From:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712358/
"Here, we propose that, in susceptible persons, multiple vaccinations activate the retinoid cascade and trigger apoptotic hepatitis, leading to cholestatic liver dysfunction, in which stored vitamin A compounds (retinyl esters and retinoic acid) enter the circulation in toxic concentrations; this induces endogenous forms of hypervitaminosis A, with the severity of adverse outcomes being directly proportional to the concentration of circulating retinoids. In very low concentrations, vitamin A and its major metabolite retinoic acid contribute to immune function and to the process of immunization, whereas excess vitamin A increases the risk of adverse events, including common “side-effects” as well as chronic adverse outcomes. The increasing rates of allergy, ear infections, and neurodevelopmental disorders (NDDs) in countries with high rates of vaccination could be related to mass vaccination and to its impact on liver function and vitamin A metabolism, collectively representing endogenous manifestations of hypervitaminosis A. "
"The balance of the risks and benefits from the receipt of the recommended vaccination schedule therefore remains uncertain.
In the face of this uncertainty, the first author and colleagues studied vaccinated and unvaccinated homeschooled children, among whom vaccination coverage rates are lower than in the general population [31,32]. The aims were to compare health outcomes and exposures to determine if any association found between vaccination and NDDs remained significant after controlling for other significant factors. The survey targeted homeschooling mothers in the states of Florida, Louisiana, Mississippi, and Oregon. The mothers were asked to complete an anonymous questionnaire on their 6- to 12-year-old biological children regarding pregnancy-related exposures, birth history, vaccinations, physician-diagnosed illnesses, medications, and the use of health services. NDDs were defined as having one or more of the following: A physician diagnosis of autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), or a learning disability. A sample of 666 children was obtained, of which 261 (39%) were unvaccinated. The vaccinated were significantly less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis; they were, however, significantly more likely to have been diagnosed with:
Some of those odds ratios are pretty high, although granted the CIs are wide.
The takeaway to me seems to be to space out or reduce vaccinations, avoid anything with adjuvants, and undertake some liver-supportive measure in combination with keeping Vitamin A intake modest.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712358/
"Here, we propose that, in susceptible persons, multiple vaccinations activate the retinoid cascade and trigger apoptotic hepatitis, leading to cholestatic liver dysfunction, in which stored vitamin A compounds (retinyl esters and retinoic acid) enter the circulation in toxic concentrations; this induces endogenous forms of hypervitaminosis A, with the severity of adverse outcomes being directly proportional to the concentration of circulating retinoids. In very low concentrations, vitamin A and its major metabolite retinoic acid contribute to immune function and to the process of immunization, whereas excess vitamin A increases the risk of adverse events, including common “side-effects” as well as chronic adverse outcomes. The increasing rates of allergy, ear infections, and neurodevelopmental disorders (NDDs) in countries with high rates of vaccination could be related to mass vaccination and to its impact on liver function and vitamin A metabolism, collectively representing endogenous manifestations of hypervitaminosis A. "
"The balance of the risks and benefits from the receipt of the recommended vaccination schedule therefore remains uncertain.
In the face of this uncertainty, the first author and colleagues studied vaccinated and unvaccinated homeschooled children, among whom vaccination coverage rates are lower than in the general population [31,32]. The aims were to compare health outcomes and exposures to determine if any association found between vaccination and NDDs remained significant after controlling for other significant factors. The survey targeted homeschooling mothers in the states of Florida, Louisiana, Mississippi, and Oregon. The mothers were asked to complete an anonymous questionnaire on their 6- to 12-year-old biological children regarding pregnancy-related exposures, birth history, vaccinations, physician-diagnosed illnesses, medications, and the use of health services. NDDs were defined as having one or more of the following: A physician diagnosis of autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), or a learning disability. A sample of 666 children was obtained, of which 261 (39%) were unvaccinated. The vaccinated were significantly less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis; they were, however, significantly more likely to have been diagnosed with:
- Allergic rhinitis (Odds Ratio: 30.1; 95% Confidence Interval: 4.1, 219.3);
- Eczema (OR: 2.9; 95% CI: 1.4, 6.1);
- A middle ear infection (OR: 3.8; 95% CI: 2.1, 6.6);
- Pneumonia (OR: 5.9; 95% CI: 1.8, 19.7);
- An NDD (OR: 3.7; 95% CI: 1.7, 7.9)."
Some of those odds ratios are pretty high, although granted the CIs are wide.
The takeaway to me seems to be to space out or reduce vaccinations, avoid anything with adjuvants, and undertake some liver-supportive measure in combination with keeping Vitamin A intake modest.