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ros

  1. haidut

    Uncoupling metabolism/OXPHOS may treat inflammatory conditions

    In several of his articles and interviews, Peat mentioned that one of the reliable signs/symptoms of low metabolism is the presence of low-grade chronic inflammation. Basically, the cell is stuck into a constant (and futile) repair process as it cannot complete it properly after discovering the...
  2. haidut

    How lipolysis may damage organs such as the heart

    It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in...
  3. haidut

    Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

    The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...
  4. haidut

    Low, Not High, Metabolism Creates Oxidative Stress

    A hugely popular tenet of the "rate of living" theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental...
  5. ScurveDream

    Tetracyclines, ROS & Light-driven Antibiotics Approach (antimicrobial Photodynamic Inactivation)

    Has anyone read/looked over this article? I've never heard of/knew this was possible until recently. Tetracyclines function as dual-action light-activated antibiotics (in vitro/incubated cells) I'll bold/quote some of the parts I thought were interesting, assuming this hasn't been...
  6. haidut

    Vitamin K May Treat Leukemia

    Another great study demonstrating both the therapeutic potential of vitamins as well as the metabolic/redox nature of cancer. As I mentioned in some of my podcasts, vitamin K2 (MK-4) is currently in clinical trials for treating/preventing a number of different cancers, especially liver cancer...
  7. haidut

    Increased Fat Oxidation Is The Cause Of Kidney Damage

    At least in diabetes, according to the study below. Peat mentioned in several of his articles and interviews that the kidney damage so commonly seen in both type I and II diabetes patients is due to increased PUFA oxidation and decreased glucose oxidation. He also said that the same mechanism...
  8. haidut

    High-dose Vitamin C Is Making A Comeback As A Treatment For Cancer

    It look like Linus Pauling may have the last laugh after all. The studies below show that high-dose IV therapy with vitamin C dramatically increases survival of several highly lethal cancers (e.g. pancreatic). Even the lead author is in disbelief and says the results are unheard of...
  9. haidut

    High Metabolism And/Or Progesterone Can Regrow Amputated Limbs

    Another great example of "synchronicity" (Synchronicity - Wikipedia) happened today. Two separate but related studies, with similar organisms, popped up today in my mailbox. One of them (at UCDavis) shows that the redox status in favor of oxidation, and thus high reactive oxygen species (ROS)...
  10. haidut

    DHEA As A Cure For Cancer

    A fascinating study, which highlights once again not only the role of one of the "youth" steroids in human health but also demonstrates that the protective/therapeutic mechanisms of DHEA against cancer are due to increase in metabolism and ROS generation. The primary restrictive mechanism on ROS...
  11. haidut

    High Metabolism Quickly Destroys / Chelates Endocrine Disruptors Like BPA

    I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists. Bpa-free Plastic Just As Dangerous As One With Bpa Plasticisers (bpa...
  12. P

    Aging As A Consequence Of Intracellular Water Volume And Density

    Aging as a consequence of intracellular water volume and density - ScienceDirect Aging as a consequence of intracellular water volume and density Author links open overlay panelDiegoBonattoaBruno CésarFeltesbJoice de FariaPolonib RedirectingGet rights and content Open Access funded by...
  13. P

    Antioxidant Effect Of Lidocaine And Procaine On Reactive Oxygen Species-induced Endothelial Dysfunct

    Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta Korean J Anesthesiol. 2010 Aug; 59(2): 104–110. Published online 2010 Aug 20. doi: 10.4097/kjae.2010.59.2.104 PMCID: PMC2926425 Antioxidant effect of lidocaine...
  14. Dan Wich

    Methylene Blue For Skin Health

    A new study (h/t Mike Lustgarten) on methylene blue for skin health: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
  15. haidut

    Lifespan / Longevity May Be Tied To Environmental Conditions

    While I do not agree with the main assertions of the author on "rate of living" theory, he does make a few very important points, including the vital importance of mitochondria and metabolism for evolution and lifespan. Also, he lists a few examples of species where lifespan doubled simply...
  16. haidut

    Linus Pauling May Have Been Vindicated - Vitamin C May Treat Cancer

    I am posting this only because Linus Pauling is so vilified and mocked by mainstream medicine. In fact, his proposal to use high doses vitamin C for cancer treatment is listed on QuackWatch as one of the greatest medical hoaxes of the 20th century. The Dark Side of Linus Pauling's Legacy Well...
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