Is This The Ultimate DOPAMINE Restorative Drug? 9-Methyl-β-carboline (9-MBC)

[johnwester130]

Hey all,

I am yet to personally experiment with 9-Methyl-β-carboline (9-MBC), but after reading about it's potential applications and benefits, I decided to make a YouTube video to discuss it's somewhat remarkable features.

Here is the entire video:



Some mechanisms of action I will post here, which you can find more in the video above:
•Protein and gene expression of tyrosine hydroxylase, as well as gene expression of tyrosine hydroxylase-relevant transcription factors (Nurr1, Pitx3, CREB, CREBBP, GATA2 and GATA3), was increased after 9-MBC treatment (11).
• Up-regulates, differentiates and protects dopaminergic neurons, dendrites and synapses, especially in the substantia nigra of the midbrain and in the hippocampus (1)(2)(6)(7)
• Increases dopamine synthesis (1)(7).
• Increases neurotrophins/neurotrophic factors (NGF, BDNF, CDNF [6], GDNF, SHH (5) and decrease apoptic signals (like caspase-3) (2)
• Decreases inflammation, preventing microglia proliferation and chemokine release [4], protecting against lipopolysaccharide toxicity (5) and reducing LDH (2)(6) (lactate dehydrogenase). Reduces α-synuclein (4)(5), the aggregation of which form insoluble fibrils (like lewy bodies), one of the causes of some neurodegenerative disorders, like PD and AD (alzheimer's disease)
• Increases TH (6) (tyrosine hydroxylase) expression and its transcription factors, and interacts with tyrosine kinases, TH converts L-tyrosine to L-Dopa, needed for the synthesis of the catecholamines, especially dopamine
• MAO-B inhibition (3), preventing the formation of neurotoxic substances, like DOPAC (from the dopamine metabolization), 6-OH-DA (oxydopamine), and MPDP⁺/MPP⁺ (from MPTP), the major cause of dopaminergic neurons death.
• Increases/protects/recovers the NADH dehydrogenase (or "complex I" (6) which catalyzes the transfer of electrons between NADH and Co-Q10), enhancing the mithocondrial respiration chain (7)
• Increase ATP (6)
Even when 9-MBC was administered chronically, it exerted no neurotoxic effects (11).

cam tjos reduce prolactin?

 

[Lokzo]

cam tjos reduce prolactin?

Potentially.

 

[golder]

Doesn’t anything that increases dopamine, by definition, reduce prolactin to some degree?

 

[milkboi]

Doesn’t anything that increases dopamine, by definition, reduce prolactin to some degree?

For some reason, Amphetamine, which strongly increases Dopamine signaling, doesn't significantly decrease Prolactin. Nicotine too IIRC

 

[johnwester130]

do the capsules work? some say the liquid tastes too bad

 

[PeskyPeater]

You want the liquid used sublingual, as the oral 9MBC is metabolized into a toxin.
It tastes like very strong nasty licorice

 

[Chad_Catholic]

Any other testimonials?

 

[Ismail]

Hey all,

I am yet to personally experiment with 9-Methyl-β-carboline (9-MBC), but after reading about it's potential applications and benefits, I decided to make a YouTube video to discuss it's somewhat remarkable features.

Here is the entire video:



Some mechanisms of action I will post here, which you can find more in the video above:
•Protein and gene expression of tyrosine hydroxylase, as well as gene expression of tyrosine hydroxylase-relevant transcription factors (Nurr1, Pitx3, CREB, CREBBP, GATA2 and GATA3), was increased after 9-MBC treatment (11).
• Up-regulates, differentiates and protects dopaminergic neurons, dendrites and synapses, especially in the substantia nigra of the midbrain and in the hippocampus (1)(2)(6)(7)
• Increases dopamine synthesis (1)(7).
• Increases neurotrophins/neurotrophic factors (NGF, BDNF, CDNF [6], GDNF, SHH (5) and decrease apoptic signals (like caspase-3) (2)
• Decreases inflammation, preventing microglia proliferation and chemokine release [4], protecting against lipopolysaccharide toxicity (5) and reducing LDH (2)(6) (lactate dehydrogenase). Reduces α-synuclein (4)(5), the aggregation of which form insoluble fibrils (like lewy bodies), one of the causes of some neurodegenerative disorders, like PD and AD (alzheimer's disease)
• Increases TH (6) (tyrosine hydroxylase) expression and its transcription factors, and interacts with tyrosine kinases, TH converts L-tyrosine to L-Dopa, needed for the synthesis of the catecholamines, especially dopamine
• MAO-B inhibition (3), preventing the formation of neurotoxic substances, like DOPAC (from the dopamine metabolization), 6-OH-DA (oxydopamine), and MPDP⁺/MPP⁺ (from MPTP), the major cause of dopaminergic neurons death.
• Increases/protects/recovers the NADH dehydrogenase (or "complex I" (6) which catalyzes the transfer of electrons between NADH and Co-Q10), enhancing the mithocondrial respiration chain (7)
• Increase ATP (6)
Even when 9-MBC was administered chronically, it exerted no neurotoxic effects (11).

@Lokzo have you tried this yet bud?

 

[frankmp0]

Hey all,

Reviving this thread, I decided to try out this compound as I'm trying to improve my dopamine functioning. Although I have been able to reverse my ADHD, I believe I still have damage from years of extreme porn / video game usage.

Have you tried this yet Lucas? Anyone else? I got the bottle listed on your website. That's one thing I want to address, I would suggest you change the bottle to the powder, at least on the part that you recommend. The bottle contains PEG-400, which is a (almost certainly)highly estrogenic petrochemical.. I should've read the ingredients list on the site, but it was hard to find and I neglected to do it. My fault. A lot of people were reporting photosensitivity, but I can't see how that would have to do with the 9-MBC, I haven't noticed that as an effect with any other beta carboline substances, such as syrian rue.

I only used it for 2 days(10mg/1ml both times) before noticing it had Polyethylene Glycol and I stopped using. I might buy the powdered version, although I don't have any more crypto. I did notice an increase in dopamine and a decrease in "damage" from dopaminergics.

What I mean by this is that although I've been able to get rid of my ADHD symptoms, they come back quickly after too much social media or not meditating consistently. I feel like although I've been using social media, which I'm attempting to learn how to use right now, I DEFINITELY notice less "damage" and an increased ability to transition between activities. Feel a lot more dopaminergic basically.

I might try it again even though it has PEG. I'm not sure if PEG is high bioavailability orally, I'm pretty sure it doesn't but I discontinued just to be safe.

When opening the package, I accidentally scissored the dropper so I had to use my pine pollen dropper

I think more people should try this out and give responses back.

What do you guys think?