Aspirin As Effective As Viagra For ED, But With Much Fewer Side Effects

haidut

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Yet another blockbuster drug may turn out to be nothing more than a well-marketed gimmick, which while not entirely a scam can be replaced with cheaper, safer alternatives that also have much lower potential for side effects. The drug in question is Viagra, and the humble, just-as-effective substitute is aspirin. A group of doctors out of Turkey has been conducting studies comparing the effects of aspirin on sexual performance in men diagnosed with erectile dysfunction (ED). The experiments go back at least a decade but up until 2018 they were done primarily on animals. However, the last two studies coming out of that group are with humans and the results are quite impressive, especially considering that the aspirin dose was just 100mg daily and the treatment lasted for only 6 weeks. An additional aspect that the popular press articles do not discuss is the potential for aspirin to actually be a so-called "disease modifying therapy". ED is known to be caused by cardiovascular disease (CVD). While Viagra has never been shown to improve the pathology of CVD and no such claims have ever been made about that drug, aspirin HAS been shown to have a long term beneficial effect on CVD. As such, the benefits of aspirin may actually be much longer-lasting and may even be (dare I say) "curative". In other words, after those 6 weeks of aspirin therapy the improvements in erection and sexual function may very well be persistent compared to the people taking Viagra. And as the study found, even if one has to use Viagra, taking aspirin with it significantly lowers the risk of side effects from that drug. Not bad for a tiny pill with more than 3 thousand years of human medical history, and dirt-cheap compared to Viagra.

Antiplatelet (aspirin) therapy as a new option in the treatment of vasculogenic erectile dysfunction: a prospective randomized double-blind placebo... - PubMed - NCBI
Efficacy and safety of combination of tadalafil and aspirin versus tadalafil or aspirin alone in patients with vascular erectile dysfunction: a com... - PubMed - NCBI

"...RESULTS: The changes in IIEF-EF scores after treatment were 7.2 ± 4.4, 7.3 ± 4.3, 7.5 ± 4.4, and 2.0 ± 4.6 for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.0204), respectively. The change in SEP-2 ratios after treatment were 36.6%, 36.9%, 41.7%, and 9.4% for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.2925), respectively. The change in SEP-3 ratios after treatment was 46.6%, 49.2%, 53.7%, and 12.5% for group 1 (p < 0.0001), group 2 (p < 0.0001), group 3 (p < 0.0001), and group 4 (p = 0.1456), respectively. In group 2 [tadalafil], both the number of patients who reported side effects (p < 0.0001) and stopped using the drug due to side effects (p < 0.05) were significantly higher than the control and others groups. CONCLUSIONS: Successful results were obtained by tadalafil and aspirin monotherapy and tadalafil + aspirin combination therapy in patients with VED. However, the least side effect was observed in the tadalafil + aspirin group. Aspirin can be used alone in the treatment of patients with VED, or combined with tadalafil to reduce side effects and increase success."

Could you improve your love life with an aspirin?

"...DAILY aspirin is as effective as Viagra-type drugs for impotence, according to a study. Doctors at Istanbul Medipol University in Turkey divided 336 men with erectile dysfunction into four groups and gave them either aspirin, tadalafil (a Viagra-like drug), tadalafil plus aspirin, or a placebo, according to the study published in International Urology and Nephrology. Taken separately, both drugs increased sexual activity by more than a third, and together, also removed headaches associated with tadalafil. Researchers say aspirin ‘thins' the blood, so more can flow into the genital area, and may help the 70 per cent of men whose impotence has a vascular cause."
 

Frankdee20

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A bit confused, too much Aspirin can mess up my erections sometimes. I have even seen it mentioned on the forum that it lowers Histamine, and can mess up Libido as well.
 

redsun

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A bit confused, too much Aspirin can mess up my erections sometimes. I have even seen it mentioned on the forum that it lowers Histamine, and can mess up Libido as well.

It was 100mg only daily in the study. I dont think there will be significant antihistamine effects at that dose that will lessen libido(it also depends on your own histamine levels). As stated in the OP, the blood thinning, better blood flow would outweigh its miniscule antihistamine effects(at that low dose).
 

schultz

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Is there anything aspirin doesn't do? Considering that aspirin gets a lot of its benefits from opposing PUFA, it really should be obvious to people (mainstream) that PUFA is a significant problem. But then again, the mainstream view is that aspirin is dangerous...
 

haidut

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It was 100mg only daily in the study. I dont think there will be significant antihistamine effects at that dose that will lessen libido(it also depends on your own histamine levels). As stated in the OP, the blood thinning, better blood flow would outweigh its miniscule antihistamine effects(at that low dose).

