"We did load curves of glucose in four children on admission to hospital for cough, mild cervical adenopathy or low-grade fever. At the entrance the curve was diabetic and, after antibiotic treatment, at discharge it was normal. We happened to give 30 grams of sugar to a 4-year-old boy who had a fever for a few hours. The 30 grams caused an incredible increase in circulating sugar, up to 240 g / dl, a value that is found only in diabetics."
So does insulin resistance and diabetes 2 is caused by infection?
Anyway this study show that inflammation impair insulin production and insulin sensibility:
www.hindawi.com
"During the incubation of the infectious disease there is often a phase of viraemia. The virus circulates longer and in greater quantities if the ability to pick up antigens residing in the liver is reduced. The greater the attachment to the internal organs becomes. The virus can attach itself to the facial nerve, or neurons in the brain, or beta cells in the pancreas, or endothelium, or simply to a muscle in the neck or ligament under strain, depending on its affinity. A fortnight later, a massive lymphocyte response eliminates the virus everywhere. The disease will no longer be called influenza but will be called autoimmune, and respectively: facial paralysis, encephalitis, diabetes, Schoenlein Henoch, stiff neck, arthritis or periarthritis, or tendonitis."
So Autoimmune disease is created from virus, bacteria or yeasts os other parasites and the inflammatory phases is only immunopathology as Marshall site report:
https://mpkb.org/home/mp/immunopathology
https://mpkb.org/home/protocol/immunopathology
https://mpkb.org/home/mp/managing_immunopathology
So AIP diet avoid the microbes in the gut to overgrow freeing immunity to fight but if the caloric intake isn't fixed it doesn't work to increase the immune system skills to fight pathogens, I suppose that translating the whole book in English can be very illuminating as we say in Italy.
I want to fisnish this post with another couple of parts of the book:
"In most subjects, physical activity is low and affects total metabolic consumption by no more than one third of basic metabolism or RMR (Danforth. 1983). In people: ul sedentary activity is no more than 15-20% of the RMR. This is due to the use of heaters, indoor living, abundant clothing, and even machines instead of legs and arms. Even today it is easy to do a physical activity for an hour with an expenditure equal to five times the basal one, for example. walking uphill. In 24 hours, however, it is reached by only 4/24, that is, only one sixth of RMR.
In food diaries, caloric intake ranged from 600 to 1500 Cal per day in well-behaved adults. Daily physical activity could actually reach much higher values."
"The person who had the highest introduction was a 28-year-old young man, essentially norniale (celiac on a gluten-free diet for over 6 months) He did three hours a day of heavy athletics. he produced 4000 calories a day. By correcting his habits and improving his insulin sensitivity, he dropped to 2000-1500 Cal per day. His allctic performance is improved at the same time. Another young man ate 3500 Cal per day and after learning to have a higher sensitivity to insulin and progressively dropped.
After three or four years he was reporting in his diary an ìintroduct.io1le of 800 Cal per day. This young man was also celiac on a gluten-free diet. The improvement in insulin sensitivity had made him disappear from a generalized itch. The excessive decrease in introduction was related to a conduct that had become completely sedentary."
"We reluctantly give suggestions on how much a person should eat. People are used to very different consumption` the days are not the same, consumption changes. Alimentary canal and insulin sensitivity track metabolic consumption within four hours in our studies. Additional factors can always intervene, and you need to adjust to circumstances. To give an approximate idea of the needs we can say that with 600-1500 Cal per day almost everyone is fine. In our swampy, muggy region of Florence 1500 Cal taken by internal induction are sufficient even for a bit of heavy physical activity, and in the open air, in winter!"
And I finish with this part:
"We observed excellent growth in a young man who in one day did 4 hours of heavy sport and took 1900 Cal. Intake of more than two thousand calories per day therefore raises the suspicion that they are associated with insulin resistance."
I repeat the source: Amazon product ASIN 8846408624View: https://www.amazon.it/tavola-gioia-Capire-lalimentazione-bambino/dp/8846408624
And this was Mario Ciampolini: https://www.linkedin.com/in/mario-ciampolini-5368ab26
If we look for there are lots of very low caloric intake study we can find:
www.sciencedirect.com
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234895/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607294/
I suppose that in the first study 5:2 diet has best result because the two days of almost fasting reduce insulin and overgrow in the small intestine, because NAFLD isn't caused by fructose but by small intestinal overgrow of microbes, that's the true and the boor report this.
So only control the dynamic balance between two meal someone can reduce the insulin resistance.
And glucose is very important, a glucose deficiency can lead a lot of problems:
No glucose = no mucus = microbic attack on the surface of mucosa.
The same with insulin resistance with the problem that glucose can't be used well by immune system but help very well microbes.
