• Due to excessive bot signups along with nefarious actors we are limiting forum registration. Keep checking back for the register link to appear. Please do not send emails or have someone post to the forum asking for a signup link. Until the current climate changes we do not see a change of this policy. To join the forum you must have a compelling reason. Letting us know what skills/knowledge you will bring to the community along with the intent of your stay here will help in getting you approved.

Statins May Cause Insulin Resistance By Depleting Vitamin K


Mar 18, 2013
USA / Europe
A great study, which both highlights the dangers of statins while also providing a plausible mechanism for those side effects that both FDA and Big Pharma vehemently continue to dispute. This plausible mechanism involves the inhibition of vitamin K2 (MK-4) synthesis, which requires the same enzymes that synthesize cholesterol. As the authors themselves state, vitamin K is crucial for proper glucose metabolism. One of the key roles of vitamin K is as a co-factor for the synthesis of osteocalcin and it is the latter that is a powerful regulator of both insulin as well as gonadal steroid synthesis, both of which heavily influence glucose homeostasis. Perhaps studies like this will finally convince the FDA to get off of its high horse and admit that vitamin K is not just some puny vitamin used clinically by "an obscure Asian country" but rather a powerful regulator of systemic health.

Statin use is associated with insulin resistance in participants of the Canadian Multicentre Osteoporosis Study
Statin use may lead to ‘unintended consequence’ of insulin resistance

"...A cohort of Canadian adults prescribed statins, and hydrophilic statins, in particular, had higher levels of insulin resistance compared with non-statin users, according to findings published in the Journal of the Endocrine Society. “There is emerging data to suggest that by inhibiting the production of intermediates of cholesterol biosynthesis, statins also inhibit the mevalonate pathway and impede the production of vitamin K2 in peripheral tissues,” Rachel M. Holden, MD, a nephrologist and associate professor in the department of medicine at Queen’s University in Kingston, Ontario, Canada, and colleagues wrote in the study background. There is growing evidence to suggest that vitamin K2 plays a key role in glucose homeostasis as well as vascular calcification. On this background, we hypothesized that statin use would be associated with both insulin resistance and vascular calcification in community-dwelling participants of a large longitudinal study of osteoporosis.”

"...“Statins, widely prescribed drugs to lower cholesterol, may have unintended consequences related to glucose homeostasis that could be relevant in healthy aging,” the researchers wrote. “In those individuals with risk factors for diabetes, consideration for choosing non-lipophilic statins and avoidance of rosuvastatin and lipophilic statins may provide the intended cardiovascular protection without the increased incidence of insulin resistance.”