I think its effects on lowering serotonin may also be involved. Lower serotonin means better libido, and poor libido has been shown to be behind 70%+ of ED cases. Hard (pun intended) to get hard when there is no desire.
Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. - PubMed - NCBI
 

redsun

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I think its effects on lowering serotonin may also be involved. Lower serotonin means better libido, and poor libido has been shown to be behind 70%+ of ED cases. Hard (pun intended) to get hard when there is no desire.
Aspirin attenuates pulmonary arterial hypertension in rats by reducing plasma 5-hydroxytryptamine levels. - PubMed - NCBI

I assumed that it would have an anti-serotonin effect, just didnt know whether it would be significant enough at low dose. I supposed the anti-serotonin effect would also compound up to a point over the 6 weeks it was done of course, but I don't know whether there is such a thing as compounding anti-serotonin effects from the same amount of aspirin daily. I would imagine there would be seeing as it should improve glucose metabolism somewhat despite the lower dose, and better glucose metabolism is always beneficial to hormones and therefore likely beneficial to libido in that way as well.
 

haidut

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I assumed that it would have an anti-serotonin effect, just didnt know whether it would be significant enough at low dose. I supposed the anti-serotonin effect would also compound up to a point over the 6 weeks it was done of course, but I don't know whether there is such a thing as compounding anti-serotonin effects from the same amount of aspirin daily. I would imagine there would be seeing as it should improve glucose metabolism somewhat despite the lower dose, and better glucose metabolism is always beneficial to hormones and therefore likely beneficial to libido in that way as well.

The aspirin doses used in that study were tiny. There were 4 groups and each one of them used the HED of 0.15mg/kg, 0.3mg/kg, 0.45mg/kg and 0.6mg/kg daily. So, even the higher dose group could be mimicked by a single baby aspirin (80mg-100mg) daily daily.
So, easily achievable and great news for aspirin all around.
 

tankasnowgod

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Awesome. From personal experience, I noticed shortly after I started supplementing K2 and Magnesium that morning erections became a daily occurrence. This had never happened to me before, even in my teens. This trend has continued for as long as I've been supplementing. I suspect that anything that improves blood flow will be beneficial in this area, I've heard reports that Inclined Bed Therapy does the same thing. But clearly, better to stick with the safer substances than mess with dangerous ones like Viagra.
 
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When I started to use 1-1.5 grams of aspirin daily for sleep issues I noticed that it kills erection. It took me about a year to overcome this issue and get the opposite effect. Now I actually feel erection improvements with aspirin. Especially after workouts, troubles to maintain erection after gym are gone with aspirin. I guess it is FFA blocking effect of aspirin and elevated FFA after training.
 

jacob

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When I started to use 1-1.5 grams of aspirin daily for sleep issues I noticed that it kills erection. It took me about a year to overcome this issue and get the opposite effect. Now I actually feel erection improvements with aspirin. Especially after workouts, troubles to maintain erection after gym are gone with aspirin. I guess it is FFA blocking effect of aspirin and elevated FFA after training.

What dose? How often?
 

Frankdee20

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haidut

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Does lowering serotonin make premature ejaculation worse ? I notice this with Aspirin sometimes.

Don't know really, but antiserotonin cyproheptadine which is used to recover from SSRI usage is not known to cause premature ejaculation so I'd not expect aspirin to cause it either. I think Peat mentioned vitamin B6 in a recent interview as treatment for PE.
 

Frankdee20

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Don't know really, but antiserotonin cyproheptadine which is used to recover from SSRI usage is not known to cause premature ejaculation so I'd not expect aspirin to cause it either. I think Peat mentioned vitamin B6 in a recent interview as treatment for PE.

Thanks
 

Coderr

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I use 300 mg at night. Is it too much for an erection? Shall I reduce it to 100 mg?
 

stevrd

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Aspirin has only helped my libido and erections. It has also helped my skin as well. I literally tried everything to combat my androgen-driven acne and noticed that after a week of taking 325mg every night my skin cleared dramatically. Now I have been taking 325mg aspirin for about 2 months and feel great! Taking 1mg of K2 per day as well, but was already taking that for about 6 months prior to taking aspirin, so it's not due to that.
 

stevrd

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Does lowering serotonin make premature ejaculation worse ? I notice this with Aspirin sometimes.

Aspirin increases sensitivity for me as well, but in a good way. Not premature ejaculation, as I'm able to control it. My issue for the longest time was delayed ejaculation during intercourse. It became exhausting just to reach climax. Many people think this is a good thing, but after a while even women complain of it because most (normal) women have a limit to how long they can stand. Aspirin helps a great deal in this regard.
 

ilhanxx

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I used all mg version (baby, aspirin, coraspin etc.), baby aspirin give a good affect for boner. I saw this study before. thanks.
 

lampofred

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Does lowering serotonin make premature ejaculation worse ? I notice this with Aspirin sometimes.

I think PE is due to excess adrenaline. Increasing serotonin will lower adrenaline but not in healthy way, it's just making you more sluggish. The real solution would be to increase GABA via better thyroid, red light, salt, etc.
 

stevrd

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@haidut have you ever seen research to show aspirin decreases prolactin? Do you know a mechanism behind it? My refractory period has decreased significantly since I began taking daily, almost to the point of how I was when I was 16. I literally am ready to go again a minute after climax. Thx
 
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