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Eugenol: Helps Reduce Loss Of Dopamine / Protects From Aluminum / Neuro-protective & Anti-stress

Grapelander

Member
Joined
Mar 26, 2019
Messages
1,296
Location
Sonoma County
Eugenol
Cloves Effect on Parkinson’s Disease – Animal Study
Eugenol
helped reduce the loss of Dopamine, DOPAC, and HVA that was caused by Parkinson's Disease (6-OHDA).
Eugenol protected the dopamine-using neurons in the brain by helping to stop the oxidation of lipids in the cell membranes which produce more free radicals. This in turn allows enzymes (Catalase & GPx) that break down free radicals and convert Hydrogen Peroxide back into Water to be more effective.

Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Eugenol holds potential as a neuroprotective agent through its hydrophobic, antioxidant, and anti-apoptotic properties, as well as its neurotrophic ability against Al-induced brain toxicity in rats.

Essential oil eugenol: sources, extraction techniques and nutraceutical perspectives
Molecular mechanisms of eugenol in various nutraceutical properties

Antioxidant activity
Inhibitory effect on lipid peroxidation
Inhibits ROS & RNS formations

Antimicrobial activity
Induces cell lysis in Gram positive & negative bacteria
Inhibition of IKK/NF-κB, ERK and p38MAPK signaling pathways

Anti-inflammatory potential
Prevents inflammatory cytokine expression
Inhibitory effect on prostaglandin synthesis
Suppresses COX-2 activity
Inactivates TNFα factors
Inhibits NF-kappaB pathways

Anti-cancer activity
Trigger cell apoptosis
Target E2E1/survivin pathways
Apoptosis in MCF-7 human breast cancer cells
Suppresses COX-2 gene in HT-29 human colon cells
Inhibits prostaglandin E2 production
Reduces DNA oxidation
Inhibits matrix metalloproteinase activity (MMP-9)
Inactivates ERK proteins/pathways

Neuro-protective & anti-stress related perspectives
Inhibits lipid peroxidation
Prevents reduction in dopamine contents
Inhibitory action on 5-lipoxygenase activity
Reduces NO, MDA and ROS concentrations
Augments glutathione contents in cortex and cerebellum regions
Attenuate acetylcholinesterase activity and cytosolic calcium content in brain regions
Regulated serotonergic system in amygdala region
Diminishes RS-induced rise in plasma corticosterone levels
Augmented changes in serotonin (5-HT) levels
Decreases level of norepinephrine in brain regions
Reduces ulcer index
Modulates HPA & BMS

Antidiabetic potential
Inhibits α-glucosidases activity
Inhibits formation of AGE
Prevents attachment of glucose to serum albumin
Upregulates the concentration of antioxidative enzymes

Hypocholesterolemic perspectives
Scavenges free radicals
Maintains antioxidant status of body
Reduces cellular oxidative damage
Increases the concentration of SOD enzymes
Decreases the levels of serum MDA
Inhibitory effect on HMG-CoA reductase
 

Vinny

Member
Joined
Dec 11, 2018
Messages
1,262
Age
50
Location
Paphos, Cyprus
Eugenol
Cloves Effect on Parkinson’s Disease – Animal Study
Eugenol
helped reduce the loss of Dopamine, DOPAC, and HVA that was caused by Parkinson's Disease (6-OHDA).
Eugenol protected the dopamine-using neurons in the brain by helping to stop the oxidation of lipids in the cell membranes which produce more free radicals. This in turn allows enzymes (Catalase & GPx) that break down free radicals and convert Hydrogen Peroxide back into Water to be more effective.

Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Eugenol holds potential as a neuroprotective agent through its hydrophobic, antioxidant, and anti-apoptotic properties, as well as its neurotrophic ability against Al-induced brain toxicity in rats.

Essential oil eugenol: sources, extraction techniques and nutraceutical perspectives
Molecular mechanisms of eugenol in various nutraceutical properties

Antioxidant activity
Inhibitory effect on lipid peroxidation
Inhibits ROS & RNS formations

Antimicrobial activity
Induces cell lysis in Gram positive & negative bacteria
Inhibition of IKK/NF-κB, ERK and p38MAPK signaling pathways

Anti-inflammatory potential
Prevents inflammatory cytokine expression
Inhibitory effect on prostaglandin synthesis
Suppresses COX-2 activity
Inactivates TNFα factors
Inhibits NF-kappaB pathways

Anti-cancer activity
Trigger cell apoptosis
Target E2E1/survivin pathways
Apoptosis in MCF-7 human breast cancer cells
Suppresses COX-2 gene in HT-29 human colon cells
Inhibits prostaglandin E2 production
Reduces DNA oxidation
Inhibits matrix metalloproteinase activity (MMP-9)
Inactivates ERK proteins/pathways

Neuro-protective & anti-stress related perspectives
Inhibits lipid peroxidation
Prevents reduction in dopamine contents
Inhibitory action on 5-lipoxygenase activity
Reduces NO, MDA and ROS concentrations
Augments glutathione contents in cortex and cerebellum regions
Attenuate acetylcholinesterase activity and cytosolic calcium content in brain regions
Regulated serotonergic system in amygdala region
Diminishes RS-induced rise in plasma corticosterone levels
Augmented changes in serotonin (5-HT) levels
Decreases level of norepinephrine in brain regions
Reduces ulcer index
Modulates HPA & BMS

Antidiabetic potential
Inhibits α-glucosidases activity
Inhibits formation of AGE
Prevents attachment of glucose to serum albumin
Upregulates the concentration of antioxidative enzymes

Hypocholesterolemic perspectives
Scavenges free radicals
Maintains antioxidant status of body
Reduces cellular oxidative damage
Increases the concentration of SOD enzymes
Decreases the levels of serum MDA
Inhibitory effect on HMG-CoA reductase
Thanks
What would be the effective dose to get all the benefits?
 

