Advice Or Suggestions Regarding Alzheimer's

BTC

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Hello, long-time follower, first-time poster. I’m just wondering if anybody has any “Peaty” suggestions and/or insights regarding Alzheimer’s (and particularly, slowing its progression). I’m writing this regarding my 85 y/o father, who has been recently diagnosed with Alzheimer’s and while it is still early, he clearly was demonstrating symptoms when I saw him over Christmas, so this isn’t a surprise to me at all.

Overall, he’s been very strict about his health for as long as I remember. He was a Cardiologist, and he always prioritized his health, but he has some beliefs that may be more typical of a doctor who practiced in the 70s and 80s, i.e., low fat (especially saturated), low cholesterol, low salt, never drank or smoked (or other drugs), always exercised (but moderately and/or for fun). We are Iranian, so I’d say his diet is typical of how he grew up, a lot of bread and cheese (feta), a ton of fruit, rice, stews, kabobs (chicken and beef usually), some sugar or candy with his black tea or morning coffee, soups, salads. I’d say the main non-peaty aspects of his diet were (and continue to be) his avoidance of salt, cholesterol, and saturated fat, love of bread (Persian breads though, so I don’t know if they were fortified, adulterated, or made with PUFAs), a belief that cooking oil should be vegetable oil, and while he ate a lot of organ meats, including liver, growing up, it’s pretty much been excluded from his diet in adulthood. He does like muscle meat, but not in very large quantities.

He remains somewhat active by walking a couple of miles ever other day, but he has knee problems that have gotten worse and he’s developed balance issues that have caused him to fall and injure himself. But walking is pretty much the only thing he loves to do that he can still do, so he perseveres.

Also, his doctor is prescribing him Aricept® (donepezil), so I'm not sure what to expect from that.

Certainly, there’s a limit to how much I’m going to be able to get him to deviate from what he believes to be healthy and/or prefers, but my mom cares for him, so I may be able to get some things done with her help.

Basically, I’m wondering if people have some knowledge or insight on some strategies to slow the progression of the disease.

Thank you for your time.
 

Wagner83

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Did you search the forums for that?
I'm pretty sure Haidut posted a study on methylene blue being helpful. Aspirin, , vitamin E and niacinamide (lower endotoxin and free fatty acids) seem to have their place too.
Also Ray did podcasts on dementia that you may be interested in.
 
OP
B

BTC

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I did do some research in the forums (though I wrote the post about 1/2 hour after I received news of the diagnosis from my mother, so not a lot before posting). I saw Haidut's post and thread on blocking PUFA metabolism to reverse Alzheimer's, so I'm working from that now. I didn't think about looking into dementia, which definitely seems like a good idea, especially if Ray has some podcasts about it, so thank you for that.


Did you search the forums for that?
I'm pretty sure Haidut posted a study on methylene blue being helpful. Aspirin, , vitamin E and niacinamide (lower endotoxin and free fatty acids) seem to have their place too.
Also Ray did podcasts on dementia that you may be interested in.
 

paymanz

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I read some articles recently, they say insuline resistance in brain may be responsible for Alzheimer's.

And that insulin resistance in brain mediated by inflammation. So controlling inflammation probably helps.


Things like aspirin,vitamin E like others mentioned above,reducing PUFA, vitamin D,thyroid,progesterone( I think ray recommend this one especially!).

Also make sure he gets enough b vitamins, especially thiamine.

Blocking Inflammation From PUFA Reverses Brain Aging

Asthma drug Singulair may be a cure for Alzheimer's, claims study | Daily Mail Online
 
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raypeatclips

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I see someone has already posted one of the videos on my channel. I have a few clips of Ray talking about alzheimer's, if you want to hear his voice yourself, here is a link to all the videos he has mentioned alzheimers so far.

Ray Peat Clips
 
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Handling day to day challenges needs coping skills. I always suggest the caregivers of such patients to maximize independence and live a meaningful life with diagnosis. My Dad who is an Alzheimer's patient struggle everyday. Accepting changes, creating a coping strategy, tips for daily living, are few must dos for alzheimers patients. My dad who is under the care of an assisted living facilities nevada, prestige care inc. While creating a coping strategy identify and make a list of tasks which are challenging, prioritize them, startegize and find solution that works best for you.
Develop a daily routine, approach one task at a time and don't get stuck, set realistic goals, recognize the triggers that cause you stress, and use your sources of strength. Take advice from others who are living with Alzheimers.
 

