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  1. haidut

    Mitochondrial dysfunction is a major cause of cardiovascular disease (CVD)

    At a first glance, mitochondrial dysfunction (a "functional" problem) has little in common with the build-up of plaque on arterial walls (a "structural" problem). However, as my readers know quite well, structure and function cannot be separated and a functional pathology is perfectly capable...
    • haidut
    • Thread
    • cvd heart disease inflammation metabolism mitochondria plaque ros
    • Replies: 7
    • Forum: Scientific Studies
  2. haidut

    Blocking PUFA metabolism may treat Amyotrophic Lateral Sclerosis (ALS)

    The disease ALS needs no introduction. It is perhaps the most dreaded disease in current/former athletes as it is currently considered incurable, invariably lethal, and is known to strike athletes in much higher rates than the general population. Medicine claims that about 10% of the ALS cases...
    • haidut
    • Thread
    • als inflammation leukotriene lipoxygenase lox oxidative stress pufa ros
    • Replies: 8
    • Forum: Scientific Studies
  3. haidut

    Diabetes, Alzheimer's, cancer are bioenergetic diseases; PUFA may be the cause

    The bad news for PUFA (in this case linoleic acid) just keep piling on. At this point, there is hardly a chronic condition out there that has not been linked to elevated PUFA and/or their peroxidation products. The first study below makes the argument that PUFA peroxidation byproducts (created...
    • haidut
    • Thread
    • 4-hydroxynonenal alzheimer cancer diabetes mitochondria oxphos pufa ros
    • Replies: 1
    • Forum: Scientific Studies
  4. haidut

    Reductive stress drives pathogenesis and progression of tuberculosis

    I am posting this study b/c it is one of the few I have seen lately demonstrating that even infectious diseases are metabolic in origin. Of course, a pathogen is involved as well, but as it turns out it may not be able to cause an infection by itself. For that to happen, a metabolic dysfunction...
    • haidut
    • Thread
    • etc infection inflammation oxphos ros tnf-a tuberculosis
    • Replies: 0
    • Forum: Scientific Studies
  5. MyUsernameHere

    Antioxidants causing testicular pain?

    Something really strange is going on with my body. I can't tolerate any antioxidants and haven't found anyone else with these symptoms online. Any of the following will cause testicular tightness, shrinkage, burning in groin area (with no other symptoms anywhere else): -Vitamin C (2g and above)...
  6. haidut

    Uncoupling metabolism/OXPHOS may treat inflammatory conditions

    In several of his articles and interviews, Peat mentioned that one of the reliable signs/symptoms of low metabolism is the presence of low-grade chronic inflammation. Basically, the cell is stuck into a constant (and futile) repair process as it cannot complete it properly after discovering the...
    • haidut
    • Thread
    • atpase inflammation metabolism mitochondria oxphos ros uncoupling
    • Replies: 4
    • Forum: Scientific Studies
  7. haidut

    How lipolysis may damage organs such as the heart

    It is well-known in endocrinology, and especially among doctors specializing in diabetes, that excessive lipolysis is highly detrimental not only for the overall progression of metabolic diseases like diabetes, but also for most of the organs of the patient. Lipolysis is known to be elevated in...
    • haidut
    • Thread
    • adipocytes debris fibrosis heart lipolysis mitochondria ros
    • Replies: 0
    • Forum: Scientific Studies
  8. haidut

    Metabolic (energy) deficiency may be the cause of Parkinson Disease (PD)

    The dogma that PD is just a simple dopamine deficiency manifesting in genetically vulnerable individuals is quickly becoming untenable. It is well-known among clinicians that administering dopamine precursors such as L-Dopa, or selective dopamine agonists such as pramipexole has limited...
    • haidut
    • Thread
    • deficiency energy metabolism mitochondria parkinson pd ros
    • Replies: 25
    • Forum: Scientific Studies
  9. haidut

    Low, Not High, Metabolism Creates Oxidative Stress

    A hugely popular tenet of the "rate of living" theory is that the higher the metabolic rate the more reactive oxygen species (ROS) an organism produces. ROS elevation has already been implicated in a host of chronic disease including diabetes, CVD, cancer, neurological conditions and even mental...
    • haidut
    • Thread
    • electron acceptor metabolism oxidation oxidative stress oxphos redox reduction ros
    • Replies: 6
    • Forum: Scientific Studies
  10. MetabolicTrash

    Tetracyclines, ROS & Light-driven Antibiotics Approach (antimicrobial Photodynamic Inactivation)

    Has anyone read/looked over this article? I've never heard of/knew this was possible until recently. Tetracyclines function as dual-action light-activated antibiotics (in vitro/incubated cells) I'll bold/quote some of the parts I thought were interesting, assuming this hasn't been...
  11. haidut

