Just saw this then. Pretty interesting stuff
First hint that body’s ‘biological age’ can be reversed
First hint that body’s ‘biological age’ can be reversed
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Thanks that's beautiful man
Scientists like this are why I read this ***t
https://www.gwern.net/docs/longevity/2019-fahy.pdf
[I'm about to read it lol]
[Maybe a little later...]
Sugar funnels into my 2L bottle... like the sands of time.
The approach with high dose DHEA and Metformin seems risky if all that’s „needed“ is increased HGH but offsetting of its insulin-resistance needs to be achieved simultaneously.
Maybe the compiled knowledge of the RPF could come up with a better stack. Note that thymus-degeneration seems to go hand in hand with androgen-homeostasis. This life extension comes at a price
There is no known mechanism whereby HGH is expected to affect the methylation profile. This is not to say that it does not do so, but it is just as viable to think that the combination of vitamin D and Zn is affecting methylation age.
High blood levels of vitamin D and zinc are known to be correlated with lower all-cause mortality and longer life expectancy. Metformin is being investigated in its own right as an anti-aging drug. DHEA has been promoted as an anti-aging supplement for decades, though existing studies indicate DHEA does not increase lifespan in mice. The principal effect of HGH is to increase the hormone IGF1, and DHEA also does this, far more cheaply and over-the-counter, but to a much smaller extent.
HGH is both expensive and theoretically suspect for long-term use. Elevated levels of IGF1 are known to decrease lifespan in rodents; dwarf mice and dwarf humans without IGF1 receptors live longer, healthier lives [ref]. Readers looking to make immediate changes to their personal stack based on the results of this experiment might try the four cheap and proven ingredients, leaving out the HGH for now.
Yep, however it is turned or interpreted, i would never touch that combo of Dhea 50mg, Metformin and HGH. If that’s the combined wisdom of prolific life-extenders than let them have fun.
- At the start of the test, the average epigenetic age of the group was already well below average chronological age. This is presumably because the subjects tended to be highly-motivated anti-aging enthusiasts. Whatever they were doing before the TRIIM study was already working well. By the Levine Clock, they were 17 years (!) younger than their chronological age, and by the GrimAge clock they were 2 years younger.
Sylvester Stallone used and still uses a ***t load of GH and he's doing pretty good
owning and starring in movie franchises worth hundreds of millions of dollars, in your 70s. yeah terrible performance. he probably looks better than you do nowFake hair, unatural looking teeth, make up.
The approach with high dose DHEA and Metformin seems risky if all that’s „needed“ is increased HGH but offsetting of its insulin-resistance needs to be achieved simultaneously.
Maybe the compiled knowledge of the RPF could come up with a better stack. Note that thymus-degeneration seems to go hand in hand with androgen-homeostasis. This life extension comes at a price
You could be right about enhanced conversion into estrogen/estrone depending on circumstances, haidut, but GH is a nighttime healing hormone. It replaces cortisol and permits the liver methylation cycle. It works together with thyroid and DHEA. In my opinion he is wrong about that hormone insofar as we evolved an importance for it in the circadian rhythm. He sees nighttime as a stressor to be counteracted in every way and in his mind nighttime food restriction should be abolished for our ultimate benefit - which someday might be the optimal solution - but that is unrealistic for our current knowledge - he is really thinking what we could do with the knowledge we'd have 25-100 years from now or something. He does not have the knowledge to do that successfully for people. i.e. Jaminet for some of his errors was more level-headed about this part of biology and GH fits into his ideas. Not trying to be a **** for no reason, I have been falling into this line of thinking about GH for some time - food at nighttime always ends up poorly for me - so personally I will be looking for this hormone at some point in my life (since I have been so sick I don't expect to outlive Peat or anything so maybe the scope of some of his ideas just doesn't apply to me). Anyway I didn't finish reading it (one helluva night) but I've been waiting for studies on GH + DHEA combined so this made me giddy like a schoolgirl. Metformin is kind of interesting because I wouldn't have thought to throw that in, so I dunno about that one, though one or two enzymes come to mind The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism...
(I'm willing to bet my life on it, so whenever I get there I'll let you know how it goes )
Yeah I still have to get that, thanks for that one. I forgot lol@Terma.
As can GH. Taking Gaba plain and simple before sleep for example.
GABA - An Effective Sleep Aid W/ GH Boosting Effects that Works Within 30 Minutes - Only 100 mg Pre-Bed Will Suffice - SuppVersity: Nutrition and Exercise Science for Everyone