Pregnenolone, Progesterone, DHEA supplementation advice

Vedder28

Member
Joined
Jan 28, 2021
Messages
6
A question for people who may relate to my state of being:

I'm 46 and have been experiencing general fatigue and brain fog for some time now. Low libido as well. My sleep has also been crap for some time. I usually wake 3-4 times a night, poor sleep quality, and also urinate quite often in the middle of the night.

A week ago I started taking 50mg pregnenolone in the evening and I have experienced positive effects. My sleep is much better, I probably only wake up once a night. Last night I went to bed at midnight and woke up at 6am...slept straight through. That has not happened in years.

Since starting the 50mg Pregnenolone (orally) I also have noticed the brain fog is much better and I have more energy during the day. I've also noticed that I wake up with erections like I was in my mid 20's or something. So all in all, very positive effects in the first week!

My question: I'm looking to test out supplementing with Progesterone +DHEA to see if that helps even further. Is there an issues trying that combo out in addition to the pregnenolone? I have slowly (very slowly) been losing my hair for the past 20 years, so I don't want to speed that process up...rather, I'm looking to stop it. I see conflicting stories on here with progesterone and DHEA and hair loss. I was thinking starting with a small does of the Progesterone +DHEA...no more that 2-3mg of the DHEA, maybe a 2-3 times a week. Or maybe I should use Pansterone only a few times a week and continue with the oral 50mg of pregnenolone on the other days?

Anyone have any experience with this or thoughts?
 

Arnold Grape

Member
Joined
Jan 24, 2017
Messages
584
Location
Upstate
I would search for the Pansterone thread since it is a combination of prog and dhea. There is a lot of discussion about the optimal dosage, experiences, etc.
 

Beastmode

Member
Joined
Feb 7, 2017
Messages
676
A question for people who may relate to my state of being:

I'm 46 and have been experiencing general fatigue and brain fog for some time now. Low libido as well. My sleep has also been crap for some time. I usually wake 3-4 times a night, poor sleep quality, and also urinate quite often in the middle of the night.

A week ago I started taking 50mg pregnenolone in the evening and I have experienced positive effects. My sleep is much better, I probably only wake up once a night. Last night I went to bed at midnight and woke up at 6am...slept straight through. That has not happened in years.

Since starting the 50mg Pregnenolone (orally) I also have noticed the brain fog is much better and I have more energy during the day. I've also noticed that I wake up with erections like I was in my mid 20's or something. So all in all, very positive effects in the first week!

My question: I'm looking to test out supplementing with Progesterone +DHEA to see if that helps even further. Is there an issues trying that combo out in addition to the pregnenolone? I have slowly (very slowly) been losing my hair for the past 20 years, so I don't want to speed that process up...rather, I'm looking to stop it. I see conflicting stories on here with progesterone and DHEA and hair loss. I was thinking starting with a small does of the Progesterone +DHEA...no more that 2-3mg of the DHEA, maybe a 2-3 times a week. Or maybe I should use Pansterone only a few times a week and continue with the oral 50mg of pregnenolone on the other days?

Anyone have any experience with this or thoughts?

Seeing that you're getting positive results with pregnenolone, you'll be able to discern if the DHEA addition contributes positively or not. Definitely the best way to experiment in my experience. You might want to play with the pregnenolone amount before you even consider the DHEA addition.

I take 100 mg of pregnenolone every morning and dhea not long afterward. I think it's worth testing it out orally (like you mentioned with progresterone) if you don't have a sensitive stomach or topically dissolved in vitamin e or olive oil. Topically Peat has told me to use about 10 times more as only up to 10% of the solution gets into the system.
 

baccheion

Member
Joined
Jun 25, 2017
Messages
1,805
One symptom of progesterone deficiency is MPB. With it happening that slowly, I'll mention melatonin. Heh. Sustained-release. Perhaps explicitly supplementing progesterone will also work. There's also megadose melatonin (see: Jeff T. Bowles).
 

Vedder28

Member
Thread starter
Joined
Jan 28, 2021
Messages
6
Seeing that you're getting positive results with pregnenolone, you'll be able to discern if the DHEA addition contributes positively or not. Definitely the best way to experiment in my experience. You might want to play with the pregnenolone amount before you even consider the DHEA addition.

