I'm curious to hear @aguilaroja 's thoughts on dhea-s being a mere form of storage for dhea.
Thanks for the links. Btw one of the side-links was made for you: Windows into estradiol effects in Alzheimer's disease therapy. - PubMed - NCBIThis was several years ago. Now he routinely recommends DHEA, but cautions it has to be in lower doses to prevent estrogen elevation. For many people even massive pregnenolone doses do not raise DHEA because of "naturally" elevated cortisol/estrogen with age, both of which block 17,20-lyase - the crucial enzyme for DHEA synthesis.
The comment on DHEA and Alzheimer needs to be followed up with him IMO. Many subsequent studies found lower DHEA levels in Alzheimer patients and animal models show protective effect.
Neuroprotective effects of dehydroepiandrosterone (DHEA) in rat model of Alzheimer's disease. - PubMed - NCBI
A Potential Blood Test for Alzheimer’s Disease
Testosterone and DHEA are Directly Involved in Alzheimer’s Disease | Journal of Alzheimer's Disease
Direct intervention trials found mild benefit, but definitely no deterioration as a result of DHEA.
DHEA for Alzheimer’s disease