Thank you. Our relationship is close. I prefer for her to find these things out for herself as it's much more powerful in my experience. She is already thinking along these lines. She's honest with herself and a greater seeker of truth. A hobby is a great idea and the obvious one is a pet. I'm going to see about that one. It's great to have this feedback, thank you.
P.S. Thank you for the clips, very useful
She did one within the year, all fine, TSH not out of range. No surprises there, but still I am sure she's hypo, but I'll never get a doctor to prescribe if it's in range and I won't get anything ordered online past customs here.
That's great thank you, I know she's wanting dopaminergic effects, like me. Pregnenolone+theanine+magnesium totally works for me, but not enough in her case.
Thanks for those suggestions, I will follow up. I appreciate the help.
"This study discovered that vitamin D is another potent dopamine agonist, and that its dopaminergic activity contributes to its effects on reducing diet-induced obesity and drug addiction behaviors. The study reminds me of another one, which found that vitamin D reduced peripheral serotonin synthesis."-haidut
Vitamin D Is Dopaminergic And Decreases Obesity And Addiction Behaviors
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"In theory, anything that reduces prolactin will likely also reduce estrogen and vice versa. So, since vitamin A is anti-estrogenic I wondered if there is evidence that vitamin A will lower prolactin and/or increase dopamine. Below is some evidence that vitamin A is indeed dopaminergic and lowers prolactin. The human dose was about 100,000 IU per day or pre-formed all-trans retinoic acid.
Given the human study showing significant fall in prolactin from 300mg vitamin E daily, this likely makes the vitamin A + vitamin E combo a viable option for people wanting to reduce prolactin / estrogen."
Vitamin A is dopaminergic and reduces prolactin in humans
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"The study was really on alcohol consumption what affects it. It has been known since the 1960s that people drink more when under stress but to this day mainstream medicine denies that there is a causative link between stress and substance abuse. I posted a few studies showing that "addicts" have higher levels of cortisol and that lowering cortisol or opposing its effects usually terminates the "addictive" behavior."
Stress Leads To Lower Dopamine And More Drinking
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"The so-called "glucocorticoid resistance" is thought be behind a number of degenerative conditions including diabetes, depression, schizophrenia, chronic inflammation, autoimmune conditions, etc. The condition, similar to insulin resistance, is characterized by elevated serum cortisol levels and low suppression by synthetic glucocorticoids like dexamethasone. Agents that restore the sensitivity of the glucocorticoid receptor lead to decrease of serum cortisol levels, and are thought to be one of the most promising therapeutic agents for chronic disease.
The study below found that vitamin D is one such chemical, and confirmed its effects in humans."
Vitamin D Restores Sensitivity To Cortisol
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Also to back up what others like @alywest said sufficient B-vitamin nutrition can be helpful. Its also been pointed out that it may not be a good idea to use these in isolation (ex; just vitamin b1) so probably good to take a complex like Idealabs 'Energin' for example.
"I have posted a number of studies over the last year showing that vitamin B6 acts acts as an anti-adrenalin and anti-glucocorticoid. As these two substances are obviously elevated in conditions of stress, one might conjecture that controlling them with vitamin B6 would be desirable."-haidut
Vitamin B6 As Effective, General Anti-stress Therapy
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I know you wrote about how you're looking for something dopaminergic, but if inadequate protein isn't consumed the body won't be able to produce sufficient dopamine no matter what hormone, supplement, or drug is taken. Vegans typically have a very difficult time getting sufficient protein, and even then sufficient amounts of the necessary amino acids for good dopamine synthesis. Maybe @haidut can add more to this as I know he's discussed it before
"Peat has written about this, but I will reiterate. Anything less than 1g/kg b.w. of protein per day will create a protein deficiency and will put you in a catabolic state and will also strain the liver and brain with all the ammonia from muscle breakdown, with ammonia buildup being a classic cause of general fatigue.
Also, without adequate protein you will have no dopamine and this alone will make you feel like crap. Finally, low protein intake means no conversion of T4 into T3 by the liver."- Haidut
"A simple protein deficiency has many surprising effects. It lowers body temperature, and suppresses the thyroid, but it increases inflammation and the tendency of blood to clot. Since the brain and heart and lungs require a continuous supply of essential amino acids if they are to continue functioning, in the absence of dietary protein, cortisol must be produced continuously to mobilize amino acids from the expendable tissues, which are mainly the skeletal muscles. These muscles have a high concentration of tryptophan and cysteine, which suppress the thyroid. Cysteine is excitoxic, and tryptophan is the precursor for serotonin. Presumably, their presence in, and stress-induced release from, the muscles is one of the mechanisms that reduce metabolic activity during certain types of stress."-Ray Peat
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Blue-Blocking Level 1
Don’t look at any electronic screens unless you have apps installed to dim the blue light, such as
f.lux on Mac,
f.lux beta for Windows, Nightshift for iPhone (part of the displays and brightness settings), or Twilight on Android (I don’t own an Android but this was recommended to me).
For ambient lighting, use the dimmest lights you have that won’t cause eye strain.
Blue-Blocking Level 2
Although level 1 might be sufficient for some people, for many including myself, it isn’t. Level 2 involves much more complete blue-blocking.
Here’s what you need:
- Several specially designed low-blue amber-colored light bulbs, such as these from lowbluelights.com. Consider their night light and flash light as well.
- A pair of blue-blocking glasses. I recommend Swannies on the basis that they are just as effective as the glasses that make me look like a robotic ant and yet are rather stylish. The same blue-blocking apps as in level 1: f.lux on Mac, f.lux beta for Windows, Nightshift for iPhone or Twilight on Android.
- Chris Masterjohn Phd
Better Sleep
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"First, it adds to the evidence that bipolar disorder is probably environmental in origin, possibly linked to blue light pollution. Second, it adds to the evidence for a link between high cortisol / serotonin and bipolar disorder as blue light strongly stimulates cortisol and serotonin release. Third, it suggests that for many people treating this condition officially labelled as "incurable" may be as simple as wearing orange-tinted glasses at night or sleeping in a room with orange/amber light filters attached to the window glass."
Blocking Blue Light Can Cure Bipolar Disorder