I know people with IBS who swear by their morning coffee and cigarette. I am not encouraging smoking of course.
http://www.ncbi.nlm.nih.gov/pubmed/23925589
"...Development of acute colitis is reduced upon caffeine treatment. The mechanism involves the down-regulation of CHI3L1 expression and its associated bacterial interaction effect. Therefore, caffeine is proposed as a safe and economical candidate for successful IBD management."
http://www.ncbi.nlm.nih.gov/pubmed/23925589
"...Development of acute colitis is reduced upon caffeine treatment. The mechanism involves the down-regulation of CHI3L1 expression and its associated bacterial interaction effect. Therefore, caffeine is proposed as a safe and economical candidate for successful IBD management."