Statins May Cause Insulin Resistance By Depleting Vitamin K


Mar 18, 2013
USA / Europe
A great study, which both highlights the dangers of statins while also providing a plausible mechanism for those side effects that both FDA and Big Pharma vehemently continue to dispute. This plausible mechanism involves the inhibition of vitamin K2 (MK-4) synthesis, which requires the same enzymes that synthesize cholesterol. As the authors themselves state, vitamin K is crucial for proper glucose metabolism. One of the key roles of vitamin K is as a co-factor for the synthesis of osteocalcin and it is the latter that is a powerful regulator of both insulin as well as gonadal steroid synthesis, both of which heavily influence glucose homeostasis. Perhaps studies like this will finally convince the FDA to get off of its high horse and admit that vitamin K is not just some puny vitamin used clinically by "an obscure Asian country" but rather a powerful regulator of systemic health.

Statin use is associated with insulin resistance in participants of the Canadian Multicentre Osteoporosis Study
Statin use may lead to ‘unintended consequence’ of insulin resistance

"...A cohort of Canadian adults prescribed statins, and hydrophilic statins, in particular, had higher levels of insulin resistance compared with non-statin users, according to findings published in the Journal of the Endocrine Society. “There is emerging data to suggest that by inhibiting the production of intermediates of cholesterol biosynthesis, statins also inhibit the mevalonate pathway and impede the production of vitamin K2 in peripheral tissues,” Rachel M. Holden, MD, a nephrologist and associate professor in the department of medicine at Queen’s University in Kingston, Ontario, Canada, and colleagues wrote in the study background. There is growing evidence to suggest that vitamin K2 plays a key role in glucose homeostasis as well as vascular calcification. On this background, we hypothesized that statin use would be associated with both insulin resistance and vascular calcification in community-dwelling participants of a large longitudinal study of osteoporosis.”

"...“Statins, widely prescribed drugs to lower cholesterol, may have unintended consequences related to glucose homeostasis that could be relevant in healthy aging,” the researchers wrote. “In those individuals with risk factors for diabetes, consideration for choosing non-lipophilic statins and avoidance of rosuvastatin and lipophilic statins may provide the intended cardiovascular protection without the increased incidence of insulin resistance.”


