After reading this excellent overview, https://www.zrtlab.com/blog/archive/difference-dhea-dheas-brain-health/,
I distilled some its contents to this:
Topical DHEA goes directly into the bloodstream and does not undergo first-pass metabolism through the liver (no sulfation). It then crosses into the brain and is converted to DHEA-S in the brain. DHEA-S cannot cross into the brain.
Troche (sublingual) DHEA goes directly into the bloodstream and does not undergo first-pass metabolism through the liver (no sulfation). It then crosses into the brain and is converted to DHEA-S in the brain.
Oral DHEA undergoes first pass metabolism in the liver where it is converted to DHEA-S (sulfated). It then cannot cross into the brain, but is available to other tissues.
DHEA = dehydroepiandrosterone
DHEA-S = dehydroepiandrosterone sulfate - 98% of DHEA in the body is DHEA-S
So, does the above suggest that, if one is going to take DHEA, that a combo of topical/troche AND oral is the best option, to get a mix of DHEA and DHEA-S in the body and the brain?
Paul
I distilled some its contents to this:
Topical DHEA goes directly into the bloodstream and does not undergo first-pass metabolism through the liver (no sulfation). It then crosses into the brain and is converted to DHEA-S in the brain. DHEA-S cannot cross into the brain.
Troche (sublingual) DHEA goes directly into the bloodstream and does not undergo first-pass metabolism through the liver (no sulfation). It then crosses into the brain and is converted to DHEA-S in the brain.
Oral DHEA undergoes first pass metabolism in the liver where it is converted to DHEA-S (sulfated). It then cannot cross into the brain, but is available to other tissues.
DHEA = dehydroepiandrosterone
DHEA-S = dehydroepiandrosterone sulfate - 98% of DHEA in the body is DHEA-S
So, does the above suggest that, if one is going to take DHEA, that a combo of topical/troche AND oral is the best option, to get a mix of DHEA and DHEA-S in the body and the brain?
Paul