Eugenol: Helps Reduce Loss Of Dopamine / Protects From Aluminum / Neuro-protective & Anti-stress

Lewis Acid

Member
Joined
Mar 26, 2019
Messages
270
Eugenol
Cloves Effect on Parkinson’s Disease – Animal Study
Eugenol
helped reduce the loss of Dopamine, DOPAC, and HVA that was caused by Parkinson's Disease (6-OHDA).
Eugenol protected the dopamine-using neurons in the brain by helping to stop the oxidation of lipids in the cell membranes which produce more free radicals. This in turn allows enzymes (Catalase & GPx) that break down free radicals and convert Hydrogen Peroxide back into Water to be more effective.

Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Eugenol holds potential as a neuroprotective agent through its hydrophobic, antioxidant, and anti-apoptotic properties, as well as its neurotrophic ability against Al-induced brain toxicity in rats.

Essential oil eugenol: sources, extraction techniques and nutraceutical perspectives
Molecular mechanisms of eugenol in various nutraceutical properties

Antioxidant activity
Inhibitory effect on lipid peroxidation
Inhibits ROS & RNS formations

Antimicrobial activity
Induces cell lysis in Gram positive & negative bacteria
Inhibition of IKK/NF-κB, ERK and p38MAPK signaling pathways

Anti-inflammatory potential
Prevents inflammatory cytokine expression
Inhibitory effect on prostaglandin synthesis
Suppresses COX-2 activity
Inactivates TNFα factors
Inhibits NF-kappaB pathways

Anti-cancer activity
Trigger cell apoptosis
Target E2E1/survivin pathways
Apoptosis in MCF-7 human breast cancer cells
Suppresses COX-2 gene in HT-29 human colon cells
Inhibits prostaglandin E2 production
Reduces DNA oxidation
Inhibits matrix metalloproteinase activity (MMP-9)
Inactivates ERK proteins/pathways

Neuro-protective & anti-stress related perspectives
Inhibits lipid peroxidation
Prevents reduction in dopamine contents
Inhibitory action on 5-lipoxygenase activity
Reduces NO, MDA and ROS concentrations
Augments glutathione contents in cortex and cerebellum regions
Attenuate acetylcholinesterase activity and cytosolic calcium content in brain regions
Regulated serotonergic system in amygdala region
Diminishes RS-induced rise in plasma corticosterone levels
Augmented changes in serotonin (5-HT) levels
Decreases level of norepinephrine in brain regions
Reduces ulcer index
Modulates HPA & BMS

Antidiabetic potential
Inhibits α-glucosidases activity
Inhibits formation of AGE
Prevents attachment of glucose to serum albumin
Upregulates the concentration of antioxidative enzymes

Hypocholesterolemic perspectives
Scavenges free radicals
Maintains antioxidant status of body
Reduces cellular oxidative damage
Increases the concentration of SOD enzymes
Decreases the levels of serum MDA
Inhibitory effect on HMG-CoA reductase
 

Vinny

Member
Joined
Dec 11, 2018
Messages
1,175
Age
48
Location
Paphos, Cyprus
Eugenol
Cloves Effect on Parkinson’s Disease – Animal Study
Eugenol
helped reduce the loss of Dopamine, DOPAC, and HVA that was caused by Parkinson's Disease (6-OHDA).
Eugenol protected the dopamine-using neurons in the brain by helping to stop the oxidation of lipids in the cell membranes which produce more free radicals. This in turn allows enzymes (Catalase & GPx) that break down free radicals and convert Hydrogen Peroxide back into Water to be more effective.

Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Neuroprotective effects of eugenol against aluminum induced toxicity in the rat brain
Eugenol holds potential as a neuroprotective agent through its hydrophobic, antioxidant, and anti-apoptotic properties, as well as its neurotrophic ability against Al-induced brain toxicity in rats.

Essential oil eugenol: sources, extraction techniques and nutraceutical perspectives
Molecular mechanisms of eugenol in various nutraceutical properties

Antioxidant activity
Inhibitory effect on lipid peroxidation
Inhibits ROS & RNS formations

Antimicrobial activity
Induces cell lysis in Gram positive & negative bacteria
Inhibition of IKK/NF-κB, ERK and p38MAPK signaling pathways

Anti-inflammatory potential
Prevents inflammatory cytokine expression
Inhibitory effect on prostaglandin synthesis
Suppresses COX-2 activity
Inactivates TNFα factors
Inhibits NF-kappaB pathways

Anti-cancer activity
Trigger cell apoptosis
Target E2E1/survivin pathways
Apoptosis in MCF-7 human breast cancer cells
Suppresses COX-2 gene in HT-29 human colon cells
Inhibits prostaglandin E2 production
Reduces DNA oxidation
Inhibits matrix metalloproteinase activity (MMP-9)
Inactivates ERK proteins/pathways

