HMB ly 2023

[David PS]

I did not double check the title of this thread and I cannot edit it.

July 2023

Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice - PubMed

This study underlines the importance of β-hydroxy β-methylbutyrate (HMB), a muscle-building supplement in human, in increasing mouse hippocampal plasticity. Detailed proteomic analyses reveal that HMB serves as a ligand of peroxisome proliferator-activated receptor α (PPARα), a nuclear hormone...

pubmed.ncbi.nlm.nih.gov

Abstract​

This study underlines the importance of β-hydroxy β-methylbutyrate (HMB), a muscle-building supplement in human, in increasing mouse hippocampal plasticity. Detailed proteomic analyses reveal that HMB serves as a ligand of peroxisome proliferator-activated receptor α (PPARα), a nuclear hormone receptor involved in fat metabolism, via interaction with the Y314 residue. Accordingly, HMB is ineffective in increasing plasticity of PPARα-/- hippocampal neurons. While lentiviral establishment of full-length PPARα restores the plasticity-promoting effect of HMB in PPARα-/- hippocampal neurons, lentiviral transduction of Y314D-PPARα remains unable to do that, highlighting the importance of HMB's interaction with the Y314 residue. Additionally, oral HMB improves spatial learning and memory and reduces plaque load in 5X familial Alzheimer's disease (5XFAD) mice, but not in 5XFADΔPPARα mice (5XFAD lacking PPARα), indicating the involvement of PPARα in HMB-mediated neuroprotection in 5XFAD mice. These results delineate neuroprotective functions of HMB and suggest that this widely used supplement may be repurposed for AD.

 

[DennisX]

Not everything that works in mice works in humans. HMB is a derivative of leucine. Leucine is a cheaper way to go to get HMB.

 

[David PS]

Not everything that works in mice works in humans. HMB is a derivative of leucine. Leucine is a cheaper way to go to get HMB.

Thanks for the info about leucine. It lloks like I am getting enough from my diet.

 

[Blossom]

View: https://youtu.be/yqslK6Vp0JI

Here’s an interesting 3-4 minute comment on leucine by Don Layman.

 

[David PS]

Not everything that works in mice works in humans. HMB is a derivative of leucine. Leucine is a cheaper way to go to get HMB.

It still might be worth it.

HMB health benefits, dosage, safety, side effects, and supporting evidence. | Supplements | Examine

The latest and most important research on HMB. Expert analysis on practical effects, potential risks, and more.

examine.com

All of the HMB present in the human body is derived from dietary sources of leucine, with about 5% of all dietary leucine being converted to HMB.[1] HMB is thought to help reduce muscle protein breakdown and may mediate some of the effects of leucine on muscle protein synthesis.

 

[DennisX]

Yeah that might be true but I don't like adding another derived molecule to my smoothy and paying a lot for it without human RCT trials

 

[David PS]

This study demonstrated the potential of HMB and vitamin D3 supplementation to enhance muscle strength and physical functionality in older adults, even in individuals not engaged in an exercise training program.

Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study

Abstract. The primary aim of this study was to determine whether supplementation with calcium β-hydroxy-β-methylbutyrate (HMB) and vitamin D3 (D) would enhance

academic.oup.com