Aspirin As Effective As Viagra For ED, But With Much Fewer Side Effects

[rei]

I think its effects on lowering serotonin may also be involved. Lower serotonin means better libido, and poor libido has been shown to be behind 70%+ of ED cases. Hard (pun intended) to get hard when there is no desire.
Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. - PubMed - NCBI

Moderate depletion of blood platelets around the time of the onset of lung injury lessens the subsequent development of right ventricular enlargement, suggesting a reduction in the pulmonary hypertensive response to monocrotaline pyrrole.

To me it seems that if you have enough platelets you are able to transport serotonin to the lungs more effectively for detox, but due to being poisoned the detox fails and lung damage/hypertension happens which leads to heart damage. Do lungs only detox platelet bound serotonin?

If so, then the answer seems to be aspirin's effect on platelet function. If not,then the effect is probably due to aspirin's effect on serotonin production.

 

[invictus]

@haidut, this is a fascinating post. I've been dealing with ED & low testosterone for 10 years, though I think both problems stem from a dysfunctional marriage. My wife has many emotional/psych problems, including ambivalence towards sex, though, through her own words, she communicated that she had quite an adventurous sex life long before we met. Nothing kills desire and erections, quicker, than a woman who keeps telling you she doesn't need sex, doesn't like it and can live without it. But I also have pre-diabetes, dyslipidemia and high hsCRP, much of it connected to years of non-restorative sleep, related to treatment resistant bipolar. As to why I didn't leave my wife; I've been unable to work for over a decade. Being homeless isn't a good option.

I'm taking more aspirin than I have in years, primarily because it always gave me a vaguely sick,nauseous feeling, with or without food. Don't encounter that, much, now. I've experimented with research grade liquid tadalifil but the sides(GI disturbances, nasal congestion, low grade headache and general malaise) make it a less than desirable experience, even though it improved erections. I'll be taking aspirin, daily, and report back on how I'm doing, even if my wife doesn't want it, lol.

@stevrd, your experiences made me laugh with joy. I'm 69 but I want to be a horny, hard 16 year old once again or as close as I can get!

 

[Rosiemax14]

If you could share which asprin and the daily dose and if there is a better time to take it?
thank you

 

[stevrd]

@haidut, this is a fascinating post. I've been dealing with ED & low testosterone for 10 years, though I think both problems stem from a dysfunctional marriage. My wife has many emotional/psych problems, including ambivalence towards sex, though, through her own words, she communicated that she had quite an adventurous sex life long before we met. Nothing kills desire and erections, quicker, than a woman who keeps telling you she doesn't need sex, doesn't like it and can live without it. But I also have pre-diabetes, dyslipidemia and high hsCRP, much of it connected to years of non-restorative sleep, related to treatment resistant bipolar. As to why I didn't leave my wife; I've been unable to work for over a decade. Being homeless isn't a good option.

I'm taking more aspirin than I have in years, primarily because it always gave me a vaguely sick,nauseous feeling, with or without food. Don't encounter that, much, now. I've experimented with research grade liquid tadalifil but the sides(GI disturbances, nasal congestion, low grade headache and general malaise) make it a less than desirable experience, even though it improved erections. I'll be taking aspirin, daily, and report back on how I'm doing, even if my wife doesn't want it, lol.

@stevrd, your experiences made me laugh with joy. I'm 69 but I want to be a horny, hard 16 year old once again or as close as I can get!

Thanks for your input. Yeah I got lucky with my wife with sex but we are both about 30 now so still young. I hope it lasts. I think sex is mostly a mindset. If one is determined to have a sex life nothing should stop him. Even ed. Ever hear of soft entry? Too many people let ed put them out of the game, but I totally understand having an unwilling wife is surely a killer.

I tried viagra a few times years ago and hated the feeling it gave me. The veins in my feet felt like they were going to burst. And my erection felt like a balloon, lacked sensitivity and wasn't at all satisfying. I was erect but it didnt increase my libido at all, quite the opposite. I had been reading ray peat then as well. That's when I knew that good quality erections depend on CO2 and not NO.

 

[stevrd]

If you could share which asprin and the daily dose and if there is a better time to take it?
thank you

I take 325mg aspirin a regular tablet, along with 1mg vitamin k2, since aspirin depletes it. I take it at night due to the benefits it has on preventing thrombosis and platelet aggregation while sottong or laying for long periods.

 

[Alpha]

Be VERY careful taking Aspirin and Tadalafil together.

I did that for a few days alternating between them every day, and I got a terrible side effect. My eyelid and eye area ballooned up in some sort of fluid retention with a feeling of high pressure in the area. I don't remember the exact name of the cause, but using both increases activation of a certain enzyme pathway that causes it.

