Pre-natal Viagra Use Causes Offspring Hypertension And Maternal Diabesity

haidut

Member
Joined
Mar 18, 2013
Messages
17,533
Location
USA / Europe
The study looks weird at first glance - why would pregnant women take Viagra? After all, it is a drug initially developed for treating hypertension and erectile dysfunction (ED) in men. Well, the same misguided idea of using nitric oxide (NO) promoting drugs like Viagra to induce vasodilation has now been applied to the field of gynecology. Namely, drugs like Viagra are being tested on women who experience the so-called foetal growth restriction (FGR) - i.e. their babies do not grow sufficiently in the womb and often end up born prematurely, stillborn, or spontaneously aborted. The very nature of the condition has the signs of insufficient progesterone written all over it. However, mainstream doctors in their infinite wisdom have decided that inducing vasodilation with drugs like Viagra is a "better" approach. Well, now a new study casts strong doubt on this approach and in fact undermines the core claim about Viagra usage in adults - i.e. that it would lower blood pressure. As the study aptly described, giving pregnant women Viagra is not only ineffective for reversing FGR but results in lifelong hypertension for the babies after birth. What's worse, in some cases it led to the babies developing so-called pulmonary arterial hypertension (PAH), which is invariably lethal, often while still in the womb. And if that was not bad enough, the mothers who got Viagra treatment started to exhibit the initial signs of diabetes by the end of the experiment. In light of the findings of this study and the other studies it cites, I am not sure under what rationale does the FDA still allow the prescription/sales of this poison to continue...

Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific Igf2 knockout mouse model of FGR. - PubMed - NCBI
Long term risks cast further doubt on the use of Viagra for foetal therapy

"..The drug, commonly used to treat erectile dysfunction, as it enhances blood flow – has been undergoing trials as a potential treatment for FGR. However, in a recent study in mice, Viagra showed no improvement in foetal growth but did result in high blood pressure in the pups as they reached maturity. Babies with Foetal Growth Restriction (FGR) are at increased risk of stillbirth and are more likely to suffer from developmental problems and other conditions such as heart disease and diabetes in adulthood."

"...An international clinical trial of Viagra on severe cases of human FGR called STRIDER, and carried out at the same time as the Manchester study, also found the drug had no significant benefit on foetal growth or prolongation of pregnancy. The Dutch arm of the STRIDER trial was halted after 11 babies of mothers using the medication died from lung complications, though this did not happen to babies in the New Zealand-Australia or the UK-Ireland trials. In the Manchester study, over 90% of mice whose mothers were given Viagra during their pregnancy experienced a significant increase in their blood pressure. This increase was in the range of values equivalent to those used to diagnose high blood pressure in humans. The effect was similar in both wild type (normally grown) and growth restricted mice and was consistent in both females and males. Female mice also experienced a modest increased weight gain after birth and a minor reduction in glucose tolerance after 8 weeks. The study was carried out by former PhD student Dr Lewis Renshall. He said ”This, and other studies have shown Sildenafil – otherwise known as Viagra – may not be a suitable treatment for FGR unless life-saving benefits can be demonstrated.”
 

schultz

Member
Joined
Jul 29, 2014
Messages
2,557
It seems like it would exacerbate pre-eclampsia, where the blood pressure is increased to compensate for the reduced blood volume. Nitric oxide, by dilating the circulatory system, seems to also increase the blood pressure. Seems like a disaster if you have pre-eclampsia and then take nitric oxide on top of that...
 
