osteocalcin

  1. forterpride

    Test for K2 deficiency

    Hello all. Was hoping for some guidance. My father takes statins and I read that they can deplete K2, which he supplements with because he has high calcium score/arterial calcification. My fear is that the statins are negating the K2 he is taking. But he won’t stop the statins since his...
  2. haidut

    Statins May Cause Insulin Resistance By Depleting Vitamin K

    A great study, which both highlights the dangers of statins while also providing a plausible mechanism for those side effects that both FDA and Big Pharma vehemently continue to dispute. This plausible mechanism involves the inhibition of vitamin K2 (MK-4) synthesis, which requires the same...
  3. A

    Osteocalcin, Not Adrenaline, Drives Fight Or Flight Response

    article of september 2019: Bone, not adrenaline, drives fight or flight response When faced with a predator or sudden danger, the heart rate goes up, breathing becomes more rapid, and fuel in the form of glucose is pumped throughout the body to prepare an animal to fight or flee. These...
  4. haidut

    Pregnenolone Is Anabolic For Bones

    So much for pregnenolone being an inactive steroid. The study below shows that even very low concentrations of pregnenolone are high anabolic for the bone and its effects are comparable to those of potent steroids like DHT or the well-known androgenic-anabolic steroid (AAS) commonly known as...
  5. P

    Effect Of Lidocaine On Bone Matrix Formation By Osteoblasts

    Effect of lidocaine on bone matrix formation by osteoblasts Effect of lidocaine on bone matrix formation by osteoblasts Srinivas Pentyala*, Emily Hughes, Pooja Mysore, Supriya Mishra, Julie Miller, Aleef Rahman and Kyle Urbanczyk Correspondence: Srinivas Pentyala...
  6. P

    Statins May Exert Beneficial Effects Through A Pathway Other Than It's Cholesterol Lowering Action

    Was surprised when saw a study showing statins have positive effects on bones, did a bit of searching and it turned out that it has some positive action,generally, through inhibiting rho kinase, which also is protective against heart disease. Im not promoting statin use at all(for obvious...
  7. A

    Vitamin K Reduces Belly Fat In Some Groups

    This research comes from a commercial spin-off of Maastricht University in the Nederlands. Authors in this group seem interested in vascular calcification. Here, the interest was in osteoblast-specific protein osteocalcin (OC)and metabolsim.. They chose to use a not-huge dose on MK-7 rather than...
  8. P

    Bone Regulates Glucose Metabolism As An Endocrine Organ Through Osteocalcin

    Bone Regulates Glucose Metabolism as an Endocrine Organ through Osteocalcin. - PubMed - NCBI Skeleton was considered as a dynamic connective tissue, which was essential for mobility, calcium homeostasis, and hematopoietic niche. However more and more evidences indicate that skeleton works not...
  9. haidut

    Vitamin K And D Reverse Muscle Aging, May Act Like Sports Doping Agents

    Vitamin D and K have a primary role in bone metabolism, together with calcium and the androgenic hormones. Ray has written about the importance of these vitamins not only for bone health but also for insulin sensitivity and accelerating deactivation of estrogen. Many of these beneficial effects...
  10. P

    Bone As A Regulator Of Glucose Metabolism

    http://www.ncbi.nlm.nih.gov/pubmed/24127499 For a long time the only functions attributed to the skeleton were locomotion and calcium storage. Over the last decade, this view has changed. Genetic studies in mice have shown that bone metabolism is regulated by the autonomic nervous system and...
  11. P

    Manganese Supplementation Improves Mineral Density Of The Spine And Femur And Serum Osteocalcin In R

    Manganese supplementation improves mineral density of the spine and femur and serum osteocalcin in rats. - PubMed - NCBI The effect of manganese (Mn) supplementation on bone mineral density (BMD) and bone metabolism parameters was determined in ovariectomized Sprague-Dawley rats. Rats were...
  12. P

    Insulin Signaling In Osteoblasts Integrates Bone Remodeling And Energy Metabolism

    http://www.cell.com/abstract/S0092-8674%2810%2900621-5 Highlights ▸ Insulin signaling in mouse osteoblasts increases activity of the hormone osteocalcin ▸ Osteocalcin activation depends on the acidic pH in the bone resorption area ▸ Enhanced osteocalcin activity promotes glucose metabolism...
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