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Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
BMJ 2017; 359 doi: Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes (Published 22 November 2017)Cite this as: BMJ 2017;359:j5024
"Coffee consumption was more often associated with benefit than harm for a range of health outcomes across exposures including high versus low, any versus none, and one extra cup a day. There was evidence of a non-linear association between consumption and some outcomes, with summary estimates indicating largest relative risk reduction at intakes of three to four cups a day versus none, including all cause mortality (relative risk 0.83, 95% confidence interval 0.83 to 0.88), cardiovascular mortality (0.81, 0.72 to 0.90), and cardiovascular disease (0.85, 0.80 to 0.90). High versus low consumption was associated with an 18% lower risk of incident cancer (0.82, 0.74 to 0.89). Consumption was also associated with a lower risk of several specific cancers and neurological, metabolic, and liver conditions. Harmful associations were largely nullified by adequate adjustment for smoking, except in pregnancy, where high versus low/no consumption was associated with low birth weight (odds ratio 1.31, 95% confidence interval 1.03 to 1.67), preterm birth in the first (1.22, 1.00 to 1.49) and second (1.12, 1.02 to 1.22) trimester, and pregnancy loss (1.46, 1.06 to 1.99). There was also an association between coffee drinking and risk of fracture in women but not in men."
"In the most recent meta-analysis, by Grosso and colleagues, the highest exposure category (seven cups a day) of a non-linear dose-response analysis was associated with a 10% lower risk of all cause mortality (relative risk 0.90, 95% confidence interval 0.85 to 0.96),28 but summary estimates indicated that the largest reduction in relative risk was associated with the consumption of three cups a day (0.83, 0.83 to 0.88) compared with no consumption. "
Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes
BMJ 2017; 359 doi: Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes (Published 22 November 2017)Cite this as: BMJ 2017;359:j5024
"Coffee consumption was more often associated with benefit than harm for a range of health outcomes across exposures including high versus low, any versus none, and one extra cup a day. There was evidence of a non-linear association between consumption and some outcomes, with summary estimates indicating largest relative risk reduction at intakes of three to four cups a day versus none, including all cause mortality (relative risk 0.83, 95% confidence interval 0.83 to 0.88), cardiovascular mortality (0.81, 0.72 to 0.90), and cardiovascular disease (0.85, 0.80 to 0.90). High versus low consumption was associated with an 18% lower risk of incident cancer (0.82, 0.74 to 0.89). Consumption was also associated with a lower risk of several specific cancers and neurological, metabolic, and liver conditions. Harmful associations were largely nullified by adequate adjustment for smoking, except in pregnancy, where high versus low/no consumption was associated with low birth weight (odds ratio 1.31, 95% confidence interval 1.03 to 1.67), preterm birth in the first (1.22, 1.00 to 1.49) and second (1.12, 1.02 to 1.22) trimester, and pregnancy loss (1.46, 1.06 to 1.99). There was also an association between coffee drinking and risk of fracture in women but not in men."
"In the most recent meta-analysis, by Grosso and colleagues, the highest exposure category (seven cups a day) of a non-linear dose-response analysis was associated with a 10% lower risk of all cause mortality (relative risk 0.90, 95% confidence interval 0.85 to 0.96),28 but summary estimates indicated that the largest reduction in relative risk was associated with the consumption of three cups a day (0.83, 0.83 to 0.88) compared with no consumption. "
