- Mar 16, 2017
Oh, thats a great find! I was trying to understand how normal cells deal with ROS and stumbled upon this:
New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis
Apparently highly invasive cancers can deal with ROS in the same manner as healthy cells..
"These data indicated that UCP2-mediated mild mitochondrial uncoupling may serve as a tumor promoting event.
The elevated levels of UCP2 in cancer cells may be a result of long-term selection during tumorigenesis, since any event that results in UCP2 upregulation could help cells escape from apoptosis mediated by the p53 signaling. Given the fact that mitochondrial uncoupling could cause dissipation of the mitochondrial potential, a decrease in mitochondrial ROS, and a reduction in p53’s response to oxidative stress, it is reasonable to propose that mitochondrial uncoupling may provide cancer cells with a prosurvival advantage via suppressing the p53 mediated apoptosis pathway."