The Importance And Safety Of High-Dose Vitamin D3

[Mito]

 

[Progesterone]

Cliff notes pls?

 

[baccheion]

Cliff notes pls?

Take 30,000 IU/day (adding magnesium and 100 mcg MK-7 per 10,000 IU) as the optimal dose. Go over 40,000 IU (for certain health conditions) only with doctor supervision.

Seems similar to the 300-500 IU/kg/day number..

 

[milkboi]

Take 30,000 IU/day (adding magnesium and 100 mcg MK-7 per 10,000 IU) as the optimal dose. Go over 50,000 IU with doctor supervision (mainly only needed for certain health conditions).

Seems similar to the 300-500 IU/kg/day number..

Sorry, will watch the vid later, but for what conditions could this be helpful?

 

[S-VV]

Careful not to calcify your arteries.

Severe Hypercalcemia Following Vitamin D Supplementation in a Patient With Multiple Sclerosis

Also, there is a limit to the capacity of K2 to carboxylate glutamate residues in blood proteins. The extra negative charge given by the carboxyl group enables the amino acid to coordinate a Ca2+ ion. Since there are a finite number of proteins in the blood, there is a hard cap on the amount of calcium that can be chelated before it complexes with Pyrophosphate and deposits in the endothelium.

 

[baccheion]

Sorry, will watch the vid later, but for what conditions could this be helpful?

Saying 30,000 IU is just the optimal dose in general. Mention of autoimmune conditions treated with doses over 50,000 IU.

There was one book (Optimal Dose) about using 30,000 IU to treat pain.

 

[Tristan Loscha]

Careful not to calcify your arteries.

Severe Hypercalcemia Following Vitamin D Supplementation in a Patient With Multiple Sclerosis

Also, there is a limit to the capacity of K2 to carboxylate glutamate residues in blood proteins. The extra negative charge given by the carboxyl group enables the amino acid to coordinate a Ca2+ ion. Since there are a finite number of proteins in the blood, there is a hard cap on the amount of calcium that can be chelated before it complexes with Pyrophosphate and deposits in the endothelium.

True in regard to K2.
In the study you are linking,the investigators are not so sure if
it came from D intoxication or transient ischemic attack or seizure.
They just gave her rehydration (lol) and that solved this little crisis.
But still,the patient had very high D and high Calcium.
i would not go over 800mg/d Ca if going above 20000IU/D3/d.

 

[baccheion]

True in regard to K2.
In the study you are linking,the investigators are not so sure if
it came from D intoxication or transient ischemic attack or seizure.
They just gave her rehydration (lol) and that solved this little crisis.
But still,the patient had very high D and high Calcium.
i would not go over 800mg/d Ca if going above 20000IU/D3/d.

500-600 mg calcium is what's recommended to Coimbra patients. Balance is made up with much higher magnesium, at least 1:1 with phosphorus. 800-1,200 mg/day.

 

[Tristan Loscha]

500-600 mg calcium is what's recommended to Coimbra patients. Balance is made up with much higher magnesium, at least 1:1 with phosphorus. 800-1,200 mg/day.

I was replying to the case in that study,
but for very high dose people like Coimbra-Protocol,500mg-600mg Ca and so forth that you were posting
is much better.

 

[Tristan Loscha]

True in regard to K2.
In the study you are linking,the investigators are not so sure if
it came from D intoxication or transient ischemic attack or seizure.
They just gave her rehydration (lol) and that solved this little crisis.
But still,the patient had very high D and high Calcium.
i would not go over 800mg/d Ca if going above 20000IU/D3/d.

"i would not go over 800mg/d Ca if going above 20000IU/D3/d."



This is a misleading statement from me.
For clarification,

For general-purpose supplementation,i would advise against
going above intakes of 20000IUD3/d per os.For general purpose,
10000IU as maintenance,-20000IU/max with D-serum level not above 80-90ng/ml.
10000IU-20000IU is my reading of the literature for optimal D if you have no sunlight-D as background.

In the standardized models are 3000IU D from UV presupposed.

Up to 90ng/ml (225nmol/l) were found to be achieveable by UV irradiation.
I would recc against going over that amount,except for Loading Dosages,pharmacological Dosing would begin after that,but not before.Calcium labs should be had if going above 10000IU in my
opinion.

A lot of the canonical Calcium recommendation is quite high,and is thought in front of a background of more or less
severe D deficiency.Maybe it needs adjustment downward for correction of corrected D deficiency and parallel enhancement of efficiency of Ca-handling like increased uptake and increased renal reabsorption.

For comparison,iirc,Peat advises 50-60ng/ml,and intake of 5000IU D3.