So does insulin resistance and diabetes 2 is caused by infection?
Anyway this study show that inflammation impair insulin production and insulin sensibility:
Mechanisms Linking Inflammation to Insulin Resistance
Obesity is now widespread around the world. Obesity-associated chronic low-grade inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a major risk factor for insulin resistance and related diseases such as type 2 diabetes mellitus and metabolic syndromes. The...
"During the incubation of the infectious disease there is often a phase of viraemia. The virus circulates longer and in greater quantities if the ability to pick up antigens residing in the liver is reduced. The greater the attachment to the internal organs becomes. The virus can attach itself to the facial nerve, or neurons in the brain, or beta cells in the pancreas, or endothelium, or simply to a muscle in the neck or ligament under strain, depending on its affinity. A fortnight later, a massive lymphocyte response eliminates the virus everywhere. The disease will no longer be called influenza but will be called autoimmune, and respectively: facial paralysis, encephalitis, diabetes, Schoenlein Henoch, stiff neck, arthritis or periarthritis, or tendonitis."
So Autoimmune disease is created from virus, bacteria or yeasts os other parasites and the inflammatory phases is only immunopathology as Marshall site report:
https://mpkb.org/home/mp/immunopathology
https://mpkb.org/home/protocol/immunopathology
https://mpkb.org/home/mp/managing_immunopathology
So AIP diet avoid the microbes in the gut to overgrow freeing immunity to fight but if the caloric intake isn't fixed it doesn't work to increase the immune system skills to fight pathogens, I suppose that translating the whole book in English can be very illuminating as we say in Italy.
I want to fisnish this post with another couple of parts of the book:
"In most subjects, physical activity is low and affects total metabolic consumption by no more than one third of basic metabolism or RMR (Danforth. 1983). In people: ul sedentary activity is no more than 15-20% of the RMR. This is due to the use of heaters, indoor living, abundant clothing, and even machines instead of legs and arms. Even today it is easy to do a physical activity for an hour with an expenditure equal to five times the basal one, for example. walking uphill. In 24 hours, however, it is reached by only 4/24, that is, only one sixth of RMR.
In food diaries, caloric intake ranged from 600 to 1500 Cal per day in well-behaved adults. Daily physical activity could actually reach much higher values."
"The person who had the highest introduction was a 28-year-old young man, essentially norniale (celiac on a gluten-free diet for over 6 months) He did three hours a day of heavy athletics. he produced 4000 calories a day. By correcting his habits and improving his insulin sensitivity, he dropped to 2000-1500 Cal per day. His allctic performance is improved at the same time. Another young man ate 3500 Cal per day and after learning to have a higher sensitivity to insulin and progressively dropped.
After three or four years he was reporting in his diary an ìintroduct.io1le of 800 Cal per day. This young man was also celiac on a gluten-free diet. The improvement in insulin sensitivity had made him disappear from a generalized itch. The excessive decrease in introduction was related to a conduct that had become completely sedentary."
"We reluctantly give suggestions on how much a person should eat. People are used to very different consumption` the days are not the same, consumption changes. Alimentary canal and insulin sensitivity track metabolic consumption within four hours in our studies. Additional factors can always intervene, and you need to adjust to circumstances. To give an approximate idea of the needs we can say that with 600-1500 Cal per day almost everyone is fine. In our swampy, muggy region of Florence 1500 Cal taken by internal induction are sufficient even for a bit of heavy physical activity, and in the open air, in winter!"
And I finish with this part:
"We observed excellent growth in a young man who in one day did 4 hours of heavy sport and took 1900 Cal. Intake of more than two thousand calories per day therefore raises the suspicion that they are associated with insulin resistance."
I repeat the source: Amazon product ASIN 8846408624View: https://www.amazon.it/tavola-gioia-Capire-lalimentazione-bambino/dp/8846408624
And this was Mario Ciampolini: https://www.linkedin.com/in/mario-ciampolini-5368ab26
If we look for there are lots of very low caloric intake study we can find:
Treatment of NAFLD with intermittent calorie restriction or low-carb high-fat diet – a randomised controlled trial
The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction. Several diets have been proposed, with various effects spe…
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234895/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5607294/
I suppose that in the first study 5:2 diet has best result because the two days of almost fasting reduce insulin and overgrow in the small intestine, because NAFLD isn't caused by fructose but by small intestinal overgrow of microbes, that's the true and the boor report this.
So only control the dynamic balance between two meal someone can reduce the insulin resistance.
And glucose is very important, a glucose deficiency can lead a lot of problems:
No glucose = no mucus = microbic attack on the surface of mucosa.
The same with insulin resistance with the problem that glucose can't be used well by immune system but help very well microbes.
