Vitamins E, A, C Can Be Bad For Cancer Patients

Discussion in 'Scientific Studies' started by Pompadour, Jan 16, 2020.

  1. Pompadour

    Pompadour Member

    Joined:
    May 11, 2017
    Messages:
    254
    Gender:
    Female
    Location:
    Russia-Deutschland
    This study looks alarming, giving using of vitamins E and other among members of the forum

    https://ascopubs.org/doi/abs/10.1200/JCO.19.01203
    PURPOSE

    Despite reported widespread use of dietary supplements during cancer treatment, few empirical data with regard to their safety or efficacy exist. Because of concerns that some supplements, particularly antioxidants, could reduce the cytotoxicity of chemotherapy, we conducted a prospective study ancillary to a therapeutic trial to evaluate associations between supplement use and breast cancer outcomes.

    METHODS

    Patients with breast cancer randomly assigned to an intergroup metronomic trial of cyclophosphamide, doxorubicin, and paclitaxel were queried on their use of supplements at registration and during treatment (n =1,134). Cox proportional hazards regression adjusting for clinical and lifestyle variables was used. Recurrence and survival were indexed at 6 months after enrollment using a landmark approach.

    RESULTS

    There were indications that use of any antioxidant supplement (vitamins A, C, and E; carotenoids; coenzyme Q10) both before and during treatment was associated with an increased hazard of recurrence (adjusted hazard ratio [adjHR], 1.41; 95% CI, 0.98 to 2.04; P = .06) and, to a lesser extent, death (adjHR, 1.40; 95% CI, 0.90 to 2.18; P = .14). Relationships with individual antioxidants were weaker perhaps because of small numbers. For nonantioxidants, vitamin B12 use both before and during chemotherapy was significantly associated with poorer disease-free survival (adjHR, 1.83; 95% CI, 1.15 to 2.92; P < .01) and overall survival (adjHR, 2.04; 95% CI, 1.22 to 3.40; P < .01). Use of iron during chemotherapy was significantly associated with recurrence (adjHR, 1.79; 95% CI, 1.20 to 2.67; P < .01) as was use both before and during treatment (adjHR, 1.91; 95% CI, 0.98 to 3.70; P = .06). Results were similar for overall survival. Multivitamin use was not associated with survival outcomes.
     
  2. Coderr

    Coderr Member

    Joined:
    Mar 15, 2019
    Messages:
    36
    Gender:
    Male
    What form of vitamin E was this research written? Does that apply to tocotrienols?
     
  3. schultz

    schultz Member

    Joined:
    Jul 29, 2014
    Messages:
    1,946
    So don't take 'antioxidant' supplements whilst also getting irradiated? Noted. I don't plan on ever getting chemotherapy so it looks like I am safe.
     
  4. bzmazu

    bzmazu Member

    Joined:
    Oct 29, 2015
    Messages:
    1,211
    Gender:
    Male
    Location:
    Corozal, Belize
    I have been successful overcoming blood cancer (leukemia) with Artemisinin...it is a pro-oxidant...one of the prerequisites is to not take antioxidants at the same time. While we typically hear about the benefits of anti-oxidants for health, there are certain instances where promoting oxidation can be beneficial. Cancer researchers are looking at compounds that provide a pro-oxidant effect when they encounter cancer cells.
     
  5. Jkbp

    Jkbp Member

    Joined:
    Jun 26, 2016
    Messages:
    11
    Gender:
    Female
    my mother beat lung cancer 3 times and kept it at bay for the better part of 22 years, by taking artemisinin.


     
  6. Vinny

    Vinny Member

    Joined:
    Dec 11, 2018
    Messages:
    813
    Gender:
    Male
    Location:
    Paphos, Cyprus
    Amazing ...
     
  7. charlie

    charlie The Law & Order Admin

    Joined:
    Jan 4, 2012
    Messages:
    11,080
    Gender:
    Male
    Location:
    USA
    Wow!!! Incredible!
     
  8. tankasnowgod

    tankasnowgod Member

    Joined:
    Jan 25, 2014
    Messages:
    2,909
    Gender:
    Male
    You might even be able to take it during irradiation and be fine! Just don't say you take A, C or E on a medical survery. That's really the only thing they tested.
     
  9. Jkbp

    Jkbp Member

    Joined:
    Jun 26, 2016
    Messages:
    11
    Gender:
    Female
    My mom also took MANY antioxidants daily throughout the 22 years, including during treatments. The only vit A she took would have been from a one-a-day multi. I would need to check her list to see if she took extra E. She eventually lost her battle with lung cancer last July, after being cancer free for another 5 years. I’m embarrassed to say it, but she smoked until a few weeks before she died. She and I both know that the artemisinin and antioxidants kept her alive all those extra years. She would take the artemisinin for 6-8 weeks, leading up to her every six month CT scan

     
  10. bzmazu

    bzmazu Member

    Joined:
    Oct 29, 2015
    Messages:
    1,211
    Gender:
    Male
    Location:
    Corozal, Belize
    Artemisinin has an extremely short half life...so yes, antioxidants can be taken ...but away from the Artemisinin dose.
     
  11. sugarbabe

    sugarbabe Member

    Joined:
    Sep 13, 2012
    Messages:
    2,908
    IV Vitamin C is effective not as an antioxidant but because it then becomes an oxidant right?
     
  12. RWilly

    RWilly Member

    Joined:
    Aug 30, 2018
    Messages:
    331
    "could reduce the cytotoxicity of chemotherapy" is the key phrase here.

    Exactly.

    That's what I figure too. I just stay away from doctors. Sometimes I wonder why I'm paying that hefty health insurance bill every month. (I suppose it's because if I fall off a ladder, it'll cost something like $10,000 to get cast, and if I have an overnight hospital stay, I'm probably paying $50K.)
     
  13. Gone Peating

    Gone Peating Member

    Joined:
    Sep 16, 2018
    Messages:
    549
    Gender:
    Male
    I had an uber driver once who told me that breathing pure oxygen is the best treatment for cancer
     
  14. RWilly

    RWilly Member

    Joined:
    Aug 30, 2018
    Messages:
    331
    Glad you have been successful!! Were you doing chemo at the same time? (Wondering what conditions pro-oxidants work best in.)
     
  15. bzmazu

    bzmazu Member

    Joined:
    Oct 29, 2015
    Messages:
    1,211
    Gender:
    Male
    Location:
    Corozal, Belize
    would never do chemo...research it...looks like they work best by themselves..
     
  16. RWilly

    RWilly Member

    Joined:
    Aug 30, 2018
    Messages:
    331
    Good to know. Thanks for sharing your success story.
     
  17. dannibo

    dannibo Member

    Joined:
    Mar 2, 2017
    Messages:
    68
    Gender:
    Male
    If you believe that vitamins interfere with poison chemotherapy that is in fact useless then your mind needs retuned.
     
  18. Vinny

    Vinny Member

    Joined:
    Dec 11, 2018
    Messages:
    813
    Gender:
    Male
    Location:
    Paphos, Cyprus
    She has not said so far, that she believed in it. That's purely your assumption that she had, and your post sounds kinda rude.
     
  19. LucyL

    LucyL Member

    Joined:
    Oct 21, 2013
    Messages:
    418
    These statements are contradictory enough that one should really read the full study before considering any modifications based on it.
     
  20. LucyL

    LucyL Member

    Joined:
    Oct 21, 2013
    Messages:
    418
    haidut posted some old studies recently, some about Vitamin E, and the post contained this quote:
     
Loading...