Human Study - Aspirin Effective For Erectile Dysfunction (ED)

haidut

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I am starting to wonder if there is anything aspirin can't do. Maybe we should all stock up on aspirin before FDA declares aspirin to be an "experimental drug" (as it did with pyridoxamine) and pulls it off the shelves.
The dose used was low (100mg), so it may not even need extra vitamin K to control bleeding, but given the studies showing vitamin K raises testosterone synthesis/levels I think the combination may even more effective. The only drawback of the aspirin therapy was that it has to be taken for 6 weeks. However, given the links between Viagra-type drugs and melanoma (and other deadly cancers), and the fact that aspirin actually seems to treat the condition rather than temporarily improve the symptoms (like Viagra does) - I think this becomes a nobrainer.

Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study
Aspirin Found Effective for Erectile Dysfunction
"...In a prospective randomized double-blind placebo-controlled study, Zeki Bayraktar, MD, and Selami Albayrak, MD, of Istanbul Medipol University in Turkey, found that therapy with 100 mg/day of aspirin for 6 weeks was associated with significant improvement in erectile function compared with placebo among men with VED and a high MPV."

"... At baseline, the proportions of patients who answered yes to SEP2 and SEP3 were similar in both study arms: 51.6% and 31.6%, respectively, for the aspirin group and 50% and 31.2% for the placebo group. At the end of treatment, the proportions answering yes to SEP2 and SEP3 were significantly higher in the aspirin than placebo group (88.3% and 78.3% vs 59.3% and 43.5%). “Aspirin is an effective and safe therapeutic option for patients with VED, especially for patients with a high MPV,” the authors concluded."
 

Lee Simeon

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I am starting to wonder if there is anything aspirin can't do. Maybe we should all stock up on aspirin before FDA declares aspirin to be an "experimental drug" (as it did with pyridoxamine) and pulls it off the shelves.
The dose used was low (100mg), so it may not even need extra vitamin K to control bleeding, but given the studies showing vitamin K raises testosterone synthesis/levels I think the combination may even more effective. The only drawback of the aspirin therapy was that it has to be taken for 6 weeks. However, given the links between Viagra-type drugs and melanoma (and other deadly cancers), and the fact that aspirin actually seems to treat the condition rather than temporarily improve the symptoms (like Viagra does) - I think this becomes a nobrainer.

Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study
Aspirin Found Effective for Erectile Dysfunction
"...In a prospective randomized double-blind placebo-controlled study, Zeki Bayraktar, MD, and Selami Albayrak, MD, of Istanbul Medipol University in Turkey, found that therapy with 100 mg/day of aspirin for 6 weeks was associated with significant improvement in erectile function compared with placebo among men with VED and a high MPV."

"... At baseline, the proportions of patients who answered yes to SEP2 and SEP3 were similar in both study arms: 51.6% and 31.6%, respectively, for the aspirin group and 50% and 31.2% for the placebo group. At the end of treatment, the proportions answering yes to SEP2 and SEP3 were significantly higher in the aspirin than placebo group (88.3% and 78.3% vs 59.3% and 43.5%). “Aspirin is an effective and safe therapeutic option for patients with VED, especially for patients with a high MPV,” the authors concluded."
Do you think Aspirin is suitable at 18 , or should one wait a couple of years, in consideration of Reyes?
 

Serotoninja

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I am starting to wonder if there is anything aspirin can't do. Maybe we should all stock up on aspirin before FDA declares aspirin to be an "experimental drug" (as it did with pyridoxamine) and pulls it off the shelves.
The dose used was low (100mg), so it may not even need extra vitamin K to control bleeding, but given the studies showing vitamin K raises testosterone synthesis/levels I think the combination may even more effective. The only drawback of the aspirin therapy was that it has to be taken for 6 weeks. However, given the links between Viagra-type drugs and melanoma (and other deadly cancers), and the fact that aspirin actually seems to treat the condition rather than temporarily improve the symptoms (like Viagra does) - I think this becomes a nobrainer.

Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo-controlled study
Aspirin Found Effective for Erectile Dysfunction
"...In a prospective randomized double-blind placebo-controlled study, Zeki Bayraktar, MD, and Selami Albayrak, MD, of Istanbul Medipol University in Turkey, found that therapy with 100 mg/day of aspirin for 6 weeks was associated with significant improvement in erectile function compared with placebo among men with VED and a high MPV."

