Elevated free fatty acid cause insulin resistance


Mar 18, 2013
USA / Europe
More evidence for the Peat camp that it is elevated free fatty acids (FFA), not sugar, that causes insulin resistance. This study actually looked at niacin, since it is known to induce insulin resistance. The study confirmed that the freely circulating fatty acids (but not fat levels in muscle) is what leads to insulin resistance and diabetes. What this implies is that one can be obese and still have good insulin sensitivity, as long as the plasma fatty acid level is kept low.
Btw, niacin raises FFA while niacinamide suppresses it. No wonder Peat is not a fan of niacin, especially considering that it also increases histamine.


"...Insulin resistance is associated with increased circulating lipids and skeletal muscle lipid content. Chronic nicotinic acid (NA) treatment reduces insulin sensitivity and provides a model of insulin resistance. We hypothesized that the reduction in insulin sensitivity occurs via elevation of circulating nonesterified fatty acids (NEFAs) and an increase in intramyocellular lipid (IMCL). A total of 15 nondiabetic males (mean age 27.4 +/- 1.6 years) were treated with NA (500 mg daily for 1 week, 1 g daily for 1 week). Insulin sensitivity (glucose infusion rate [GIR]) was determined pre- and post-NA by euglycemic-hyperinsulinemic clamp. Substrate oxidation was determined by indirect calorimetry. Skeletal muscle lipid was assessed by estimation of long-chain acyl-CoA (LCACoA) and triglyceride (TG) content and by (1)H-magnetic resonance spectroscopy quantification of IMCL (n = 11). NA reduced GIR (P =.03) and nonoxidative glucose disposal (P <.01) and increased fasting NEFAs (P =.01). The decrease in GIR related significantly to the increase in fasting NEFAs (r(2) =.30, P =.03). The intrasubject increase in basal and clamp fat oxidation correlated with the decrease in GIR (r(2) =.45, P <.01 and r(2) =.63, P <.01). There were no significant changes in muscle LCACoA, TG, or IMCL content. Therefore, induction of insulin resistance by NA occurs with increased availability of circulating fatty acids to muscle rather than with increased muscle lipid content."
Similar threads
Thread starter Title Forum Replies Date
J Elevated 17 alpha hydroxyprogesterone low testosterone and male pattern baldness Blood Work, Labs 2
P Chronically elevated TSH but normal FT3 and FT4, despite Peating for years - ideas? Blood Work, Labs 13
F Can you trigger autoimmune response(elevated antibodies) from over medicating thyroid meds? Ask For Help or Advice 10
J High triglycerides, high cholesterol (LDL), mildly elevated AST Blood Work, Labs 5
johnwester130 Anti-Peat 7α-Hydroxy-DHEA elevated in alzeimer's, not DHEA Debate - Anti-Peat 3
Mito Serotonin is elevated in COVID- 19-associated diarrhoea Miscellaneous Health Discussions 39
Lokzo Elevated Serum Estradiol Levels May Impair Erectile Function Scientific Studies 2
koreus Just Got My Liver Enzymes Checked And They Are Elevated Blood Work, Labs 19
S HELP! Elevated Blood Labs Blood Work, Labs 5
C Elevated Progesterone? Ask For Help or Advice 16
M The Varicocele: Elevated Serotonin And Infertility (1980) Scientific Studies 9
M What Elevated Serotonin Actually Feels Like Mental Issues 42
md_a Both, Female And Male COVID-19 Patients May Present Elevated Estradiol Levels Articles & Scientific Studies 0
H Elevated Levels Of Thiamine(B1) And B6 Without Supplementation Cause? Blood Work, Labs 6
H Tanked Androgens, Elevated Thyroid, And Fat Gain Blood Work, Labs 14
poilochio Why Would A 17 Year Old Female Have Elevated Testosterone Blood Work, Labs 3
theDao Combating Elevated Cortisol & Histamine Resulting From Jogging & Sprinting Cortisol, Serotonin, Histamine 55
Infarouge Can Elevated Progesterone Aggrevate Or Cause Varicose Veins? Progesterone 12
haidut Elevated ESR And HCG Levels Are Strong Predictors Of Impending Cancer Diagnosis Scientific Studies 8
meatbag Suicides Have Elevated Serotonin, 5-HIAA, And Lower Serotonin Turnover Scientific Studies 2
debored13 What Does Elevated Bilirubin Indicate ? Ask For Help or Advice 2
haidut Elevated Maternal Estrogen (estradiol) Again Linked To Autism Scientific Studies 5
haidut Elevated Serotonin Increases Criminal Activity Scientific Studies 58
Lokzo DHT Is Elevated Following Sprint Exercise In Healthy Young Men Scientific Studies 1
jase_11six How To Clear Elevated RT3 When T3 Is High Health 14
fazlook Always Have Elevated FSH 23 :( Hormones 0
haidut Elevated PUFA In Blood Drive Metabolic Syndrome And Diabetes Scientific Studies 41
T Lower Prostate Cancer Risk In Men With Elevated Plasma Lycopene Levels Cancer 0
S Elevated Liver Enzymes Blood Work, Labs 6
x-ray peat Inclined Bed Therapy - Sleeping With The Head End Of The Bed Elevated Mind, Sleep, Stress 583
Nathan777 Elevated Homocysteine Ask For Help or Advice 9
haidut Cancer Is A State Of Chronic Stress With Elevated Lipolysis And Ketogenesis Scientific Studies 58
T List Of Things That CAUSE Elevated Estrogen? Ask For Help or Advice 14
B Is This Elevated Afternoon Cortisol? Suggestions? Cortisol, Serotonin, Histamine 5
Zpol Elevated Homocysteine And Phosphates, Low RBC Blood Work, Labs 8
I Elevated Liver Enzymes, Gene Mutation And Hypothyroid Blood Work, Labs 11
S Elevated Morning Blood Sugar Blood Sugar 18
S Feeling Better With Elevated Blood Sugar Blood Sugar 4
allblues Elevated Vit B12, Liver Enzymes Blood Work, Labs 10
Elchapchapchapo Newest Blood Test Results - Elevated Insulin / Insulin Resistance Blood Work, Labs 15
Bodhi Yellow Eyes, Elevated Bilirubin Aka Gilbert's Syndrome Ask For Help or Advice 26
Ahanu Elevated Light Levels In Classrooms Have A Significant Effect On Myopia Light 2
P Is glycine effective against elevated blood pressure? Scientific Studies 0
Y Sugar Molecule Links Red Meat Consumption And Elevated Cancer Risk In Mice Cancer 1
haidut Insulin Resistance Is Caused By Elevated Fatty Acids (FFA) Scientific Studies 51
haidut The "Flu" May Be Simply A Sign/Symptom Of Elevated Endotoxin Mind, Sleep, Stress 23
I Anyone taking Levothyroxine with normal TSH but low Free T4 and Free T3? Ask For Help or Advice 4
Pina Needle free Vaccines Vaccines 1
Bodrum Orange juice...WHY PULP FREE ??? Diet 12
Apollo Is lactose free milk safe ? (galactose may be toxic) Dairy 20

Similar threads