergic" search might interest you.

 

[Amazoniac]

The vitamins: chemistry, physiology, pathology

The vitamins: chemistry, physiology, pathology
The vitamins: chemistry, physiology, pathology #Zeus​

 

[Amazoniac]

I have the impression that it doesn't normalize the function in a healthy way, but it seems to work therneveless:
Pantothenic acid alcohol in the treatment of chronic constipation in the aged.
Dexpanthenol (Ro 01-4709) in the treatment of constipation. - PubMed - NCBI

Acetylcholine comes from acetyl CoA (pantothenic acid) and choline. As suspected at this point, a chronic insufficiency in any of them can be involved in constipation:
https://www.researchgate.net/profil...idiopathic-slow-transit-type-constipation.pdf

Role of presynaptic nicotinic acetylcholine receptors in the regulation of gastrointestinal motility. - PubMed - NCBI

Our emancipator wrote about this system and how problems arise when there's an excess of acetylcholine or not enough cholinesterase.
New Page Title Here

But the problem here is being managed by increasing acetylcholine.
A choline deficiency is a possibility despite a normal intake:
Supplementary Choline Raises Risk Of Blood Clots; Aspirin To The Rescue
Now that is a good reason to consider a topical supplement. #Zeus

Manganese involvement:
The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain
http://www.neurotoxicology.org.il/wp-content/uploads/2016/02/Mn_ACh_2007_NeuroToxicology.pdf

Caffeine:
Inhibition of acetylcholinesterase by caffeine, anabasine, methyl pyrrolidine and their derivatives - ScienceDirect
Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase

 

[Giraffe]

regarding rheumatoid arthritis:

"It is difficult to account for the high blood pantothenic acid level of vegetarians compared with those of people who consume a normal balanced diet. It is possible that the intestinal bacterial flora is different in the two groups, and that the bacterial flora of vegetarians contains actively pantothenic acid synthesising organisms."

"It seems clear from our findings that freedom from rheumatoid arthritis is correlated in some way with a blood pantothenic acid level of 0.95 -1.0 mcg. per ml. of whole blood, and that if the value falls below 0.95 mcg. per ml. symptoms of rheumatoid arthritis make their appearance. This view is confirmed by the fact that the lower the level of the pantothenic acid in the blood, the greater is the severity of the symptoms of rheumatoid arthritis. For example, it was found that patients with a blood pantothenic acid level of 40-50 mcg. per 100 ml. whole blood were in nearly every case badly crippled, and in two cases bedridden."

 

[Giraffe]

THE EFFECT OF PANTOTHENIC ACID DEFICIENCY ON GASTRIC SECRETION AND MOTILITY

SUMI'MARY AND CONCLUSIONS
1. Pantothenic acid deficiency was induced in a group of three normal human volunteers, by diet and the administratioln of a metabolic antagonist.
2. Two of three subjects developed severe depression of gastric secretion which returned to normal after the experiment had been terminated.
3. The changes affected the volume of parietal and non-parietal components secreted in response to a meal, to histamine and to insulin.
4. Pepsin secretion in response to insulin and histamine was also diminished but pepsin response to a meal was unaffected.
5. It is postulated that the parietal cells were depleted of an essential metabolic factor, possibly coenzyme A. The diminished secretion may, however, have been an indirect result of depression of function of the adrenal cortex.
6. There was no significant change in gastric motility as a result of pantothenic acid deficiency.

@Bananom