I'll edit the post if I can find the name.

 

[invictus]

@stevrd: You're welcome. If I restore reliable function she might be more responsive, even if it's just now and then.

 

[stevrd]

@stevrd I sometimes get hard during kissing, but when it comes to getting to the act of sex, it sometimes fails. I blame porn for this, which I am trying to stay away from as much as possible.
My T was in the 300 - 400 range before peating, excited for the near future, I'd be thrilled to get it over 700 ng/dL.

My erections improved significantly while peating and I still was in the 400 to 500 range at the time. I cant stress enough how as long as one isn't hypogonadal or less than 200 to 300, test levels don't matter much for erection function. I'm in the 500 to 600 range now and couldn't he happier, great libido and erections, recovery from workouts is great, no issues at all.

This study is a pretty comprehensive review on testosterone's relationship with ED:
Relationship Between Testosterone and Erectile Dysfunction

Here is the summary:
Hypogonadism is the most common cause for endocrinopathy leading to ED, although the endocrine disorders themselves are some of the rarest of all causes of ED. Most men experience a lowering of their serum testosterone levels with age, but these levels usually are not low enough to induce ED. When hypogonadism is suspected of causing ED, treatment with exogenous androgens is recommended if there are no contraindications to its use in this setting. If the ED does not resolve after a finite time of treatment with the exogenous testosterone, other causes (vascular and/or neurologic) must be suspected. Even men with normal serum testosterone levels may require or request exogenous testosterone therapy because of other constitutional symptoms.53 Patients on long-term androgen therapy require follow-up of their PSA, hematocrit, and liver enzymes about every 6 to 12 months.

There are clearly other factors in ED then testosterone. Haidut, posted a study somewhere on here that finasteride destroys the pudendal nerve at the perinium, leading to ED, not to mention it's lasting effects on 5ar. So this explains why men with post finasteride syndrome can have normal or even high testosterone levels, but still have ED.

Dr. Peat emailed me something years ago when I was incessantly researching ways to increase testosterone. I can't locate the exact quote at this time, but he said something like "fix thyroid, eat a carrot salad, and maybe take pregnenolone and then let testosterone fall where ever it does."

Basically this means, as long as thyroid is working well, and the gut is not producing massive amounts of serotonin, then the amount of androgens one produces on his own should be enough for erection function. Finally, if something is interfering with cholesterol to pregnenolone conversion, a little pregnenolone can help.

For the longest time I kept trying to find ways to raise testosterone until I experimented with things like hcg and aromasin to bring test levels >1000 and didn't feel any better. It wasn't until I worked on diet and thyroid/gut that things started improving and that was when I was in the 400 range.

The other thing I noticed is that eating a high fat, high carb, moderate to low protein diet helped tremendously. Studies show lowering either fat or carbs can lead to low androgens. Over the years, nearly every time I experimented with a high protein diet, having to decrease one of the other macros in order to get in more protein, I always experienced worse erections and libido problems. Carbs are the most important macronutrient from a percentage standpoint, and go a long way in increasing test levels.

 

[GreekDemiGod]

@stevrd Thanks for the response. So Aspirin should help with it, I just have to give it time.
Just registered my highest temperature since peating (36.9 at midnight though), so I'm closer and closer to optimal thyroid function.
As for gut health, I do have a lot to improve.
High carb( > 45%), moderate protein, moderate fat (25 - 30%) is the best macros for T levels from my research, though I do know lower fat is preferred around here.

 

[stevrd]

@stevrd Thanks for the response. So Aspirin should help with it, I just have to give it time.
Just registered my highest temperature since peating (36.9 at midnight though), so I'm closer and closer to optimal thyroid function.
As for gut health, I do have a lot to improve.
High carb( > 45%), moderate protein, moderate fat (25 - 30%) is the best macros for T levels from my research, though I do know lower fat is preferred around here.

There is research showing that reducing fat from 40 to 20 percent of calories showed a significant drop in testosterone, but it wasn't as severe when pufa was substituted for saturated fat. And reducing fat intake is nowhere near as detrimental as reducing carbs. For me, around 30 percent fat, 20 percent protein and 50 percent carbs works best. Sometimes I eat higher fat if my appetite calls for it. I cant do protein shakes or eat very lean foods without carbs and or fat to balance it out or I get an adrenaline or cortisol response and concomitant hypoglycemia from insulin stimulation without the glucose to manage blood sugar.

 

[Insaneacinamide]

@haidut Interesting post.