Grapelander

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Thread starter
Joined
Mar 26, 2019
Messages
1,296
Location
Sonoma County
Thanks
What would be the effective dose to get all the benefits?
My personal experience is with clove oil - which is 80-90% eugenol.
I use 1 to 2 drops on some baking soda to brush my teeth; or 1 to 2 drops in a cup of water as a rinse.
It is very powerful - careful if you have sensitive skin.
If I was going to eat it I would use 1 drop on some sugar or honey.
You can get a smaller amount in some herbs:
Cloves
Cinnamon
Nutmeg
Ocimum basilicum (Sweet basil)
Ocimum gratissimum (African basil)
Ocimum tenuiflorum (Tulsi or holy basil)
Star anise
Lemon balm
Bay
Thyme
 

Vinny

Member
Joined
Dec 11, 2018
Messages
1,262
Age
50
Location
Paphos, Cyprus
My personal experience is with clove oil - which is 80-90% eugenol.
I use 1 to 2 drops on some baking soda to brush my teeth; or 1 to 2 drops in a cup of water as a rinse.
It is very powerful - careful if you have sensitive skin.
If I was going to eat it I would use 1 drop on some sugar or honey.
You can get a smaller amount in some herbs:
Cloves
Cinnamon
Nutmeg
Ocimum basilicum (Sweet basil)
Ocimum gratissimum (African basil)
Ocimum tenuiflorum (Tulsi or holy basil)
Star anise
Lemon balm
Bay
Thyme
Thank you.
 

Mauritio

Member
Joined
Feb 26, 2018
Messages
4,501
My personal experience is with clove oil - which is 80-90% eugenol.
I use 1 to 2 drops on some baking soda to brush my teeth; or 1 to 2 drops in a cup of water as a rinse.
It is very powerful - careful if you have sensitive skin.
If I was going to eat it I would use 1 drop on some sugar or honey.
You can get a smaller amount in some herbs:
Cloves
Cinnamon
Nutmeg
Ocimum basilicum (Sweet basil)
Ocimum gratissimum (African basil)
Ocimum tenuiflorum (Tulsi or holy basil)
Star anise
Lemon balm
Bay
Thyme
Interesting eugenol seeks to tick all the boxes. What benefits did you experience from it ?
 

ilhanxx

Member
Joined
Feb 26, 2019
Messages
270
put 7 8 piece of clove in 1 liter water, wait for min 12 hour, drink everyday, after a meanwhile you will see your hair darker.
another tip, if you feel very tired in the day, put 3 4 clove in your tea, it will go away your tiredness, but you shouldn't try on energetic time, it hardly reduce your cortisol and you feel tired(opposite)
 

Grapelander

Member
Thread starter
Joined
Mar 26, 2019
Messages
1,296
Location
Sonoma County
Interesting eugenol seeks to tick all the boxes. What benefits did you experience from it ?
I brush my teeth with clove oil/baking soda every day - have not been to the dentists in years.
Use it in the humidifier to clean the air.
 

SOMO

Member
Joined
Mar 27, 2018
Messages
1,094
Eugenol is used in Dentistry as an anesthetic and as an ingredient in Filling/Composite material.

The Eugenol is Antimicrobial + reduces hypersensitivity and protects dental nerves from the Aluminum in fillings.
 

robertf

Member
Joined
Nov 10, 2014
Messages
65
I have preached cloves for over 20 years. Revised this past decade for appropriate doshas. Didn't know about the aluminum protection, thanks.
Don't forget its action on parasite ova.

Since they are so strong you only need a little bit and fry/cook in oil.
 

Sunrise

Member
Joined
Jun 7, 2018
Messages
59
Eugenol is used in Dentistry as an anesthetic and as an ingredient in Filling/Composite material.

The Eugenol is Antimicrobial + reduces hypersensitivity and protects dental nerves from the Aluminum in fillings.
I would love contact details of that dentista or detalles filling receipt to try ti reproduce It. Or Give It my dentist. Heard It can help regrow enamel
 

milkboi

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Joined
Sep 25, 2018
Messages
1,614
Location
Germany
What amount of Eugenol is a good dose to serve as protection against Dopamine metabolites?
 

Inaut

Member
Joined
Nov 29, 2017
Messages
3,295
What amount of Eugenol is a good dose to serve as protection against Dopamine metabolites?
Also wondering the same. Georgi mentioned something about this during DR podcast the other day.
 

Makrosky

Member
Joined
Oct 5, 2014
Messages
3,664
Has anybody tried it for intestinal disinfection?
I have used in the past adding it to the carrot salad. Basically some cloves finely grinded in the electric grinder, spiked over the carrot. It made it more powerful for sure. But didn't use it for too long because of the inconvenience of having to grind it, the taste, etc... Will have to give it a new try.
 

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