Neuro-protective & anti-stress related perspectives
Inhibits lipid peroxidation
Prevents reduction in dopamine contents
Inhibitory action on 5-lipoxygenase activity
Reduces NO, MDA and ROS concentrations
Augments glutathione contents in cortex and cerebellum regions
Attenuate acetylcholinesterase activity and cytosolic calcium content in brain regions
Regulated serotonergic system in amygdala region
Diminishes RS-induced rise in plasma corticosterone levels
Augmented changes in serotonin (5-HT) levels
Decreases level of norepinephrine in brain regions
Reduces ulcer index
Modulates HPA & BMS

Antidiabetic potential
Inhibits α-glucosidases activity
Inhibits formation of AGE
Prevents attachment of glucose to serum albumin
Upregulates the concentration of antioxidative enzymes

Hypocholesterolemic perspectives
Scavenges free radicals
Maintains antioxidant status of body
Reduces cellular oxidative damage
Increases the concentration of SOD enzymes
Decreases the levels of serum MDA
Inhibitory effect on HMG-CoA reductase
Thanks
What would be the effective dose to get all the benefits?
 

Lewis Acid

Member
Thread starter
Joined
Mar 26, 2019
Messages
270
Thanks
What would be the effective dose to get all the benefits?
My personal experience is with clove oil - which is 80-90% eugenol.
I use 1 to 2 drops on some baking soda to brush my teeth; or 1 to 2 drops in a cup of water as a rinse.
It is very powerful - careful if you have sensitive skin.
If I was going to eat it I would use 1 drop on some sugar or honey.
You can get a smaller amount in some herbs:
Cloves
Cinnamon
Nutmeg
Ocimum basilicum (Sweet basil)
Ocimum gratissimum (African basil)
Ocimum tenuiflorum (Tulsi or holy basil)
Star anise
Lemon balm
Bay
Thyme
 

Vinny

Member
Joined
Dec 11, 2018
Messages
1,175
Age
48
Location
Paphos, Cyprus
My personal experience is with clove oil - which is 80-90% eugenol.
I use 1 to 2 drops on some baking soda to brush my teeth; or 1 to 2 drops in a cup of water as a rinse.
It is very powerful - careful if you have sensitive skin.
If I was going to eat it I would use 1 drop on some sugar or honey.
You can get a smaller amount in some herbs:
Cloves
Cinnamon
Nutmeg
Ocimum basilicum (Sweet basil)
Ocimum gratissimum (African basil)
Ocimum tenuiflorum (Tulsi or holy basil)
Star anise
Lemon balm
Bay
Thyme
Thank you.
 

Mauritio

Member
Joined
Feb 26, 2018
Messages
1,797
My personal experience is with clove oil - which is 80-90% eugenol.
I use 1 to 2 drops on some baking soda to brush my teeth; or 1 to 2 drops in a cup of water as a rinse.
It is very powerful - careful if you have sensitive skin.
If I was going to eat it I would use 1 drop on some sugar or honey.
You can get a smaller amount in some herbs:
Cloves
Cinnamon
Nutmeg
Ocimum basilicum (Sweet basil)
Ocimum gratissimum (African basil)
Ocimum tenuiflorum (Tulsi or holy basil)
Star anise
Lemon balm
Bay
Thyme
Interesting eugenol seeks to tick all the boxes. What benefits did you experience from it ?
 

ilhanxx

Member
Joined
Feb 26, 2019
Messages
215
put 7 8 piece of clove in 1 liter water, wait for min 12 hour, drink everyday, after a meanwhile you will see your hair darker.
another tip, if you feel very tired in the day, put 3 4 clove in your tea, it will go away your tiredness, but you shouldn't try on energetic time, it hardly reduce your cortisol and you feel tired(opposite)
 

Lewis Acid

Member
Thread starter
Joined
Mar 26, 2019
Messages
270
Interesting eugenol seeks to tick all the boxes. What benefits did you experience from it ?
I brush my teeth with clove oil/baking soda every day - have not been to the dentists in years.
Use it in the humidifier to clean the air.
 

SOMO

Member
Joined
Mar 27, 2018
Messages
853
Eugenol is used in Dentistry as an anesthetic and as an ingredient in Filling/Composite material.

The Eugenol is Antimicrobial + reduces hypersensitivity and protects dental nerves from the Aluminum in fillings.
 

robertf

Member
Joined
Nov 10, 2014
Messages
62
I have preached cloves for over 20 years. Revised this past decade for appropriate doshas. Didn't know about the aluminum protection, thanks.
Don't forget its action on parasite ova.

Since they are so strong you only need a little bit and fry/cook in oil.
 

Mauritio

Member
Joined
Feb 26, 2018
Messages
1,797
Thanks guys

It's also in many commercial toothpastes!

Has anybody tried it for intestinal disinfection?
 