To you or anyone else: Trazodone has some effect on erections, even causing priapism in men/women(long lasting erection) which is rare.
Though some report betting nocturnal/morning erections. It's also off label for ED.
Trazodone - Wikipedia
It's said likely due to its antagonism at α-adrenergic receptors 1a and 2a.
Though it also has effects on other things like an antagonist at h1 histamine, serotonin 2a, partial antagonist at serotonin 1a and 1c.
1) Any type other type of serotonin or alpha antagonists that can effect erections?

It would be interesting to be able to try other substances(alpha and serotonin antagonists) to compare it to.
Not sure the % of these neuro antagonists effecting erections compared to other things like hormones or viagara/cialis type meds. Though it seems there are quite a few factors that can cause ED.

2) Could endotoxin/inflammation have any effect on erections?

 

[stevrd]

@haidut Interesting post.

To you or anyone else: Trazodone has some effect on erections, even causing priapism in men/women(long lasting erection) which is rare.
Though some report betting nocturnal/morning erections. It's also off label for ED.
Trazodone - Wikipedia
It's said likely due to its antagonism at α-adrenergic receptors 1a and 2a.
Though it also has effects on other things like an antagonist at h1 histamine, serotonin 2a, partial antagonist at serotonin 1a and 1c.
1) Any type other type of serotonin or alpha antagonists that can effect erections?

It would be interesting to be able to try other substances(alpha and serotonin antagonists) to compare it to.
Not sure the % of these neuro antagonists effecting erections compared to other things like hormones or viagara/cialis type meds. Though it seems there are quite a few factors that can cause ED.

2) Could endotoxin/inflammation have any effect on erections?

Thanks for sharing. It's not surprising that anti-adrenergic type drugs have a benefit to treating ED as elevated adrenaline results in pulling blood from the periphery to the core of the body. This is why increasing adrenaline while at rest can result in cold hands, feet, and genitals. If you've ever experienced cold genitals while exercising you know what I mean. I presume a substance such as L-theanine with it's anti-adrenergic properties might help in this regard, but unfortunately there are a lot of reports of people stating it makes their libido/erections worse.

 

[Frankdee20]

I think PE is due to excess adrenaline. Increasing serotonin will lower adrenaline but not in healthy way, it's just making you more sluggish. The real solution would be to increase GABA via better thyroid, red light, salt, etc.

Sorry to get off topic people, I think it has something to do with the physical nerve endings on the penis itself, specifically the glans, or foreskin. It is like they are too sensitive.

 

[Insaneacinamide]

Thanks for sharing. It's not surprising that anti-adrenergic type drugs have a benefit to treating ED as elevated adrenaline results in pulling blood from the periphery to the core of the body. This is why increasing adrenaline while at rest can result in cold hands, feet, and genitals. If you've ever experienced cold genitals while exercising you know what I mean. I presume a substance such as L-theanine with it's anti-adrenergic properties might help in this regard, but unfortunately there are a lot of reports of people stating it makes their libido/erections worse.

Ya for sure! Good points there about the blood.
I checked l-theanine on a few sites (wiki/drugbank) though none of them showed that it had any effect on alpha receptors. No idea about that one.

Though I did come across that there is ED therapy with alpha blockers just now. Looks like things like binding affinity plays some role, and also there seems to be more alpha sites a1a, a1b, a1c, a1d, a2a, a2b, a2c.
Moxisylyte - Wikipedia
Phentolamine - Wikipedia
Yohimbine - Wikipedia

 

[stevrd]

Ya for sure! Good points there about the blood.
I checked l-theanine on a few sites (wiki/drugbank) though none of them showed that it had any effect on alpha receptors. No idea about that one.

Though I did come across that there is ED therapy with alpha blockers just now. Looks like things like binding affinity plays some role, and also there seems to be more alpha sites a1a, a1b, a1c, a1d, a2a, a2b, a2c.
Moxisylyte - Wikipedia
Phentolamine - Wikipedia
Yohimbine - Wikipedia

I think theanine has more of an effect on increasing GABA and decreasing serotonin/cortisol than on the alpha receptors. The studies I reviewed on theanine suggest that it prevents the rise of epinepherine. In other words, it's acting more as an adaptogenic stress preventing substance than actually inhibiting the a-sites. It might have an effect on adrenaline through a secondary mechanism.

I learned about theanine's anti-stress and catacholamine modulating effects here.
Theanine Stops And Reverses The Stress Reaction (cortisol, Noradrenalin, Dopamine)

Personally, I will stay away from theanine, as I never experienced any benefits from it. If you search the forum you will find more negative reviews than positive. But it is interesting considering the topic of discussion.

Interesting about yohimbine. I wonder if those reports of it acting like a natural viagra are true. Never tried it myself.