Similar threads
Thread starter Title Forum Replies Date
haidut Stress (cortisol) causes pre-term birth by blocking progesterone Scientific Studies 0
M Low carb high fat (pre T3) VS high carb low fat (taking 3 drops of tyronene upon waking) Logs 7
haidut Pre-existing COVID-19 Immunity In 20%-50% Of People - Better Than Vaccines? Scientific Studies 19
Hans The Best Pre-workout Carb Sources Articles & Scientific Studies 47
Drareg Covid-19: Do Many People Have Pre-existing Immunity? Articles & Scientific Studies 0
Adnada Pre Pregnancy Testing, Yes Or No? Ask For Help or Advice 3
S Pre-Conflict Supplements Heart Rate 5
Twohandsondeck Cocoa Or Pre-treated Cacao For Benefit? Diet, Recipes 4
F Is This Pre-workout Stack Any Good? Ask For Help or Advice 3
haidut Aspirin Now Officially Recommended For Pre-eclampsia, Pre-term Birth, And Birth Defects Prevention Scientific Studies 2
F Pre-workout Stack? Ask For Help or Advice 18
A How To Alter 5-HT2C Receptors (pre-MRNA)? Ask For Help or Advice 1
SuperStressed Pre And Post Tyromix Labs Blood Work, Labs 11
charlie New York Area Fire Commissioners Demand New 9/11 Investigation - “pre-planted Explosives" Breaking News 16
healthnatura True K2 Back In Stock And Available For Pre-order! Health Natura 1
Amazigh Pre-Menstrual Breast Pain And High Prolactin Scientific Studies 0
M Pre Cancerous Oral Lesion, Need Help Supplements 4
T My Sister Was Diagnosed With Pre-stage Uterine Cancer Ask For Help or Advice 16
cyclops Pre-workout Supplement? Supplements, Pharmaceutical Drugs 4
Dan Wich Carbon Dioxide, Pre-Mature Aging & Hair Loss Podcast Episode Danny Roddy 0
haidut More Than One Third Of Americans Have Diabetes Or Pre-diabetes Scientific Studies 5
haidut Aspirin Can Treat Pre-eclampsia Scientific Studies 2
J "Pre Workout" Health 20
haidut Vitamin B3 (niacinamide) Can Treat Pre-eclampsia Scientific Studies 6
B Pre-diabetic Symptoms Since Increasing Caloric Intake Ask For Help or Advice 24
Drareg Pre-diabetes And Serum Sex Steroid Hormones Among US Men Scientific Studies 2
haidut Blocking Endotoxin (TLR4) Can Prevent Pre-term Birth Scientific Studies 5
Q Low Dose Oxytocin Antagonists Pre-bed For Receptor Upregulation Supplements, Pharmaceutical Drugs 14
TheHound Pre Workout Supplement Exercise 12
Makrosky Pre-cooked Rice. Is It A Safe Source Of Carbs ? Additives, Cookware, Eating Out, Spices 0
Y Please Help - Need An Alternative Pre-bed Snack Diet 21
M Pre Diabetic So Confused! Blood Work, Labs 53
haidut Pre-registration Of Clinical Trials For New Drugs Causes Them To Stop Working Scientific Studies 4
Westside PUFAs Best Video I've Seen Debunking The Inuit/Esikmo High Fat Eaters, And Mummmies Had Heart Disease Pre- Articles & Scientific Studies 34
Velve921 Fruit instead of ice cream for pre bedtime snack Diet 12
A High Fasting Blood Sugar Levels - "pre-diabetes" Levels Health 32
F Fruit intake for pre-diabetics Diet 2
P Coming From Low-Carb. Pre-Diabetic. Blood Sugar Regulation Blood Sugar 10
O Pre-made bone broth? Broth, Stocks 5
Lokzo Viagra Increases Oxytocin? Scientific Studies 0
Hans Want Great Boners Without Viagra? Try This Stack Out For Size (pun Intended) Articles & Scientific Studies 37
J Transdermal Viagra/sildenafil? Ask For Help or Advice 5
Inaut Danny Roddy - #16: Keto Diet, DHT, Viagra, EMF, Iatrogenesis, Medical Fraud, And Food Additives Danny Roddy 0
P Vitamin E + Sildenafil (Viagra) Helps ED? Male Issues 6
haidut Aspirin As Effective As Viagra For ED, But With Much Fewer Side Effects Scientific Studies 73
haidut Breaking News: Viagra Given To Pregnant Women Is Lethal For The Babies Scientific Studies 4
Herbie Doctors Giving Viagra To Pregnant Women Female Issues 3
Herbie A Quintessential Australian On Viagra Vs Beef The Ray Peat Forum Lounge 1
haidut Viagra May Be Linked To Melanoma Scientific Studies 7

Similar threads

Top