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CFS Pathology Tied To Increased Blood Levels Of Endotoxin

haidut

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After more than a decade of denial that the "mysterious" condition CFS even exists as a physiological state, mainstream medicine may be warming up to the fact that it is not simply in patients' heads. This latest study found changes in patients' microbiome as well as elevatd levels of endotoxin in the blood. Note that even the authors of the study call the idea of CFS being purely psychological "ridiculous".

Microbiome
https://www.sciencedaily.com/releases/2016/06/160627160939.htm

"...Now, for the first time, Cornell University researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood. In a study published June 23 in the journal Microbiome, the team describes how they correctly diagnosed myalgic encephalomyeletis/chronic fatigue syndrome (ME/CFS) in 83 percent of patients through stool samples and blood work, offering a noninvasive diagnosis and a step toward understanding the cause of the disease. "Our work demonstrates that the gut bacterial microbiome in chronic fatigue syndrome patients isn't normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease," said Maureen Hanson, the Liberty Hyde Bailey Professor in the Department of Molecular Biology and Genetics at Cornell and the paper's senior author. "Furthermore, our detection of a biological abnormality provides further evidence against the ridiculous concept that the disease is psychological in origin."
 

Mufasa

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Interesting, my CFS completely went away after doing a Ray Peat inspired diet since February. I haven't taken any probiotics though. Maybe the microbiome can balance itself if you keep temps high?
 

haidut

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Interesting, my CFS completely went away after doing a Ray Peat inspired diet since February. I haven't taken any probiotics though. Maybe the microbiome can balance itself if you keep temps high?

It does get rebalanced, and supplemental thyroid, cascara/emodin, taurine, glycine, etc have all been shown to help with the rebalancing towards less pathogenic bacteria, not to mention their effects on opposing endotoxin.
 

Mufasa

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It does get rebalanced, and supplemental thyroid, cascara/emodin, taurine, glycine, etc have all been shown to help with the rebalancing towards less pathogenic bacteria, not to mention their effects on opposing endotoxin.

Ah, well I take emodin, taurine and glycine haha :) And I put red light on my thyroid daily to boost my thyroid function.
 

jayUK9779

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I went into remission for 3 years from CFS, carrot salads helped the most looking back. Now I have a hiatus hernia not many things are having such an immediate effect now :( digestion is sluggish all the way through from stomach to bowel :(
 

haidut

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haidut, I'm surprised how scarce it's the literature connecting endotoxin to motor coordination/loss of balance. Even if you search for the straight connection of inflammatory markers, you don't find much relevant information..

Yeah, and considering kids with autism (another "gut" condition) often have problems with balance the lack of research into this connection is highly suspect. I suppose the establishment does not want to go too far down the endotoxin route given the proven connection between all kinds of emulsifiers, gums, drugs (opioids, SSRI), stress, etc and endotoxin / serotonin release. They prefer to just study "microbiome imbalance" and chalk all symptoms to bad bacteria, for which if course they sell a pill with probiotics.
 

Bluebell

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This makes sense, I always feel much better after antibiotics, but it doesn't last for long.

Should we work on sealing up leaky gut as well? Though I have heard that the gut can become permeable again very quickly if the root cause is not addressed. (and I'm not sure what the root cause of leaky gut is!)
 

haidut

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This makes sense, I always feel much better after antibiotics, but it doesn't last for long.

Should we work on sealing up leaky gut as well? Though I have heard that the gut can become permeable again very quickly if the root cause is not addressed. (and I'm not sure what the root cause of leaky gut is!)

If that is your goal then things like magnesium, gelatin/glycine, theanine and anti-histamines are some of the substances shown to seal the leaky gut.
 

Mufasa

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If that is your goal then things like magnesium, gelatin/glycine, theanine and anti-histamines are some of the substances shown to seal the leaky gut.

I heard vitamin A is also important for healing a leaky gut, but I got that information from the GAPS diet, not sure how true that is.
 

haidut

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I heard vitamin A is also important for healing a leaky gut, but I got that information from the GAPS diet, not sure how true that is.

Definitely, forgot about vitamin A. It should be high on the list for people with gut and even pancreatic issues.
 

Derek

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This makes sense, I always feel much better after antibiotics, but it doesn't last for long.

Should we work on sealing up leaky gut as well? Though I have heard that the gut can become permeable again very quickly if the root cause is not addressed. (and I'm not sure what the root cause of leaky gut is!)

Zinc deficiency is a big cause. Also, there is a mucus layer throughout the whole intestines that is made up of glucose; so adequate glucose and protein are two other things to focus on. PUFA avoidance as well.
 

Bluebell

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Thanks. Taking magnesium glycinate, and glycine. Theanine gives me liver pain for some reason. Taking cypro around once a week. I need to add A. Zinc I've had too much of in the past so I'm not taking it.

Does anyone know if N-Acetylglucosamine (NAG) is a Peaty thing to take? It's supposed to help seal up the gut. I took it but wondered if it might be feeding bad bacteria.
 

Derek

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Thanks. Taking magnesium glycinate, and glycine. Theanine gives me liver pain for some reason. Taking cypro around once a week. I need to add A. Zinc I've had too much of in the past so I'm not taking it.

Does anyone know if N-Acetylglucosamine (NAG) is a Peaty thing to take? It's supposed to help seal up the gut. I took it but wondered if it might be feeding bad bacteria.

Better to get glycine and magnesium from food than to supplement. I meant getting zinc from food, not supplementing. Glutamine is probably much better than NAG. How do you know you even have a leaky gut?
 

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