Fruit And Vegetable Juices Decrease The Risk Of Alzheimer's (Kame Project)

[kiran]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266591/

METHODS

We tested whether consumption of fruit and vegetable juices, containing a high concentration of polyphenols, decreases the risk of incident probable Alzheimer’s disease in the Kame Project cohort, a population-based prospective study of 1836 Japanese Americans in King County, Washington, who were dementia-free at baseline (1992–1994) and were followed through 2001.
RESULTS

After adjustment for potential confounders, the hazard ratio for probable Alzheimer’s disease was 0.24 (95% confidence interval [CI], 0.09–0.61) comparing subjects who drank juices at least 3 times per week with those who drank less often than once per week with a hazard ratio of 0.84 (95% CI, 0.31–2.29) for those drinking juices 1 to 2 times per week (P for trend < .01). This inverse association tended to be more pronounced among those with an apolipoprotein Eε-4 allele and those who were not physically active. Conversely, no association was observed for dietary intake of vitamins E, C, or β- carotene or tea consumption.

The inverse association between fruit and vegetable juices and Alzheimer’s disease appeared in all strata of education, smoking status, tea drinking, regular physical activity, ApoE genotype, and total fat intake. However, the association tended to be stronger among those who were former or current smokers, drank tea less often, were positive for the ApoE ε-4 allele, and were less physically active. Although no statistically significant interactions were found, the tests for interactions by ApoE genotype (P for interaction, .07) and regular physical activity (P for interaction, .06) were of borderline significance.