Travis

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Alzheimer's is caused by aluminum, but representatives of industry have managed to instill enough doubt that most people remain ambivalent.

Characteristic of Alzheimer's are neurofibrillary tangles. The tau (τ) proteins of the brain are heavily phosphorylated, and aluminum has a high affinity for phosphate.

This causes crosslinking. I made this graphic (yes, I actually looked-up the protein sequence of τ-protein) :
tau protein.png

Here is a graphic that an Alzheimer researcher made, without the phosphate groups:
alzheimer's.png


Unfortunately, the crosslinked tau (τ) proteins (neurofibrillary tangles) are resistant to proteolysis., so a low-aluminum diet along with silica and chelation may be the only treatment. Desferrioxamine is the archetypal aluminum chelator.

There is a sea of evidence for this. Some notable full articles are as follows. I have read a few of these:

The Chemistry of Aluminum and Silicon in Relation to Alzheimer’s Disease
Chronic Aluminum Intake Causes Alzheimer’s Disease: Applying Sir Austin Bradford Hill’s Causality Criteria
Aluminum and Silica in Drinking Water and the Risk of Alzheimer's Disease or Cognitive Decline: Findings From 15-Year Follow-up of the PAQUID Cohort
Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident
Aluminum and Alzheimer’s Disease: After a Century of Controversy, Is there a Plausible Link?
Evidence for Participation of Aluminum in Neurofibrillary Tangle Formation and Growth in Alzheimer’s Disease
Aluminium and Alzheimer's Disease: The Science that Describes the Link
Aluminum in hippocampal neurons from humans with Alzheimer’s disease
Aluminum Modifies the Properties of Alzheimer’s Disease PHFτ Proteins in vivo and in vitro
Interaction of Aluminum with PHFτ in Alzheimer’s Disease Neurofibrillary Degeneration Evidenced by Desferrioxamine-Assisted Chelating Autoclave Method
Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer’s disease


And some analysis of aluminum concentrations in food:

Aluminum, boron, calcium, copper, iron, magnesium, manganese, molybdenum, phosphorus, potassium, sodium, and zinc: concentrations in common western foods and estimated daily intakes by infants; toddlers; and male and female adolescents, adults, and seniors in the United States.
ALUMINIUM IN FOOD
Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese



 

Drareg

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Alzheimer's is caused by aluminum, but representatives of industry have managed to instill enough doubt that most people remain ambivalent.

Characteristic of Alzheimer's are neurofibrillary tangles. The tau (τ) proteins of the brain are heavily phosphorylated, and aluminum has a high affinity for phosphate.

This causes crosslinking. I made this graphic (yes, I actually looked-up the protein sequence of τ-protein) :
View attachment 5388
Here is a graphic that an Alzheimer researcher made, without the phosphate groups:
View attachment 5389

Unfortunately, the crosslinked tau (τ) proteins (neurofibrillary tangles) are resistant to proteolysis., so a low-aluminum diet along with silica and chelation may be the only treatment. Desferrioxamine is the archetypal aluminum chelator.

There is a sea of evidence for this. Some notable full articles are as follows. I have read a few of these:

The Chemistry of Aluminum and Silicon in Relation to Alzheimer’s Disease
Chronic Aluminum Intake Causes Alzheimer’s Disease: Applying Sir Austin Bradford Hill’s Causality Criteria
Aluminum and Silica in Drinking Water and the Risk of Alzheimer's Disease or Cognitive Decline: Findings From 15-Year Follow-up of the PAQUID Cohort
Disturbance of cerebral function in people exposed to drinking water contaminated with aluminium sulphate: retrospective study of the Camelford water incident
Aluminum and Alzheimer’s Disease: After a Century of Controversy, Is there a Plausible Link?
Evidence for Participation of Aluminum in Neurofibrillary Tangle Formation and Growth in Alzheimer’s Disease
Aluminium and Alzheimer's Disease: The Science that Describes the Link
Aluminum in hippocampal neurons from humans with Alzheimer’s disease
Aluminum Modifies the Properties of Alzheimer’s Disease PHFτ Proteins in vivo and in vitro
Interaction of Aluminum with PHFτ in Alzheimer’s Disease Neurofibrillary Degeneration Evidenced by Desferrioxamine-Assisted Chelating Autoclave Method
Demonstration of aluminum in amyloid fibers in the cores of senile plaques in the brains of patients with Alzheimer’s disease


And some analysis of aluminum concentrations in food:

