Magnesium And Stress

Discussion in 'Magnesium' started by nigma, Jul 7, 2019.

  1. nigma

    nigma Member

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    Magnesium is super important - From my past reading, I know that it is one of the dietary inputs that was found to be correlated to all-cause-mortality. My experience with magnesium oil has been life changing, especially in combination with potassium, it is calming, stress inhibiting, stress proofing, relaxing, warms hands and feet very well. Mg++ and K+ are the dominant intracellular cations when cells are in the resting state, during extended stress (life) we deplete our stores, modern diets are low due in part to left-brain farming practices.

    Found a good resource and thought I'd share:

    Magnesium and stress - Magnesium in the Central Nervous System - NCBI Bookshelf

    some snippets:

    In humans, Henrotte and Levy-Leboyer (1985) also found an interesting link between HLA-B35, type A personality and low Mg2+ status. HLA-B35 individuals are more frequently found among stress-sensitive type A behaviour subjects and exhibit lower red blood cell Mg levels than non- carriers. Moreover, these individuals show impaired cytotoxicity and higher titres to antibodies after anti-influenza vaccination, data that establish a connection between genetic background, Mg deficiency, stress and autoimmunity. It is generally accepted that, in response to a psychological stressor, type A persons exhibit increased release of catecholamines and cortisol, which consequently lowers Mg levels and increases cardiovascular risk as compared to type B behaviour (Henrotte et al., 1985; Matthews, 1982).

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    Experimental Mg deficiency has also been associated with disrupted sleep patterns. In rats, Mg deficiency is associated with an increased amplitude in daily variation of sleep and slow- wave sleep delta power, and has been noted to shorten life span and lower reproductive ability (Chollet et al., 2001; Motta et al., 1998). In humans, chronic sleep deprivation is associated with progressively decreasing levels of intra- cellular Mg, reduced duration of cardio- pulmonary exercise and increased hyper- sensitivity of the chronotropic response to sympathetic nervous stimulation (Omiya et al., 2009).

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    Sarchielli et al., (1992) showed that sufferers of migraine with and without aura, and tension-type headaches, exhibit significantly lower levels of serum and salivary Mg concentrations. Hypomagnesaemia raises the sensitivity of cerebral arteries to CO2 which in turn favours cerebral vasospasm and headache (Thomas et al., 1994). Despite being controversial, some authors recommend intravenous administration of 1 gram of MgSO4 for the treatment of migraine headache (Durlach et al., 2005).

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    Various studies have also shown that patients with a chronic fatigue condition closely linked to fibromyalgia exhibit low Mg levels that are correlated with total antioxidant capacity of blood and GSH concentrations, but not with lipid peroxidation in vitro (Galland, 1991; Manuel y Keenoy et al., 2000). In these patients, weekly intramuscular injections of 1 gram of MgSO4 resulted in a significant improvement in energy levels, pain, and emotional reactions as measured by the Nottingham health profile score (Cox et al., 1991; Murck, 2002). Durlach et al., (2002) suggest that fibromyalgia and chronic fatigue syndrome are clinical forms of magnesium depletion associated with dysfunction of the biological clock.

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    An interesting correlation has been reported between Mg deficiency and attention-deficit/ hyperactivity disorder (ADHD). Elevated subjective stress levels and stress intolerance is often mentioned as part of the clinical presentation of ADHD, and often these patients present high post-stress cortisol concentrations (Hirvikoski et al., 2009). In a study examining 116 children, 95% of children with this pathology exhibited Mg deficiency (Kozielec and Starobrat- Hermelin, 1997). Although evidence regarding the improvement of ADHD symptoms by Mg supplementation is mixed, some studies indicate that a Mg-B6 regimen over at least two months significantly alleviated hyperactivity and hyperemotivity/aggressiveness and improved attention at school (Mousain-Bosc et al., 2006; Rucklidge et al., 2009). Interestingly, ADHD symptoms reappear in a few weeks after the cessation of the treatment, together with a decrease in erythrocyte Mg values (Mousain-Bosc et al., 2006). A Mg-B6 regimen has also been shown to be effective in the treatment of Tourette’s syndrome. Tourette’s syndrome is associated with increased vulnerability to stress, and Mg deficit is considered to be a central precipitating event (Carrasco and Van de Kar, 2003; Grimaldi, 2002). Hypomagnesemia is linked with exacerbated neural excitability, increased anxiety, orofacial tardive dyskinesia, and migraine, symptoms that are alleviated by the administration of a combination of 0.5 mEq/kg Mg and 2mg/kg vitamin B6 (Garcia- Lopez et al., 2009; Stendig-Lindberg et al., 1998).

