Interesting study on aspirin from july of last year Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory
Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
Click Here if you want to upgrade your account
If you were able to post but cannot do so now, send an email to admin at raypeatforum dot com and include your username and we will fix that right up for you.
Peat did mention that he noticed that many people had maintained their sharp minds by taking aspirin. Anecdotal of course, but still a valuable data points. He also made the recommendation of 500mg twice a day.
Sorry, it was an interview I heard years ago.that seems a high dose. Can you tell me where you heard or read Peat recommending this. Thanks.
Agreed — I’ve read that Peat takes aspirin in 5-700 mg doses, when he feels like it. 1 gram daily would be a hefty dose, although not drastically different than I’ve heard mentioned here.that seems a high dose. Can you tell me where you heard or read Peat recommending this. Thanks.
PDE4 hydrolyzes cyclic adenosine monophosphate (cAMP) to inactive adenosine monophosphate (AMP). Inhibition of PDE4 blocks hydrolysis of cAMP, thereby increasing levels of cAMP within cells.
The most potent selective inhibitors of 5α-R are:...interestingly, the effect of PEAmide was partially inhibited by finasteride, a 5α-reductase inhibitor.
This could potentially occur via PEA's PPAR-α mediated Allopregnanolone release?...interestingly, the effect of PEA was partially inhibited by finasteride, a 5α-reductase inhibitor.
a bit of a simplistic superficial analysis lolBut doesn't Agmatine also increase NO?
Agmatine
(raises eNOS • lowers nNOS, iNOS)
Progesterone
(raises eNOS • lowers iNOS, nNOS)
Aspirin
(lowers ALL - eNOS, iNOS, nNOS ~ conflicting - possibly raises eNOS)
Caffeine
(lowers eNOSi • NOS? nNOS?)
Methylene Blue
(lowers eNOS, iNOS, nNOS)
I'm not so sure about the zinc. I've seen studies where people take large doses and experienced an increase in T and DHT.The most potent selective inhibitors of 5α-R are:
- polyunsaturated fatty acids (especially linolenic acid)
- zinc
- green tea
- Riboflavin was also identified as a 5α-reductase inhibitor .[14]
- Potentially the Ganoderic acids in lingzhi mushroom
- Potentially Saw Palmetto.
I'm not so sure about the zinc. I've seen studies where people take large doses and experienced an increase in T and DHT.
Zinc supplementation (120mg twice daily) significantly increased DHT (19%), and also slightly increased testosterone (8%) in eugonadal men (490 to 750ng/dl), showing an upregulation of 5 alpha reductase even at a very high dose zinc. (30)cant remember where I saw that but read somewhere that zinc inhibits shbg to bind to estrogen. But it not testosterone so more shbg to bind to testosterone and more free estrogen. But it likely has other mechanisms tho to increase T.
it's quoted straight from the research paper. take your queries up with the authors lolI'm not so sure about the zinc. I've seen studies where people take large doses and experienced an increase in T and DHT.
I've looked through all your posts on that thread in search of agmatine dosage, perhaps I missed it? I'm currently giving my husband agmatine at approximately 750mg a day for glaucoma (roughly the examine.com suggested dosage, haven't checked again recently though). Now that I read it has anti-depressive effects I'd like to know if there's a larger dosage for that. He's recently developed gall stones, depression and bad anxiety, linked I think.a bit of a simplistic superficial analysis lol
There are nuances involved here.
It seems both agmatine & progesterone (GASP) raise eNOS; lower nNOS & iNOS.
Here's my main thread on Agmatine Agmatine - A 'Peaty' Substance With Potential?
From what i gather, there is no set agmatine dosage...I've looked through all your posts on that thread in search of agmatine dosage, perhaps I missed it?
...
Now that I read it has anti-depressive effects I'd like to know if there's a larger dosage for that.
He's recently developed gall stones, depression and bad anxiety, linked I think.
Well, the psychedelic effects are part and parcel of Agmatine's pharmacological actions! Notably Agmatine's BDNF, HT2A, AMPA, cannabinoid-modulating (via imidazoline) & HT3 blocking...Thank you so much @Sativa. I think I'll try 1g and see how that goes. I don't think psychedelic is a wise goal in this case but brain reset sounds promising. I wonder about potential for helping PTSD then. Will read more closely.