Thanks for the precision @ebs . I’ve read the same contradictions about HIGH LH, however low LH isn’t desirable. Although the body adapts to a lot of variance but my gut feeling is there’s a hypothyroidism/hypopituitary interrelationship here
You have 2 steps
- sTAR transfers the cholesterol from the outer to the inner membrane o the mitochondria. LH mediated
- P450scc (side chain cleavage) well... cleaves cholestérol in the mitochondria
A study in rats I’d need to find again showed that sodium lowers P450scc activity whereas potassium boosts it. But the rate limiter is the transfer, not the cleavage - can’t cleave what’s not transferred
I thought the rate limiter for pregnenolone from cholesterol was p450 or STAR mitochondrially?
You have 2 steps
- sTAR transfers the cholesterol from the outer to the inner membrane o the mitochondria. LH mediated
- P450scc (side chain cleavage) well... cleaves cholestérol in the mitochondria
A study in rats I’d need to find again showed that sodium lowers P450scc activity whereas potassium boosts it. But the rate limiter is the transfer, not the cleavage - can’t cleave what’s not transferred