Jun 26, 2017
259 (Dr. Duane Graveline - formerly doctor to the astronauts, deceased) has a lot of articles on the subject of blockage of the mevalonate pathway.
Similar threads
Thread starter Title Forum Replies Date
P Statins May Exert Beneficial Effects Through A Pathway Other Than It's Cholesterol Lowering Action Articles & Scientific Studies 6
Mito 20-Year Follow-up Of Statins In Children With Familial Hypercholesterolemia Articles & Scientific Studies 0
haidut Statins More Than Double The Risk Of Diabetes Compared To Non-users Scientific Studies 0
haidut PUFA/Statins Promote UV Damage & Skin Cancer (melanoma), Cholesterol Is Protective Scientific Studies 4
Hugh Johnson "Hypercholesterolaemia Caused By Glyphosate Is Now Treated By Statins" Health 3
D Statins And Bone Growth Cholesterol 0
haidut Lowering Cholesterol Increases CVD Deaths, Benefits Of Statins Exaggerated Scientific Studies 12
charlie Statins: Heart Disease Drug Speeds Up Ageing Process, Warns New Research Articles 4
haidut Aspirin Better Than Statins For Cholesterol And Triglycerides Scientific Studies 16
haidut Safety And Efficacy Of Statins Deliberately Exaggerated Articles 4
charlie Parkinson's Link To Statins: Calls To End Widespread Use Of The Drug Miscellaneous Health Discussions 2
charlie Statins Stimulate Atherosclerosis And Heart Failure: Pharmacological Mechanisms Scientific Studies 17
haidut Statins cause fat buildup, adrenergic activation causes muscle wasting Scientific Studies 0
J KMUD: PUFA, Heart Health, Statins KMUD Radio-The Herb Doctors 4
G Cholesterol is Protective (Statins, Thyroid, Metabolic Rate, Kmud Interview: Oct.10, 2010 - Sugar II [Clipped.I 0
Diokine LLLT may treat or prevent COVID-19 induced endothelial dysfunction Red Light, Infrared, LLLT 0
R May need higher dose of glycine (10g)? Amino Acids 0
R BCAAs, commonly taken for muscle growth, may decrease muscle growth! Scientific Studies 5
Jam Mortality From Coronavirus Disease 2019 Increases With Unsaturated Fat and May Be Reduced by Early Calcium and Albumin Supplementation Miscellaneous Health Discussions 3
yerrag Just Learned From Experience Bicarbonate Intake Isn't the Real Solution, May Even Cause Problems Supplements, Pharmaceutical Drugs 20
md_a COVID-19 spike proteins may cause neurological issues Scientific Studies 1
H What can be consumed that may mitigate mRNA vaccines from working? Vaccines 13
bzmazu Is COVID19 a New Type of Bio-Energetic Disease State? We May Find Out the Hard Way March 2021. Viruses, Parasites, Fungus, Vaccines 6
haidut Niacinamide may treat ALS by improving energetic state Scientific Studies 0
haidut Niacinamide may treat depression by improving energetic state Scientific Studies 8
haidut Sexual activity and stress levels (HPA activity) may determine longevity Scientific Studies 12
haidut Fasting ups estrogen & cortisol, decimates vitamin D, may cause diabetes Scientific Studies 11
haidut Serotonin may cause schizophrenia, Parkinson, and Alzheimer diseases Scientific Studies 2
haidut Low energy production (glucose metabolism) may cause andropause Scientific Studies 0
Lokzo Elevated Serum Estradiol Levels May Impair Erectile Function Scientific Studies 2
Mito Covid-19 Vaccines May Have Potentially Unpleasant Side Effects Miscellaneous Health Discussions 27
haidut People Who Refuse The COVID-19 Vaccine May Be Banned Socially Articles & Scientific Studies 158
haidut Estrogen May Be The Cause Of "estrogen-negative" Breast Cancer Scientific Studies 0
haidut Intermittent Fasting (IF) Ineffective And May Even Be Dangerous Scientific Studies 0
haidut Blocking Cortisol May Treat Even Terminal Cancers Scientific Studies 9
F CDC Weekly Updates - Comorbidities (May 28, 2020) Scientific Studies 0
Quelsatron Sweden May Make Preschool Obligatory From The Age Of Two Breaking News 0
Tarmander DARPA Says EMF May Be Causing A Trend Of Military Aircraft Accidents Articles & Newsletters 9
haidut Aromatase Inhibitor (AI) + DHT Combo May Reverse Kidney Disease (CKD) Scientific Studies 2
haidut Activation Of The Endotoxin Receptor (TLR4) May Cause Hearing Loss Scientific Studies 9
haidut The Case For Water Fluoridation May Be Nothing But A Corporate Plot Scientific Studies 9
haidut Parkinson Disease (PD) May Begin In The Gut Scientific Studies 0
haidut The Social Fabric In Western Countries May Be Unraveling Scientific Studies 126
haidut Simply Inhaling Endotoxin (LPS) May Cause Parkinson Disease (PD) Scientific Studies 2
S Weight Gain May Not Be A Bad Thing Weight 78
R Dandelion Root May Be Androgenic (Studies) Thyroid and Hormones 9
haidut Low Metabolism, Cellular Debris May Cause Huntington Disease (HD) Scientific Studies 0
haidut Doxycycline Akin To Meldonium / Mildronate, May Cure Triple-negative Breast Cancer Scientific Studies 0
haidut Pregnenolone (P5) May Be Ergogenic And Helps Recovery From Exercise Scientific Studies 0
Drareg Sedation To Manage 'lockdown Distress' May Have Led To Dementia Deaths Viruses, Parasites, Fungus, Vaccines 0

Similar threads