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Insulin Signaling In Osteoblasts Integrates Bone Remodeling And Energy Metabolism

paymanz

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http://www.cell.com/abstract/S0092-8674%2810%2900621-5

Highlights

▸ Insulin signaling in mouse osteoblasts increases activity of the hormone osteocalcin ▸ Osteocalcin activation depends on the acidic pH in the bone resorption area ▸ Enhanced osteocalcin activity promotes glucose metabolism via bone resorption ▸ Regulation of glucose metabolism by bone also occurs in humans

Summary

The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity. To achieve this function insulin signaling in osteoblasts takes advantage of the regulation of osteoclastic bone resorption exerted by osteoblasts. Indeed, since bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin. Accordingly, increasing or decreasing insulin signaling in osteoblasts promotes or hampers glucose metabolism in a bone resorption-dependent manner in mice and humans. Hence, in a feed-forward loop, insulin signals in osteoblasts activate a hormone, osteocalcin, that promotes glucose metabolism.
 

paymanz

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and osteocalcin is a vitamin K dependent protein.and also has relation to co2
 

tara

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Interesting. Link or reference?
Did you get from it what specific pH (acidic) is referred to here:
paymanz said:
... bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin.
whether that is inter-(I think?) or intra-cellular pH?
 

paymanz

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tara said:
Interesting. Link or reference?
Did you get from it what specific pH (acidic) is referred to here:
paymanz said:
... bone resorption occurs at a pH acidic enough to decarboxylate proteins, osteoclasts determine the carboxylation status and function of osteocalcin.
whether that is inter-(I think?) or intra-cellular pH?
sorry i forgot link.edited it
i didnt read full text yet maybe it says if it intra or inter cellular.thats interesting for me to know too.
 
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