Similar threads
Thread starter Title Forum Replies Date
md_a Clove Oil (eugenol) Inhibited 97.3% Lipid Peroxidation And Decreases TGF‐β1 Expression Scientific Studies 3
postman Eugenol Supplements 5
Mauritio Caprylic acid is anti-bacterial, lowers IL-8, helps Glioblastoma Fats 0
haidut Pregnenolone (P5) May Be Ergogenic And Helps Recovery From Exercise Scientific Studies 0
Hgreen56 Rinsing Beef Reduced Fat Content But With Extra Oil Helps "suck" The Extra Fat Out Of The Beef? Diet 0
ddjd Take B1 With Vitamin C - It Helps Block The Effects Of Thiaminase Ask For Help or Advice 3
Frankdee20 What Helps Turn High Cholesterol Into Hormones Ask For Help or Advice 44
zarrin77 High Potassium Helps To Increase Muscle Mass Compared To Low Potassium Diet In Mice Scientific Studies 7
D Raw Wildflower Honey Helps Me Sleep Blood Sugar 1
ecstatichamster Bag Breathing Helps Flu; Ventilators And Oxygen Probably Kill Ray Peat Topics 73
md_a Vitamin C Helps Covid-19 Infected Patients By Regulating Iron? Scientific Studies 5
F Mucuna Pruriens Helps So Much Supplements 10
P Vitamin E + Sildenafil (Viagra) Helps ED? Male Issues 6
J Potassium Channel Activty Helps Hair Loss? Hair & Nails 5
J Inducing Mild Fever Helps Depression Scientific Studies 2
BTD Flaky Skin For Years; Prednisone Is The Only Thing That Helps! Skin 14
jzeno Niacin Helps Me To Fall Asleep. Similar Effect For Anyone Else? Experiments 7
ecstatichamster Ability To Grind Teeth Helps Deal With Stress Science 14
ddjd T3 Causing Insomnia. Cortisol (Prednisone) Helps Me Get To Sleep. What's Going On? Ask For Help or Advice 39
Frankdee20 What Helps Reduce Smoking ? Ask For Help or Advice 57
C Vitamin D Helps Supplemental Thyroid Work Supplements, Pharmaceutical Drugs 3
M What Helps Kidneys To Filter Better? Ask For Help or Advice 50
M Does Anyone Know If Matcha Green Tea Helps To Lower Serotonin? Cortisol, Serotonin, Histamine 0
T Renal Tubular Acidosis - What Helps? Ask For Help or Advice 2
M What Helps To Lower CVD ? Good Social Links Miscellaneous 2
SB4 DHEA + Pregnenolone Helps POTS But Kills Libido? Thyroid and Hormones 25
A An Anti-inflammatory Helps Prevent Heart Disease. And It's Only $200k Per Year! Ask For Help or Advice 3
Arnold Grape Vitamin C Helps To Reduce Iron C 18
biggirlkisss Coffee Helps My Digustion Why? Ask For Help or Advice 26
L Another Aspirin Helps Cancer Study Scientific Studies 2
A Milk And Sugar Helps My Anxiety But Also Causes Digestive Problems Mental Issues 11
haidut Progesterone Protects From Flu And Helps Recovery From SARS / ARDS Scientific Studies 2
SarahBeara Chromium Is The Only Thing That Helps, Alternative? Minerals 49
G High tech virtual reality program helps people understand schizophrenia Breaking News 0
Y RP Says Glucose Helps T4 To T3, Then Why Fructose? Diet, Recipes 112
burtlancast Coffee Helps Prevent Type 2 Diabetes Scientific Studies 1
J Coconut Oil Helps Absorb Vitamin E Topically Articles & Scientific Studies 1
N New member hopes Peatarian lifestyle helps CFS Meet & Greet 5
bzmazu How to Reduce the Pain of Life...Choose Health Health 0
L How To Reduce Damage From Mandatory Covid-19 Vaccination? Toxins, Detoxification 71
MaxVerstappen Microdosing Mushrooms To Reduce Serotonin Autism 36
R How To Reduce Stress? Cortisol, Serotonin, Histamine 1
C How Does Colloidal Silver Reduce Levothyroxine Absorption? Ask For Help or Advice 2
J How To Reduce The Constipation Effect From Calcium Supplements Calcium 5
S Methods To Reduce Allergic Reaction From Foods?/diet Advice Ask For Help or Advice 15
Lokzo Riboflavin And Pyridoxine Restore Dopamine Levels And Reduce Oxidative Stress In Brain Of Rats Scientific Studies 0
haidut Vitamin K May Help Reduce Arterial Stiffness & Improve Blood Pressure Scientific Studies 9
bluefish General Inflammation. (how To Reduce) Ask For Help or Advice 17
GutFeeling Proviron May Reduce DHEA Conversion To Testosterone Scientific Studies 1
jase_11six Any Alternative Ways To Reduce Prostaglandin D2 Instead Of Aspirin? Aspirin 2

Similar threads

Top