Neuron death induced by THC was inhibited by Vitamin E and Asprin

[extremecheddar]

Not sure if this has been posted yet.

http://m.jneurosci.org/content/18/14/5322.full

"THC neurotoxicity is abrogated by vitamin E as well as inhibitors of phospholipase A2 and cyclooxygenase"

"Consequently, memory defects caused by marijuana might be reduced by aspirin, indomethacin, or vitamin E. Interestingly, clinical studies indicate that elevation of prostaglandins caused by marijuana smoking can be suppressed by indomethacin (Perez Reyes et al., 1991). "

"THC enhancement of arachidonic acid release from cultured neurons and protection of neurons from THC by vitamin E supports this hypothesis."

 

[burtlancast]

Here's a 2005 article finding exactly the opposite effects of your 1998 article:

Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects​

The goal of the present study was to test the hypothesis that the potent synthetic cannabinoid HU210 is able to promote hippocampal neurogenesis, leading to the anxiolytic and antidepressant effects of cannabinoids. We demonstrate here that both HU210 and the endocannabinoid AEA promote proliferation of embryonic hippocampal NS/PCs without significant effects on their differentiation, resulting in more newborn neurons. The effects of HU210 on adult hippocampal neurogenesis were quantified in freely moving rats and were correlated with behavioral testing. We show that 1 month after chronic HU210 treatment, rats display increased newborn neurons in the hippocampal dentate gyrus and significantly reduced measures of anxiety- and depression-like behavior. Thus, cannabinoids appear to be the only illicit drug whose capacity to produce increased hippocampal newborn neurons is positively correlated with its anxiolytic- and antidepressant-like effects.

http://www.jci.org/articles/view/25509


Furthermore, here's the article describing better neurobehavioral development of newborn babies exposed to heavy cannabis concentrations by their pot smoking mothers:

Prenatal marijuana exposure and neonatal outcomes in Jamaica: an ethnographic study​

The neonates of heavy-marijuana-using mothers had better scores on autonomic stability, quality of alertness, irritability, and self-regulation and were judged to be more rewarding for caregivers.

http://www.ncbi.nlm.nih.gov/pubmed/8121737

 

[Hugh Johnson]

Since it has to do with arachidonic acid release, the different results could just be caused by a difference in diet. Even the standard chow might have changed in seven years.