    Vitamin K May Treat Leukemia

    Another great study demonstrating both the therapeutic potential of vitamins as well as the metabolic/redox nature of cancer. As I mentioned in some of my podcasts, vitamin K2 (MK-4) is currently in clinical trials for treating/preventing a number of different cancers, especially liver cancer...
    • haidut
    • Thread
    • leukemia menaquinone mk-4 redox ros stem cells treat vitamin c vitamin k vitamin k2 vitamin k3
    • Replies: 2
    • Forum: Scientific Studies
  12. haidut

    Increased Fat Oxidation Is The Cause Of Kidney Damage

    At least in diabetes, according to the study below. Peat mentioned in several of his articles and interviews that the kidney damage so commonly seen in both type I and II diabetes patients is due to increased PUFA oxidation and decreased glucose oxidation. He also said that the same mechanism...
    • haidut
    • Thread
    • cause ckd damage diabetes drive failure fat burning fat oxidation fatty acid oxidation kidney kidney disease pufa ros
    • Replies: 9
    • Forum: Scientific Studies
  13. haidut

    High-dose Vitamin C Is Making A Comeback As A Treatment For Cancer

    It look like Linus Pauling may have the last laugh after all. The studies below show that high-dose IV therapy with vitamin C dramatically increases survival of several highly lethal cancers (e.g. pancreatic). Even the lead author is in disbelief and says the results are unheard of...
    • haidut
    • Thread
    • advanced ascorbic ascorbic acid cancer dehydroascorbic high-dose lung menadione methylene blue neuroblastoma ovarian oxidized pancreatic quinone redox ros treatment vitamin c vitamin k
    • Replies: 64
    • Forum: Scientific Studies
  14. haidut

    High Metabolism And/Or Progesterone Can Regrow Amputated Limbs

    Another great example of "synchronicity" (Synchronicity - Wikipedia) happened today. Two separate but related studies, with similar organisms, popped up today in my mailbox. One of them (at UCDavis) shows that the redox status in favor of oxidation, and thus high reactive oxygen species (ROS)...
    • haidut
    • Thread
    • amputated amputation dhea hydrogen peroxide limbs metabolism oxidation progesterone redox regeneration regrow ros uncoupling
    • Replies: 56
    • Forum: Scientific Studies
  15. haidut

    DHEA As A Cure For Cancer

    A fascinating study, which highlights once again not only the role of one of the "youth" steroids in human health but also demonstrates that the protective/therapeutic mechanisms of DHEA against cancer are due to increase in metabolism and ROS generation. The primary restrictive mechanism on ROS...
    • haidut
    • Thread
    • cancer cure dhea dhea-s g6pd g6pdh metabolism ros suppression treatment tumor
    • Replies: 63
    • Forum: Scientific Studies
  16. haidut

    High Metabolism Quickly Destroys / Chelates Endocrine Disruptors Like BPA

    I suspect the topic of endocrine disruptors is on many forum users' minds. We have had multiple discussions about them here, and the ability of chemicals like BPA / BPS to act as thyroid antagonists and estrogen agonists. Bpa-free Plastic Just As Dangerous As One With Bpa Plasticisers (bpa...
    • haidut
    • Thread
    • bpa chelate chelation clear destroy endocrine disruptors lllt metabolism methylene blue photodynamic therapy red light remove ros
    • Replies: 36
    • Forum: Scientific Studies
  17. P

    Aging As A Consequence Of Intracellular Water Volume And Density

    Aging as a consequence of intracellular water volume and density - ScienceDirect Aging as a consequence of intracellular water volume and density Author links open overlay panelDiegoBonattoaBruno CésarFeltesbJoice de FariaPolonib RedirectingGet rights and content Open Access funded by...
  18. P

    Antioxidant Effect Of Lidocaine And Procaine On Reactive Oxygen Species-induced Endothelial Dysfunct

    Antioxidant effect of lidocaine and procaine on reactive oxygen species-induced endothelial dysfunction in the rabbit abdominal aorta Korean J Anesthesiol. 2010 Aug; 59(2): 104–110. Published online 2010 Aug 20. doi: 10.4097/kjae.2010.59.2.104 PMCID: PMC2926425 Antioxidant effect of lidocaine...
  19. Dan W

    Methylene Blue For Skin Health

    A new study (h/t Mike Lustgarten) on methylene blue for skin health: Anti-Aging Potentials of Methylene Blue for Human Skin Longevity
    • Dan W
    • Thread
    • aging anti-aging antioxidant methylene blue ros skin study
    • Replies: 3
    • Forum: Methylene Blue
  20. haidut

    Lifespan / Longevity May Be Tied To Environmental Conditions

    While I do not agree with the main assertions of the author on "rate of living" theory, he does make a few very important points, including the vital importance of mitochondria and metabolism for evolution and lifespan. Also, he lists a few examples of species where lifespan doubled simply...
    • haidut
    • Thread
    • adversity evolution lifespan longevity metabolic rate metabolism mitochondria ros
    • Replies: 0
    • Forum: Scientific Studies
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