Statins May Cause Insulin Resistance By Depleting Vitamin K

haidut

Member
Forum Supporter
Joined
Mar 18, 2013
Messages
19,798
Location
USA / Europe
A great study, which both highlights the dangers of statins while also providing a plausible mechanism for those side effects that both FDA and Big Pharma vehemently continue to dispute. This plausible mechanism involves the inhibition of vitamin K2 (MK-4) synthesis, which requires the same enzymes that synthesize cholesterol. As the authors themselves state, vitamin K is crucial for proper glucose metabolism. One of the key roles of vitamin K is as a co-factor for the synthesis of osteocalcin and it is the latter that is a powerful regulator of both insulin as well as gonadal steroid synthesis, both of which heavily influence glucose homeostasis. Perhaps studies like this will finally convince the FDA to get off of its high horse and admit that vitamin K is not just some puny vitamin used clinically by "an obscure Asian country" but rather a powerful regulator of systemic health.

Statin use is associated with insulin resistance in participants of the Canadian Multicentre Osteoporosis Study
Statin use may lead to ‘unintended consequence’ of insulin resistance

"...A cohort of Canadian adults prescribed statins, and hydrophilic statins, in particular, had higher levels of insulin resistance compared with non-statin users, according to findings published in the Journal of the Endocrine Society. “There is emerging data to suggest that by inhibiting the production of intermediates of cholesterol biosynthesis, statins also inhibit the mevalonate pathway and impede the production of vitamin K2 in peripheral tissues,” Rachel M. Holden, MD, a nephrologist and associate professor in the department of medicine at Queen’s University in Kingston, Ontario, Canada, and colleagues wrote in the study background. There is growing evidence to suggest that vitamin K2 plays a key role in glucose homeostasis as well as vascular calcification. On this background, we hypothesized that statin use would be associated with both insulin resistance and vascular calcification in community-dwelling participants of a large longitudinal study of osteoporosis.”

"...“Statins, widely prescribed drugs to lower cholesterol, may have unintended consequences related to glucose homeostasis that could be relevant in healthy aging,” the researchers wrote. “In those individuals with risk factors for diabetes, consideration for choosing non-lipophilic statins and avoidance of rosuvastatin and lipophilic statins may provide the intended cardiovascular protection without the increased incidence of insulin resistance.”
 

JudiBlueHen

Member
Forum Supporter
Joined
Jun 26, 2017
Messages
482
spacedoc.com (Dr. Duane Graveline - formerly doctor to the astronauts, deceased) has a lot of articles on the subject of blockage of the mevalonate pathway.
 
P

Peatness

Guest
A hit piece on anyone who has experienced adverse event from statins. Notice that the telegraph article does not link the actual study article


The article in the trusted Lancet. The study was partly funded by big pharma, of course it was.

 

JudiBlueHen

Member
Forum Supporter
Joined
Jun 26, 2017
Messages
482
A hit piece on anyone who has experienced adverse event from statins. Notice that the telegraph article does not link the actual study article


The article in the trusted Lancet. The study was partly funded by big pharma, of course it was.

Basic summary: your muscle aches are the result of anything EXCEPT statins. Probably just because you are old and worn out.
 
OP
haidut

haidut

Member
Forum Supporter
Joined
Mar 18, 2013
Messages
19,798
Location
USA / Europe
If statins increase StAR and thereby risk for diabetes should we be careful about other substances that increase StAR??


View: https://twitter.com/SilkeLeFay/status/1415523496617119746?t=_P_xrGIwCW5xPA0aSo2ntw&s=19


The increased StAR from statins is probably an adaptive response to their ability to lower cholesterol - i.e. the cell senses a cholesterol "deficiency" and increases StAR expression to keep cholesterol flow into the mitochondria at desired levels. Still, chronic statin use has been shown to lead to functional hypogonadism and this is probably the main mechanism through which statins cause diabetes, corroborated by the fact that androgen therapy in males and DHEA therapy in both sexes can prevent/reverse diabetes, usually by leading to weight (fat) loss and thus decreased total estrogenic load as well as by direct opposition of these steroids to cortisol (a proven diabetogen). Since vitamin D - a known anti-obesity and anti-diabetic agent - is also derived from cholesterol, statin use would likely result in vitamin D deficiency too, as well as the vitamin K drop mentioned by the original article in the thread.
 

cremes

Member
Joined
Oct 29, 2022
Messages
304
Location
Chicago
Statin use antagonizes vitamin D and K? Based on a recent thread about D, K and **** size, seems like statin use will shrink your ****.

Autocorrect capitalized every usage of ****. I’ll allow it.
 
Joined
Mar 10, 2021
Messages
21,494
Studies show that the use of statin drugs can raise your blood sugar, which may increase the risk of diabetes, especially among those who have other risk factors for diabetes or are taking higher doses of statins.

However, the risk is usually less than other risk factors for developing diabetes, like obesity.”

 

Similar threads

Back
Top Bottom