Jun 26, 2017
spacedoc.com (Dr. Duane Graveline - formerly doctor to the astronauts, deceased) has a lot of articles on the subject of blockage of the mevalonate pathway.
Similar threads
Thread starter Title Forum Replies Date
P Statins May Exert Beneficial Effects Through A Pathway Other Than It's Cholesterol Lowering Action Articles & Scientific Studies 6
forterpride Is this drug healthier than statins? Ask For Help or Advice 12
Mito 20-Year Follow-up Of Statins In Children With Familial Hypercholesterolemia Articles & Scientific Studies 0
haidut Statins More Than Double The Risk Of Diabetes Compared To Non-users Scientific Studies 0
haidut PUFA/Statins Promote UV Damage & Skin Cancer (melanoma), Cholesterol Is Protective Scientific Studies 4
Hugh Johnson "Hypercholesterolaemia Caused By Glyphosate Is Now Treated By Statins" Health 3
D Statins And Bone Growth Cholesterol 0
haidut Lowering Cholesterol Increases CVD Deaths, Benefits Of Statins Exaggerated Scientific Studies 12
charlie Statins: Heart Disease Drug Speeds Up Ageing Process, Warns New Research Articles 6
haidut Aspirin Better Than Statins For Cholesterol And Triglycerides Scientific Studies 16
haidut Safety And Efficacy Of Statins Deliberately Exaggerated Articles 4
charlie Parkinson's Link To Statins: Calls To End Widespread Use Of The Drug Miscellaneous Health Discussions 2
charlie Statins Stimulate Atherosclerosis And Heart Failure: Pharmacological Mechanisms Scientific Studies 17
haidut Statins cause fat buildup, adrenergic activation causes muscle wasting Scientific Studies 0
J KMUD: PUFA, Heart Health, Statins KMUD Radio-The Herb Doctors 4
G Cholesterol is Protective (Statins, Thyroid, Metabolic Rate, Kmud Interview: Oct.10, 2010 - Sugar II [Clipped.I 0
aliml The Anti Depression Pills that may Kill Cancer Cancer 1
aliml Niclosamide may be a therapeutic candidate for ALS Articles & Scientific Studies 1
Jam "Vaccines containing micro-organisms which can be excreted by the vaccinated person and taken up by others, may be employed" Vaccines 7
haidut Fascism has arrived - unvaxxed Austrians may be jailed Vaccines 521
SOMO Dying of AIDS and Cancer - not joking. Proton Therapy ($2500) may be my last hope. Anyone able to donate? Ask For Help or Advice 62
aliml Elevating the level of hypoxia inducible factor may be a new potential target for the treatment of depression Scientific Studies 0
haidut Endotoxin (LPS) may directly cause cancerization of normal cells Scientific Studies 2
haidut Uncoupling metabolism/OXPHOS may treat inflammatory conditions Scientific Studies 4
haidut Serotonin, SSRI drugs may be the cause of IBD, Parkinson's, diabetes, etc. Scientific Studies 31
GorillaHead Doxycycline may cure skin cancer but also can age your skin and give you hairloss. Here is how. Supplements, Pharmaceutical Drugs 1
haidut Vitamin B1 and/or biotin may treat Huntington Disease (HD) Scientific Studies 35
H Circumcision may increase STI rates Scientific Studies 5
haidut Vitamin A may treat anosmia (loss of smell) due to COVID-19 Scientific Studies 8
GorillaHead Vaccines may not be required anymore in the future. Pills are coming. Thoughts? Supplements, Pharmaceutical Drugs 20
haidut PUFA required for periodontal disease, aspirin may help Scientific Studies 12
ecstatichamster Yes, Nick Minaj may be right: swollen balls are entirely possible after the "vaccine" Vaccines 24
ImprovingDaily Almost fully recovered from Covid pneumonia, here are some tips for anyone who may need them. Viruses, Parasites, Fungus, Vaccines 20
Apollo Is lactose free milk safe ? (galactose may be toxic) Dairy 25
haidut Having SARS-CoV-2 confers MUCH stronger immunity than vaccines, and it may last a lifetime Scientific Studies 33
haidut Vitamin D, reducing fat oxidation may treat lung fibrosis, COVID-19 Scientific Studies 19
haidut How lipolysis may damage organs such as the heart Scientific Studies 0
OccamzRazer Income idea for anyone who's lost or may lose their job Miscellaneous 77
A Https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250771/ Mortality From Coronavirus Disease 2019 Increases With Unsaturated Fat and May Be Reduced by Metabolism 1
J Think I may have vitamin D toxicity Skin 15
RenaissanceMan Omega-3 EPA and DHA may be the solution to "male pattern baldness" / hair loss in men Polyunsaturated Fats, Seed Oils 29
G CDC may be preparing internment camps Ask For Help or Advice 54
G The COVID Vaccine May Induce COVID Sensitivity Vaccines 0
D New article frames SIBO as a gender specific disease; anabolic steroids may be useful treatment Articles & Scientific Studies 3
haidut COVID-19 vaccines may cause 82%+ miscarriage rate Scientific Studies 85
haidut Iron supplementation may not cure anemia, unless nutrition is also improved Scientific Studies 1
haidut Damaged mitochondria may cause 90%+ of Parkinson Disease (PD) cases Scientific Studies 4
haidut Aging is an energy deficiency problem, taking cardiolipin may reverse it Scientific Studies 8
haidut It's official: COVID-19 vaccination may be stemming evolution of “fitter” SARS-CoV-2 variants Scientific Studies 15
A How teen marijuana use may alter the shape of the brain Scientific Studies 0

Similar threads