DHEA - Oral or Sublingual or Topical?

[AinmAnseo]

After reading this excellent overview, https://www.zrtlab.com/blog/archive/difference-dhea-dheas-brain-health/,
I distilled some its contents to this:
Topical DHEA goes directly into the bloodstream and does not undergo first-pass metabolism through the liver (no sulfation). It then crosses into the brain and is converted to DHEA-S in the brain. DHEA-S cannot cross into the brain.
Troche (sublingual) DHEA goes directly into the bloodstream and does not undergo first-pass metabolism through the liver (no sulfation). It then crosses into the brain and is converted to DHEA-S in the brain.
Oral DHEA undergoes first pass metabolism in the liver where it is converted to DHEA-S (sulfated). It then cannot cross into the brain, but is available to other tissues.

DHEA = dehydroepiandrosterone
DHEA-S = dehydroepiandrosterone sulfate - 98% of DHEA in the body is DHEA-S

So, does the above suggest that, if one is going to take DHEA, that a combo of topical/troche AND oral is the best option, to get a mix of DHEA and DHEA-S in the body and the brain?
Paul

 

[Rinse & rePeat]

Don’t forget the natural form of DHEA….

“Orgasms improve blood flow to the brain and raise DHEA levels (remember the chemical that promotes bone health and tissue repair?), improving brain function and memory. It is also associated with better cognition and potentially less dementia as you age.”

Health Benefits of Orgasms for Women

Orgasms don’t just feel good – they are good for you! Here are some of the many ways orgasm can contribute to good health and well-being for women. Making sexual pleasure part of your self-care routine could pay off in many ways.When it comes to sexual pleasure, no two women are alike. For some...

www.thebodyagency.com

 

[learnedhelpless]

Don’t forget the natural form of DHEA….

“Orgasms improve blood flow to the brain and raise DHEA levels (remember the chemical that promotes bone health and tissue repair?), improving brain function and memory. It is also associated with better cognition and potentially less dementia as you age.”

Health Benefits of Orgasms for Women

Orgasms don’t just feel good – they are good for you! Here are some of the many ways orgasm can contribute to good health and well-being for women. Making sexual pleasure part of your self-care routine could pay off in many ways.When it comes to sexual pleasure, no two women are alike. For some...

www.thebodyagency.com

This is very true: orgasms increased the DHEA/cortisol ratio tremendously. However, the testosterone to cortisol ratio was lowered.
Here is the study:

Sci-Hub | ENDOCRINE EFFECTS OF MASTURBATION IN MEN. Journal of Endocrinology, 70(3), 439–444 | 10.1677/joe.0.0700439

 

[learnedhelpless]

Topical I think is the best, as it goes through the skin first - the skin contains lots of steroidgenic enzymes, like 5- Alpha reductase. this leads to more DHT and less estrogen from topical use.

 

[AinmAnseo]

Topical I think is the best, as it goes through the skin first - the skin contains lots of steroidgenic enzymes, like 5- Alpha reductase. this leads to more DHT and less estrogen from topical use.

Thanks.
Would the same be true of pregenolone? Topical is best, because of what you said above? I would want preg to turn into a healthy mix of progesterone and DHEA.

 

[learnedhelpless]

Thanks.
Would the same be true of pregenolone? Topical is best, because of what you said above? I would want preg to turn into a healthy mix of progesterone and DHEA.

Pregnenolone topically, goes less into progesterone, Haidut said.

 

[AinmAnseo]

Pregnenolone topically, goes less into progesterone, Haidut said.

So, Pregnenolone topically, goes less into progesterone and more into DHEA?
Does that mean that Pregnenolone orally goes more into progesterone and less into DHEA?