I take 100 mg of pregnenolone every morning and dhea not long afterward. I think it's worth testing it out orally (like you mentioned with progresterone) if you don't have a sensitive stomach or topically dissolved in vitamin e or olive oil. Topically Peat has told me to use about 10 times more as only up to 10% of the solution gets into the system.
yes, I currently take preg orally. I was actually thinking progesterone topically, but can try orally as well. Can the Idealab supps be taken orally if desired?
 

Vedder28

Member
Thread starter
Joined
Jan 28, 2021
Messages
6
One symptom of progesterone deficiency is MPB. With it happening that slowly, I'll mention melatonin. Heh. Sustained-release. Perhaps explicitly supplementing progesterone will also work. There's also megadose melatonin (see: Jeff T. Bowles).
Thank you! I've actually read Bowles Vit D book a while back, I will have to look into melatonin. I do take 3mg before bed most nights.
 

Beastmode

Member
Joined
Feb 7, 2017
Messages
676
yes, I currently take preg orally. I was actually thinking progesterone topically, but can try orally as well. Can the Idealab supps be taken orally if desired?
I wouldn't take the pansterone orally, but that's my preference. I also don't mess with the DMSO much either which is why I just take the dhea with olive oil and pregnenelone (and progrest-e at times) orally.
 

IVILA

Member
Joined
Dec 1, 2020
Messages
114
Seeing that you're getting positive results with pregnenolone, you'll be able to discern if the DHEA addition contributes positively or not. Definitely the best way to experiment in my experience. You might want to play with the pregnenolone amount before you even consider the DHEA addition.

I take 100 mg of pregnenolone every morning and dhea not long afterward. I think it's worth testing it out orally (like you mentioned with progresterone) if you don't have a sensitive stomach or topically dissolved in vitamin e or olive oil. Topically Peat has told me to use about 10 times more as only up to 10% of the solution gets into the system.
what if your dhea levels are low before adding any of these? Wouldn't jumping straight to dhea at a small dose (5mg) be good since your not sure how much of pregnenolone will convert to dhea if you supplement with p5.
 

bzmazu

Member
Joined
Oct 29, 2015
Messages
1,556
I would search for the Pansterone thread since it is a combination of prog and dhea. There is a lot of discussion about the optimal dosage, experiences, etc.
Did you mean preg and dhea?
 

Beastmode

Member
Joined
Feb 7, 2017
Messages
676
what if your dhea levels are low before adding any of these? Wouldn't jumping straight to dhea at a small dose (5mg) be good since your not sure how much of pregnenolone will convert to dhea if you supplement with p5.
My dhea levels are on the low end. I'm not concerned about it personally. I'm more about how I consistently feel.
 

IVILA

Member
Joined
Dec 1, 2020
Messages
114
My dhea levels are on the low end. I'm not concerned about it personally. I'm more about how I consistently feel.
yeah but if you actually have most of the symptoms of dhea deficiency and feel like your not at your highest potential, then supplementing pregnenolone may not help all that much rather than adding in some dhea as well, am I right?
 

Beastmode

Member
Joined
Feb 7, 2017
Messages
676
yeah but if you actually have most of the symptoms of dhea deficiency and feel like your not at your highest potential, then supplementing pregnenolone may not help all that much rather than adding in some dhea as well, am I right?
In my direct experience, pregnenolone alone doesn't give me the androgenic boost like DHEA when taken alone. I get more of a mood boost that's steady throughout the day with pregnenolone. I do the basics really consistently (low pufa, calcium intake, etc) so I tend to notice subtle differences from any supplement I take. I'm 42 so the "youth hormones" are part of my daily stack. Progest-e on most days (1-3 drops) depending on when I need it.
 