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    An inverse correlation between audiogenic stress and erythrocyte Mg levels has been observed (Galland, 1991), and low Mg status has been linked to self-reported noise sensitivity, noise-induced emotional lability and noise- induced feelings of tenseness (Galland, 1991).

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    Interestingly, a correlation has been described between Mg levels (in serum and peritoneal fluid) and stress perception (Jung et al., 2010; Garalejic et al., 2010) in relatively healthy, adult women unable to conceive but without identified organic causes of sterility.

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    In ischemic or hypoxic tissue, Mg antagonizes calcium’s effects and decreases reactive oxygen species production through phopholipases, lipoxygenase and cyclooxygenase pathways. Likewise, in conditions associated with cerebral ischemia, Mg deficiency promotes vasoconstriction of cerebral and coronary arteries, as well as anoxic depolarizations and cortical spreading depression. Accordingly, Mg supplementation potentially plays a neuroprotective role (Turner et al., 2004).

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    Moreover, Mg deficiency increases neuronal calcium influx and consequently augments NO production that is associated with cytotoxic effects (Eby and Eby, 2006). Recent data also indicate a possible link between acute and sudden psychological stress and the appearance of malignant primitive brain tumours (Cabaniols et al., 2010). Furthermore, long-term survivors of brain cancer continue to experience elevated levels of stress as the fear of recurrence increases with time (Keir et al., 2007). Epidemiological data have described an inverse relationship between Mg content in drinking water and incidence of some types of cancers (Maier et al., 2007).

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    In athletes who are subjected to severe physical stress, Mg favourably stabilizes the membrane integrity by binding with phosphate groups of phospholipids located in cell and organelle membranes (Golf et al., 1998). In these subjects, 17 mmol magnesium supplementation per day lowered serum cortisol levels and augmented venous O2 partial pressure leading to better performance. Recent studies indicated that magnesium intake should be at least 260 mg/day for male and 220 mg/day for female athletes (Nielsen and Lukaski, 2006). According to Couzy and colleagues (1990), Mg overdosage in professional sportsmen may lead to hypo- zincemia. The overtraining syndrome described in athletes is also a stress-related condition that designates the exhaustion stage of Selye's general adaptation syndrome. This syndrome is characterized by impairment of psychological processing, systemic inflammatory response, and HPA dysfunction (Angeli et al., 2004). Magnesium deficiency has been reported in this condition.

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    Finally, children hospitalized for respiratory pathology and who received sporadic parental visits exhibited lower serum Mg level and increased excretion of this cation compared to children who received constant parental support (Bednarek et al., 2004). There are also data that suggest Mg deficiency in children brought up in stressful orphanage conditions may lead to a lower intelligence quotient (Manrique et al., 2010; Papadopol et al., 2001)

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    Individuals exhibiting self-damaging behaviour are more likely to present hypomagnesemia as alcohol itself depletes the organism of Mg (Romani, 2008). Depletion of Mg induced in rat astrocytes by alcohol produces disturbances in cytoplasmic and mitochondrial bioenergetic pathways leading to Ca2+ overload, ischemia and stroke (Altura and Altura, 1994). Eating disorders are also commonly linked to hypomagnesemia that may or may not be associated with hypokalemia, hypocalcemia and hypophosphat- emia (Laird Birmingham 2010; Touyz, 2004). This is particularly concerning where the normal western diet is already low in magnesium. For example, in most countries, the magnesium RDA for women varies from 240 to 400mg/day and for adult men varies from 310 to 420mg/day. However, Mg intake in 70% of the western population is less than 400 mg Mg2+ per day, and for approximately 20% of the population this cation intake is less than one-half of the recommended dose (Eby and Eby, 2006). Persons with inadequate nutrition that often accompanies chronic stressful lifestyle need Mg supplementation as increased intake of carbohydrates, fats, exaggerated consumption of coffee and sodas reduce the Mg levels in the organism (Seelig, 1994; Nishimuta, 2007).

    So much good stuff in this book.
     
  2. pinacolada

    pinacolada Member

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    Which oil do you use?
     
  3. OP
    nigma

    nigma Member

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    MgCl2
     
  4. milkboi

    milkboi Member

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    Great post, thanks.
     
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