High T3 May Induce Insulin Resistance And High Blood Sugar

ddjd

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"The T3-only protocol and/or high doses of desiccated thyroid can cause high blood sugar, which causes A1C to rise to levels that warrant treatment. Thyroid levels, both too high or too low, have a direct impact on blood glucose. High doses of T3 have induced severe insulin resistance and type 2 diabetes in some patients, who are now on drugs like Metformin to control the condition.

High T3 levels stimulate the liver to produce excess glucose and the pancreas to produce excess insulin. This causes high blood glucose and insulin resistance. [8]

A comparison between the T3/rT3 ratios of insulin resistant and insulin sensitive subjects found a significantly higher T3/rT3 ratio in insulin resistant subjects. [9] Since a high ratio is actually the goal of the T3-only protocol, the protocol itself may induce insulin resistance as a side effect in some people.

A suppressed TSH is also expected on the T3-only protocol or on desiccated thyroid, but a low TSH has been shown to correlate to insulin resistance, higher insulin levels, and lower insulin sensitivity. This positive correlation holds even when Free T4 and T3 are within the reference range. In short, as T3 rises, so does insulin resistance. [10]"
 

Kartoffel

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It would be nice, if we could see the references behind those numbers...
 

jitsmonkey

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This notion is completely false
this is a function of being underfueled and adrenaline being high
So either
a) the dose is WAY too high and you can't fuel the dose and you're creating stress and thus increasing adrenaline production
or
b) the dose is fine and you're just not eating enough and you're creating stress and thus increasing adrenaline production

context always matters
T3 does not cause those things.
The stress of too much T3 relative to ability to fuel the amount does.

The symptoms listed are identical to any other high adrenaline high stress scenario.
 
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jitsmonkey

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It would be nice, if we could see the references behind those numbers...

this is the study
The association of insulin resistance with subclinical thyrotoxicosis. - PubMed - NCBI

the study doesn't control for ANYTHING other than the drugs and single meal administered
this is nonsense. I wonder what happens if we give metabolically dysfunctional people
living the avg dysfunctional life, eating the avg amount of PUFA significant amounts
of powerful metabolic stimulants? Yeah... exactly... bad ***t happens.

I actually took a couple of minutes to read the blog post using this reference
High Blood Sugar & Insulin Resistance Correlate with High T3
this person is simply using this position to justify why you should consult THEM
to handle your thyroid dosage. Its a careful narrative with cherry picked studies
to make the blog post point and box the reader in up against the rest of the blog narrative
which is pro-thyroid supplementation. Its just careful marketing to an ignorant audience.

Bottom line.... metabolic stimulants without fuel is bad news.
High stress/Adrenaline is bad news
Nothing new to see here
 
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Dr. B

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High T3, and generally hyperthyroidism, is also associated with much higher estrogen levels: Thyroid - hormone effects on steroid - hormone metabolism.

With studies like these, I can't see how it is safe to use T3, Dessicated thyroid, T4, etc.

Maybe @haidut has some comments
I’m not sure it would apply to true dessicated thyroid ? Were they using an unaltered thyroid glandular… i heard the thyroid gland used in these studies and by the medical industry is armoir thyroid which is a standardized dessicated thyroid. It has T3 and T4 but has calcitonin removed for sure, and probably also had the other things like T1, T2, parathyroid etc filtered out too?
 

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