Aluminum, boron, calcium, copper, iron, magnesium, manganese, molybdenum, phosphorus, potassium, sodium, and zinc: concentrations in common western foods and estimated daily intakes by infants; toddlers; and male and female adolescents, adults, and seniors in the United States.
ALUMINIUM IN FOOD
Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese

This is interesting,you could also say they are fabricating aluminium Alzheimers link because other areas of Alzheimer's treatment are failing,as in failing financially for a pharmaceutical point of view,most people don't trust the meds for Alzheimers,word is spreading quickly that the meds are a form of palliative care,anti psychotics and benzodiazepines,the aricept which is an acetylcholinesterase inhibitor ruins people,it gives them twitches and they get the label of Lewy body dementia to cover the malpractice.
The ssri's pick and mix selection for Alzheimer's causes strokes,mini strokes,they also use the levy bodies dementia to cover this.

Psychopathic hospital consultants don't even bother to measure T3,RT3 or any hormones,the are full blown psychopaths,this is not a rant....

We can all help the world by spreading the meme of "all hospital consultants are psychopathic" as much hyperbole as possible,who would take on the task of treating over 150 patients from heart disease to Alzheimers and believe this is feasible,they use terms like "specialist" to inform people feelings of reassurance of helping the unfortunate patient/victim while slowly killing them.
Expect media puff pieces on said consultants to claim the psychopathic badge is not fair or reasonable soon(when their loosing for paid by the hour money for slow murder)

Incidentally the establishment consultants(special people with special brain power) are now saying "palliative care" while pickling your loved one full of anti psychotics because family members woke up the fact they were paying astronomical sums by the hour under the guise and subtle verbal coercion of "curing the patient" while clearly seeing the pills are for managing the patient and easing the burden on the carer.
 

Travis

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The aluminum-Alzheimer's link was first noticed inthe '60s after researchers experimentally produced nuerofibrillary tangles in rabbits with aluminum injections.

To date, the only way to produce the characteristic histological features seen in the Alzheimer's brain is through aluminum.

aluminum.png


They also have about ¹⁄₄ the melatonin levels, and a more calcified pineal gland.

In Alzheimer's, I think aluminum should be considered public enemy #1 and fluoride public enemy #2.

Imbalances between calcium and vitamin D could theoretically hypercalcify the pineal gland leading to low melatonin, but we need those. Aluminum and fluoride and both toxic and serve no useful function in the body.
 

encerent

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The aluminum-Alzheimer's link was first noticed inthe '60s after researchers experimentally produced nuerofibrillary tangles in rabbits with aluminum injections.

To date, the only way to produce the characteristic histological features seen in the Alzheimer's brain is through aluminum.

View attachment 5516

They also have about ¹⁄₄ the melatonin levels, and a more calcified pineal gland.

In Alzheimer's, I think aluminum should be considered public enemy #1 and fluoride public enemy #2.

Imbalances between calcium and vitamin D could theoretically hypercalcify the pineal gland leading to low melatonin, but we need those. Aluminum and fluoride and both toxic and serve no useful function in the body.

How do i reduce aluminum or block it's bad effects?
 

Travis

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We must avoid eating it!

I am reading about melatonin right now and how it is released by the pineal gland into the brain at night. It has antioxidant functions as is also a purported metal-chelating agent:

melatonin2.png


A review of metal-catalyzed molecular damage: protection by melatonin

So the brain does have a natural ability to detox heavy metals at night, given the pineal gland is able to synthesize melatonin. This effect declines with increased pineal calcification.

At night, increased melatonin and low norepinephrine allows a transfer of fluid between the brain and the interstitial brain fluid. This effect has been studies by Lulu Xie: Sleep Drives Metabolite Clearance from the Adult Brain

Most dietary aluminum comes ultimately from double-acting baking powder, a mixture of aluminum phosphate and sodium bicarbonate. At high temperature, this mixture produces carbon dioxide bubbles which raise bread.

A significant amount is also added to processed cheese as a rheological agent: the aluminum disrupts that proteins, lowering the melting point.

So frozen pizza would be the #1 thing to avoid, along with the things in this table: Aluminium content of some foods and food products in the USA, with aluminium food additives

Aluminum is another reason to avoid commercially-baked food. If you like bread, it can be made at home without dangerous amounts of iron and aluminum.

The cheese that has aluminum added appears only to be the bottom-of-the-barrel type: kraft singles and the ***t they put in HotPockets and such. Most respectable cheese has very low amounts of aluminum, as the cow filters-out nearly all of it.
 

David PS

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