High-dose thiamine supplementation improves glucose tolerance in hyperglycemic individuals: a randomized, double-blind cross-over trial - PubMed
Supplementation with high-dose thiamine may prevent deterioration in fasting glucose and insulin, and improve glucose tolerance in patients with hyperglycemia. High-dose thiamine supplementation may prevent or slow the progression of hyperglycemia toward diabetes mellitus in individuals with...
pubmed.ncbi.nlm.nih.gov
If thiamine is involved in glicolysis so in the use of glucose can a deficiency let accumulating glucose in the cells and creating hyperglycemia and then hyperinsulin.
Now if thymine block beat-oxidation too, it's possible that that create a major imbalance even in fatty metabolism:
Thiamine deficiency affects glucose transport and β‐oxidation in rats
Thiamine is recognized as a cofactor for many enzymes involved in intermediary metabolism responsible for energy production. Animal model of thiamine deficiency (TD) included direct evaluation of glucose uptake by estimation of [3] H‐deoxyglucose ...
www.ncbi.nlm.nih.gov
So can thiamine be a co-cause of diabetes?
If isn't glucose used by excess of lactate the cell can become extreme insulin resistant?
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