1. 10% Discount At RedLightMan.com For Ray Peat Forum Members!
    Click Here For More Information
    Dismiss Notice

Dipalmitoylphosphatidylcholine (dppc) Protects From Pufa Cytotoxicity

Discussion in 'Scientific Studies' started by haidut, Mar 1, 2016.

  1. haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    9,970
    Gender:
    Male
    Location:
    USA / Europe
    This study shows just how "good" PUFA is for us. Human cells treat PUFA as a toxin and when faced with a PUFA overload, the cells ramp up production of the saturated DPPC as a defensive mechanism. Another strong point for the study was that it used EPA and DHA to achieve the PUFA overload, so this is also evidence against the benefit of the much touted omega-3 fats.

    Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids. - PubMed - NCBI


    "...DPPC is an indispensable component of pulmonary surfactants. In pulmonary alveolar type II cells, DPPC is synthesized in the ER and transported to lipid-rich organelles called lamellar bodies from which it is secreted into the alveolar space. In this process, ATP-binding cassette transporter A3 (ABCA3) transports DPPC that is produced by LPCAT1 into lamellar bodies (53). LPCAT1 is also expressed in other tissues where ABCA3 is not expressed, such as retina and spleen (32, 54 – 56), suggesting that the DPPC produced by LPCAT1 is not secreted by the cells. However, the roles of DPPC in those tissues are not well understood. In the present study, we demonstrated that, when mammalian cells in culture are loaded with PUFAs, they produce DPPC via LPCAT1 and that LPCAT1 knockdown markedly enhances PUFA-induced UPR and apoptosis. These results suggest that DPPC protects against cytotoxicity induced by excess PUFAs."
     
  2. Texon

    Texon Member

    Joined:
    Nov 28, 2016
    Messages:
    107
    Gender:
    Male
    Do you think this could this be safely combined with Meldonium?
     
  3. OP
    haidut

    haidut Member

    Joined:
    Mar 18, 2013
    Messages:
    9,970
    Gender:
    Male
    Location:
    USA / Europe
    Don't see why not. They have different modes of action. Meldonium would block the oxidation of that PUFA, while the saturated PC should reduce PUFA levels in the cell. So, even if it is released in the circulation it would do less damage.