"... At baseline, the proportions of patients who answered yes to SEP2 and SEP3 were similar in both study arms: 51.6% and 31.6%, respectively, for the aspirin group and 50% and 31.2% for the placebo group. At the end of treatment, the proportions answering yes to SEP2 and SEP3 were significantly higher in the aspirin than placebo group (88.3% and 78.3% vs 59.3% and 43.5%). “Aspirin is an effective and safe therapeutic option for patients with VED, especially for patients with a high MPV,” the authors concluded."

Thanks @haidut
Why do you think aspirin has to be taken for 6 weeks? Estrogen excretion from tissues? I hope it's not from increased NO
 
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haidut

haidut

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Do you think Aspirin is suitable at 18 , or should one wait a couple of years, in consideration of Reyes?

I don't think the link between Reyes and aspirin is legit. It is actually much more common with acetaminophen (Tylenol). To this day there has been no proven case of aspirin causing Reyes, only association studies.
So, it should be ok for 18yo but I would ask a doctor just in case.
 
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haidut

haidut

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Thanks @haidut
Why do you think aspirin has to be taken for 6 weeks? Estrogen excretion from tissues? I hope it's not from increased NO

Well, as the studies says, aspirin improves the blood vessel health so that takes time. Speaking of which, Viagra and related drugs have been shown to damage blood vessels and this is why the ads say it may not be suitable for people with established CVD or at high risk for it.
 

Wagner83

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I have an on and off varicocele and when I took aspirin for a few days I felt a blood vessel being "cleared"/"unstuck" inside the pelvic floor. I didn't use it for long enough though. Vitamin c should be nice too.
 
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Braveheart

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I've been on the fence about this for a long since googling "erectile dysfunction and aspirin"
 

Aleeri

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So have anybody here actually experienced improvements in erectile function from using Aspirin?

If used at low dosage 100mg Aspirin per day, would it still present possible risks of bleeding if combined with 500 IU Vitamin E daily? I also take Vitamin K2 (MenaQ7) at 200mg per day.

Also a side question after reading the study above, is MPV not normally tested on CBC blood tests? On my tests I can only see MCV, MCH, platelet count etc, there is no MPV?
 

aguilaroja

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...I also take Vitamin K2 (MenaQ7) at 200mg per day....

As clarification, probably the MK-7 daily dose you are using is 200 micrograms (mcg) rather than 200 milligrams (mg). 200 milligrams of MK-7 would be prohibitively expensive and AFAIK that range has never been tested. BTW, 200 milligram intake of MK-7 would be roughly approximated by eating 2 KILOGRAMS of natto.:):

@haidut has threads describing rationale for use of MK-4 (menaquinone 4) more than MK-7 (menaquinone 7).
 

Aleeri

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As clarification, probably the MK-7 daily dose you are using is 200 micrograms (mcg) rather than 200 milligrams (mg). 200 milligrams of MK-7 would be prohibitively expensive and AFAIK that range has never been tested. BTW, 200 milligram intake of MK-7 would be roughly approximated by eating 2 KILOGRAMS of natto.:):

@haidut has threads describing rationale for use of MK-4 (menaquinone 4) more than MK-7 (menaquinone 7).

Haha yes thanks for the correction, I meant mcg of course. I am trying to follow the 180mcg dosing I saw in one of the longterm studies on MK-7.

Well, I like the idea of MenaQ7 being naturally derived and not so crazy dosed as synthetic Vitamin K supplements. Similar to what I've seen in the studies on Vitamin E derived from Palm Fruit, the amounts are much lower yet very effective. There is some kind of plant intelligence going on there that seems to be lost once you start to isolate and go all reductionist on it.

I am sure there is a good rationale for it with MK-4 but I would be careful with what I consider consuming long term if it's not in natural amounts from foods.

I also have a bottle of this: https://www.amazon.com/Life-Extension-Vitamins-Sea-Iodine-Capsules/dp/B004BD6OAM?th=1 - But the levels of iodine are too high. When I finish my MenaQ7 thought I will try it and see if I notice a difference.
 

theLaw

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So have anybody here actually experienced improvements in erectile function from using Aspirin?

I can safety say that Aspirin at low doses (under 300mg daily) did nothing significant for my ED over several months.

Pansterone, Vitamin K, Beef Liver, and Progestene all helped (very quickly).
 

Frankdee20

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I can safety say that Aspirin at low doses (under 300mg daily) did nothing significant for my ED over several months.

Pansterone, Vitamin K, Beef Liver, and Progestene all helped (very quickly).

I am inclined to agree, Aspirin lowers NO, and I cannot say I noticed improvement in EQ. If anything, it may have decreased that quality.
 

jzeno

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Wow.. Thank you very much for sharing

What can't aspirin benefit?
 

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