Long term DHEA supplementation doubles androgens and progesterone in males

[Mauritio]

That's a pretty tiny sample size. What are the known negative effects of coming off DHEA? Does it reduce production of DHEA itself? What about FSH?

Sci-Hub, homie.

It doesn't work anymore.

 

[Vajra]

It doesn't work anymore.

I just used sci-hub.st and it worked. Try using the different domains.

 

[863127]

It doesn't work anymore.

libgen - MetaGer

Then on the Libgen front page, select "Search in: Scientific articles".

 

[Mauritio]

I just used sci-hub.st and it worked. Try using the different domains.

libgen - MetaGer

Then on the Libgen front page, select "Search in: Scientific articles".

Thanks guys , I'll try that!

 

[Mauritio]

I just used sci-hub.st and it worked. Try using the different domains.

Sci-hub.st still doenst work for me.
I'll try a VPN.

libgen - MetaGer

Then on the Libgen front page, select "Search in: Scientific articles".

It finds the article ,but still only sends le to the abstract and have to pay for full access.

 

[Mauritio]

I'll try a VPN.

Interestingly that worked . I switched my location to USA west coast and it worked. Maybe they have some kind of a ban in germany /europe because of the current lawsuit against sci hub.

 

[Mauritio]

Pretty sure I read the same study a while back. The males were already on TRT if I remember correctly.

So now I can safely say the men were not an TRT . They were on no medication 6 months prior .
I think you were referring to the women ,of which the majority were on HRT .

"Volunteers were recruited by advertisement. Nineteen subjects,aged 50–65, entered into the study; ten menopausal women (mean 54.
5 6 1.2 years) and nine men (mean 55.
6 6 1.9 years).
All subjects were non-obese, non-smokers with a body mass index (BMI) of 20–28 kg/m2 (mean, 23.2 6 0.7 kg/m2 forwomen; 26.2 6 0.6 kg/m2 for men). They were on no medications for at least 6 months before the study and had stable dietary and exercise regimens. Current medical illness was
excluded by history, physical examination, blood chemistryprofile (including renal, liver and thyroid function tests),
urinalysis and complete blood count. All subjects had normal baseline Beck Depression Inventory (Lyness et al., 1995).
Three subjects (2 women and 1 man) withdrew for personal reasons during the placebo phase of the study, prior to receiving
DHEA. Of the remaining eight postmenopausal women, seven
women were taking a daily oestrogen or oestrogen/progestagen
as hormone replacement therapy (HRT) and one woman was on no hormonal therapy. The protocol was approved by the Committee on Investigations Involving Human Subjects of the University of California-San Diego and all subjects gave oral and written informed consent."

 

[sunny]

Already posted, and I think more than once.

25mg Dhea Amazing Study In Men 2004

Hi all This is what believes me to think that low dose dhea is way better than higher dose. In the study where they gave men 50mg and 100mg the hormone profile wasnt raised at all apart from dhea and dheas. But just look at this study i dug up that uses 25mg only and how it raised the WHOLE...

raypeatforum.com

Also, here is why one would not want to take more than 15mg DHEA daily.

Why DHEA Must Be Taken In Small Doses Only

Once again, I am amazed at how well Ray's recommendations are backed by science. He has said that taking DHEA is fine and can restore proper youthful hormone balance. However, he cautioned that DHEA should only be taken in doses of no more than 10mg at once and preferably no more than 15mg...

raypeatforum.com

As far as using pregnenolone only - it may work.

Oral pregnenolone as hormone replacement therapy (HRT) in humans

As many of my readers know, the first step in steroid synthesis is the so-called "side-chain cleavage", which converts cholesterol into pregnenolone (P5). That step is known as the rate-limiting step in the steroid cascade, and its function depends on the redox status and ATP levels. In other...

raypeatforum.com

That being said, adding just 5mg DHEA to the larger pregnenolone does drastically increases its effects and the conversion downstream.
@Highserotonin90

 

[Kvothe]

I'm not sure if this study has been posted before , at least I haven found anything under the "DHEA" tag.
Anyways, it's always good to have more in vivo evidence for peaty substances and what they do in real life.

This study gave aging men with partial androgen deficiency (58-69)the "low dose" of 25mg DHEA for one year.

First of all the scores for tiredness , depression amd joint pain were less then half of what they were before the DHEA treatment.
So they also subjectively felt a difference .
View attachment 24594


The hormonal values are also very interesting:
DHEA : tripled
DHEA-S : quadrupled
TESTOSTERONE (total): almost doubled
TESTOSTERONE FREE: more than doubled
DHT: doubled
PROG: doubled
ALLOPREGNANOLONE: almost doubled
ANDROSTENEDIONE: almost doubled
17ohP : doubled
SHBG : slightly decreased
E1: doubled
E2 : more than doubled
LH+FSH: slightly decreased
CORTISOL :stayed the same
GH: more than doubled
View attachment 24596View attachment 24597View attachment 24598


It increases all beneficial hormones across the board , so I'm not surprised the men also subjectively felt a lot better .
The increase in estrogen is worrisome, although estrogen antagonists like progesterone, dht and allopregnanolone also increased just as much , so the rise in estrogen isn't unopposed.
To some degree the increase in E Will be because of increased T (aromatization) ,but I suspect the biggest part is from the large dosage . Since DHEA is known to be converted into estrogen in dosages above 5mg . So I'd suspect less estrogen and similar androgen increase if they kept the dosage lower .

Also noteworthy is the gradual increase in steroids. From months 0-6 there was a gradual increase in those hormones ,from 6-12 the increase was very little .
So if someone does an experiment with it , it might be worth to wait 6 months until you get a blood test , to see DHEAs full effects .

Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency - PubMed

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) age-related withdrawal is very likely to be involved in the aging process and the onset of age-related diseases, giving rise to the question of whether preventing or compensating the decline of these steroids may have...

pubmed.ncbi.nlm.nih.gov

I think this study should make you somewhat concerned about using so much DHEA. Total testosterone only saw a quantum leap after several months while free testosterone increased rapidly with a simultaneous decline in SHBG. Combined with the increase in estrogen and growth hormone, this doesn't look very favorable to me. An increase of free testosterone, estrogen, and progesterone while SHBG decreases points to liver issues.