Similar threads
Thread starter Title Forum Replies Date
D How Much Of Pregnenolone Converts To DHEA And Progesterone? Pregnenolone 1
Gohan Progesterone/pregnenolone/dhea Supplements Ask For Help or Advice 7
M Pregnenolone/progesterone/dhea Hormones 9
haidut Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging Scientific Studies 29
haidut Pregnenolone, Progesterone, DHEA Increase Breast Size In Females Scientific Studies 76
charlie Progesterone Pregnenolone & DHEA - Three Youth-Associated Articles & Newsletters 1
E Can Pregnenolone replace Progesterone temporarily during Pregnancy? Female Issues 1
ddjd progesterone causing headaches + poor sleep. pregnenolone completely relieves symptoms Ask For Help or Advice 11
haidut’s labrat Your experience with progesterone, T3/T4 and pregnenolone Health 16
Cecilia L. High Pregnenolone, High Progesterone, High Estradiol, Low D Female Issues 13
B Impact From 25mg Pregnenolone Oral Daily On Progesterone And DHT Levels? Hormones 1
B FDA Ban On Pregnenolone And Progesterone? Breaking News 3
haidut Pregnenolone Is As Potent As Progesterone As An (irreversible) Aromatase Inhibitor Scientific Studies 32
C Pregnenolone & Progesterone Side Effects Hormones 10
M Pregnenolone Vs Progesterone Vs 5-dhp For Reducing Stress Hormones 10
biggirlkisss Difference Between Progesterone And Pregnenolone Ask For Help or Advice 3
haidut Cortisol/Estrogen Impair Fertility; Progesterone/Pregnenolone Improve It Scientific Studies 7
gilson dantas Pregnenolone That Does Not Increase Progesterone Pregnenolone 91
P Are There Ways To Improve Progesterone And Pregnenolone Without Supplementing With It? Diet 3
P Pregnenolone Vs Progesterone For Benzo Withdrawal/panic Mental Issues 6
Elchapchapchapo Anyone Tried Pregnenolone / Progesterone Alongside A Aromatase Inhibitor? Hormones 26
haidut Pregnenolone & Progesterone Are Both Agonists Of The Androgen Receptor Scientific Studies 24
gilson dantas Progesterone And Pregnenolone - One Example Of Protocol Supplements, Pharmaceutical Drugs 20
S How To Raise Cholesterol, Pregnenolone, Progesterone And Related Neurosteroids Ask For Help or Advice 5
haidut How Pregnenolone And Progesterone Raise Metabolism Thyroid and Hormones 12
A Progesterone Or Pregnenolone For Women Hormones 2
haidut Pregnenolone, Progesterone And Androsterone Are Aromatase Inhibitors Scientific Studies 118
haidut Caffeine Increases Pregnenolone & Progesterone In The Brain Scientific Studies 77
H Progesterone Or Pregnenolone For Men? Hormones 28
R Pregnenolone & Progesterone together? Hormones 24
mandance Progesterone Or Pregnenolone For Men? Progesterone 7
U Pregnenolone is like a magic pill for me Ask For Help or Advice 5
N Pregnenolone Pregnenolone 0
F Could Pregnenolone be the reason why I feel bad on TRT? (estrogen antagonism?) Ask For Help or Advice 33
O Pregnenolone Powder Won't Dissolve in DMSO Supplements, Pharmaceutical Drugs 3
F Pregnenolone & or DHEA on TRT for anxiety&hair loss Ask For Help or Advice 4
M Pregnenolone supplementation causing hairloss Pregnenolone 10
Epistrophy Pregnenolone + Testosterone Base = All natural pain killer Experiments 24
deliciousfruit Pregnenolone makes me suicidal Ask For Help or Advice 19
pauljacob Pregnenolone Gave Me Vertigo Pregnenolone 10
deliciousfruit Is pregnenolone safe for adolescents? Supplements, Pharmaceutical Drugs 4
haidut Oral pregnenolone as hormone replacement therapy (HRT) in humans Scientific Studies 16
ddjd ways to increase CYP11A activity other than K2MK4? Cholesterol→Pregnenolone Ask For Help or Advice 11
O Those Who Tried Oral Pregnenolone: Did You Notice A Facelift Effect? Polls 6
pauljacob Can I Break Open A Niacinamide, Pregnenolone Capsule? Supplements, Pharmaceutical Drugs 4
cjmorin Pregnenolone Hair Fall? Hair & Nails 16
cjmorin Pregnenolone Hair Fall? Hair & Nails 0
K I Took 100mg Pregnenolone ED For Years - Please Help Me Supplements, Pharmaceutical Drugs 64
E Pregnenolone Solo Ask For Help or Advice 5
B Central Serous Retinopathy / (Piracetam/Pregnenolone/TRT/Cortison) Health 21

Similar threads

Top