Selenium provides potent neuroprotection after cerebral ischemia

[Mauritio]

"Despite progress in reperfusion therapy, functional recovery remains suboptimal in many stroke patients, with oxidative stress, inflammation, dysbiosis, and secondary neurodegeneration constituting the major hurdles to recovery. The essential trace element selenium is emerging as a promising therapeutic agent for stroke. However, although several rodent studies have shown that selenium can protect against cell loss following cerebral ischemia, no study has yet examined whether selenium can enhance long-term functional recovery. Moreover, published studies have typically reported a single mechanism of action underlying selenium-mediated stroke recovery. However, we propose that selenium is more likely to have multifaceted actions. Here, we show that selenomethionine confers a potent neuroprotective effect in a canonical filament-induced transient middle cerebral artery occlusion (tMCAO) mouse model. Post-tMCAO selenium treatment significantly reduces the cerebral infarct volume, oxidative stress, and ferroptosis and enhances post-tMCAO motor performance in the acute phase after stroke. Moreover, analysis of the gut microbiota reveals that acute selenium treatment reverses stroke-induced gut dysbiosis. Longer-term selenium supplementation activates intrinsic neuroprotective mechanisms, prevents secondary neurodegeneration, alleviates systemic inflammation, and diminishes gut microbe-derived circulating trimethylamine N-oxide. These findings demonstrate that selenium treatment even after cerebral ischemia has long-term and multifaceted neuroprotective effects, highlighting its clinical potential."

- Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice - PubMed

 

[Mauritio]

"...by the significantly reduced oxidative stress, downregulated pro-inflammatory cytokines expression, improved integrity of blood-brain barrier, as well as suppressed glial activation and shifted microglial MI/M2 polarization in Se-sup mouse brain. Se intake also reduced neural cell death and significantly improved the cognition in Se-sup mice following LPS challenge."

- Selenium supplementation enhanced the expression of selenoproteins in hippocampus and played a neuroprotective role in LPS-induced neuroinflammation - PubMed

 

[Nokoni]

"Despite progress in reperfusion therapy, functional recovery remains suboptimal in many stroke patients, with oxidative stress, inflammation, dysbiosis, and secondary neurodegeneration constituting the major hurdles to recovery. The essential trace element selenium is emerging as a promising therapeutic agent for stroke. However, although several rodent studies have shown that selenium can protect against cell loss following cerebral ischemia, no study has yet examined whether selenium can enhance long-term functional recovery. Moreover, published studies have typically reported a single mechanism of action underlying selenium-mediated stroke recovery. However, we propose that selenium is more likely to have multifaceted actions. Here, we show that selenomethionine confers a potent neuroprotective effect in a canonical filament-induced transient middle cerebral artery occlusion (tMCAO) mouse model. Post-tMCAO selenium treatment significantly reduces the cerebral infarct volume, oxidative stress, and ferroptosis and enhances post-tMCAO motor performance in the acute phase after stroke. Moreover, analysis of the gut microbiota reveals that acute selenium treatment reverses stroke-induced gut dysbiosis. Longer-term selenium supplementation activates intrinsic neuroprotective mechanisms, prevents secondary neurodegeneration, alleviates systemic inflammation, and diminishes gut microbe-derived circulating trimethylamine N-oxide. These findings demonstrate that selenium treatment even after cerebral ischemia has long-term and multifaceted neuroprotective effects, highlighting its clinical potential."

- Selenium supplementation provides potent neuroprotection following cerebral ischemia in mice - PubMed

Thanks for this and for your post on selenium and mercury. I've got a mouthful of mercury and had a stroke last year, but I do supplement selenium and it's good to learn that it may be helping.

 

[Peatress]

I seem to have a higher than normal requirement for selenium.

 

[Mauritio]

I seem to have a higher than normal requirement for selenium.

How does that manifest itself?

 

[Peatress]

How does that manifest itself?

I noticed when I take it I get immediate relief from calcified tissues (head)

 

[Mauritio]

I noticed when I take it I get immediate relief from calcified tissues (head)

I think that is its anti-oxidant effect

 

[youngsinatra]

I find the restoration of gut microbiota very interesting.
Definitely makes it worth for me to revisit this topic and do some more reading on selenium.

 

[kimbriel]

I seem to have a higher than normal requirement for selenium.

How did you ascertain this? I'd like to learn if I do, too.

 

[kimbriel]

I noticed when I take it I get immediate relief from calcified tissues (head)

Oh, wow- thanks!

 

[Peatress]

I think that is its anti-oxidant effect

It's a calcium channel blocker

 

[Mauritio]

It's a calcium channel blocker

Its an anti-oxidant

 

[Peatress]

Its an anti-oxidant

It's both