 

[Insaneacinamide]

@stevrd Ahh thx for the info. I've heard people say they had good libido (maybe better erections also) on various gaba type substances. Perhaps it might be the higher libido/desire that gives them a better erection?
I've tried yohimbine bark in an alcohol tincture, and bark in capsules... and it didn't do much. Though maybe they use yohimbine hcl verison, which I've never tried. No idea however.

To anyone: a buddy of mine used cialis, and clenbuterol(a beta agonist). Said he had great stamina and erection.
From wiki "It is commonly used for smooth muscle-relaxant properties as a bronchodilator and tocolytic."
Any thoughts on beta agonists to help erections? Anyone experience better erections on beta agonists or beta blocker?

 

[oburns]

A bit confused, too much Aspirin can mess up my erections sometimes. I have even seen it mentioned on the forum that it lowers Histamine, and can mess up Libido as well.

Depends on what else you are adding/removing from your diet. If you are doing supplements, protein powders, fish oils etc.

 

[Frankdee20]

Depends on what else you are adding/removing from your diet. If you are doing supplements, protein powders, fish oils etc.

No fish oil, lol. Occasional E, K1,2, D3, Mag, B Complex, C, eating liver for A, eggs, meat, etc.

 

[Progesterone]

Aspirin increases sensitivity for me as well, but in a good way. Not premature ejaculation, as I'm able to control it. My issue for the longest time was delayed ejaculation during intercourse. It became exhausting just to reach climax. Many people think this is a good thing, but after a while even women complain of it because most (normal) women have a limit to how long they can stand. Aspirin helps a great deal in this regard.

Are you circumcised?

 

[Patty]

Yet another blockbuster drug may turn out to be nothing more than a well-marketed gimmick, which while not entirely a scam can be replaced with cheaper, safer alternatives that also have much lower potential for side effects. The drug in question is Viagra, and the humble, just-as-effective substitute is aspirin. A group of doctors out of Turkey has been conducting studies comparing the effects of aspirin on sexual performance in men diagnosed with erectile dysfunction (ED). The experiments go back at least a decade but up until 2018 they were done primarily on animals. However, the last two studies coming out of that group are with humans and the results are quite impressive, especially considering that the aspirin dose was just 100mg daily and the treatment lasted for only 6 weeks. An additional aspect that the popular press articles do not discuss is the potential for aspirin to actually be a so-called "disease modifying therapy". ED is known to be caused by cardiovascular disease (CVD). While Viagra has never been shown to improve the pathology of CVD and no such claims have ever been made about that drug, aspirin HAS been shown to have a long term beneficial effect on CVD. As such, the benefits of aspirin may actually be much longer-lasting and may even be (dare I say) "curative". In other words, after those 6 weeks of aspirin therapy the improvements in erection and sexual function may very well be persistent compared to the people taking Viagra. And as the study found, even if one has to use Viagra, taking aspirin with it significantly lowers the risk of side effects from that drug. Not bad for a tiny pill with more than 3 thousand years of human medical history, and dirt-cheap compared to Viagra.

Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo... - PubMed - NCBI
Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: a com... - PubMed - NCBI

"...RESULTS: The changes in IIEF-EF scores after treatment were 7.2 ± 4.4, 7.3 ± 4.3, 7.5 ± 4.4, and 2.0 ± 4.6 for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.0204), respectively. The change in SEP-2 ratios after treatment were 36.6%, 36.9%, 41.7%, and 9.4% for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.2925), respectively. The change in SEP-3 ratios after treatment was 46.6%, 49.2%, 53.7%, and 12.5% for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.1456), respectively. In group 2 [tadalafil], both the number of patients who reported side effects (p < 0.0001) and stopped using the drug due to side effects (p < 0.05) were significantly higher than the control and others groups. CONCLUSIONS: Successful results were obtained by tadalafil and aspirin monotherapy and tadalafil + aspirin combination therapy in patients with VED. However, the least side effect was observed in the tadalafil + aspirin group. Aspirin can be used alone in the treatment of patients with VED, or combined with tadalafil to reduce side effects and increase success."

Could you improve your love life with an aspirin?

"...DAILY aspirin is as effective as Viagra-type drugs for impotence, according to a study. Doctors at Istanbul Medipol University in Turkey divided 336 men with erectile dysfunction into four groups and gave them either aspirin, tadalafil (a Viagra-like drug), tadalafil plus aspirin, or a placebo, according to the study published in International Urology and Nephrology. Taken separately, both drugs increased sexual activity by more than a third, and together, also removed headaches associated with tadalafil. Researchers say aspirin ‘thins' the blood, so more can flow into the genital area, and may help the 70 per cent of men whose impotence has a vascular cause."

Fantastic submission. Would really love to try this out, maybe ASPIRIN only. But one problem: How / where to get the ideal Asprin?

Appreciate your recommendations.