Acetaminophen: Beyond Pain And Fever Relieving

[What-a-Riot]

Acetaminophen: beyond pain and fever relieving

http://journal.frontiersin.org/article/10.3389/fphar.2011.00072/full

Many studies seem to be designed for the purpose of demonize acetaminophen because it CAN be dangerous. These are often done using human equivalent doses of >10 grams. I think it's worth considering that in proper contexts, acetaminophen can promote healthy longevity. This paper discusses some therepeutic mechanisms beyond perceived relief.

Here's a few quotes of interest

"Naziroglu et al. (2009)also reported acetaminophen (5–100 mg/kg) can reduce brain and microsomal lipid peroxidation, while it also increases brain vitamin E levels and microsomal glutathione peroxidase (GSH-Px) activity."

"Other in vitrostudies showed that acetaminophen can significantly inhibit hemoprotein-induced lipid peroxidation by its ability to reducing ferryl heme to its ferric state and the quenching globin radicals (Boutaud et al., 2010)"

"Usinga HF fed animal model, Shertzer et al. (2010) demonstrated that acetaminophen (30 mg/kg/day) was able to inhibit production of reactive oxygen species (at least partially via inhibition of NADPH oxidase activity) and lipid peroxidation in white adipose tissue (WAT) which improved glucose tolerance and insulin sensitivity in HF animals."

 

[What-a-Riot]

Acetaminophen Improves Protein Translational Signaling in Aged Skeletal Muscle
http://mds.marshall.edu/cgi/viewcontent.cgi?article=1028&context=miir_faculty

Aging-Associated Dysfunction of Akt/Protein Kinase B: S-Nitrosylation and Acetaminophen Intervention
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006430

^human equivalent 3 mg/kg daily for 6 months

 

[What-a-Riot]

Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet.
Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. - PubMed - NCBI

20 mg/kg of acetaminophen, aspirin, ibuprofen, or naproxen to mice

I forget whether the human equivalent dose is 1/8 or 1/12 that of a mouse dose

 

[SOMO]

Acetaminophen: beyond pain and fever relieving

Acetaminophen: Beyond Pain and Fever-Relieving

Many studies seem to be designed for the purpose of demonize acetaminophen because it CAN be dangerous. These are often done using human equivalent doses of >10 grams. I think it's worth considering that in proper contexts, acetaminophen can promote healthy longevity. This paper discusses some therepeutic mechanisms beyond perceived relief.

Here's a few quotes of interest

"Naziroglu et al. (2009)also reported acetaminophen (5–100 mg/kg) can reduce brain and microsomal lipid peroxidation, while it also increases brain vitamin E levels and microsomal glutathione peroxidase (GSH-Px) activity."

"Other in vitrostudies showed that acetaminophen can significantly inhibit hemoprotein-induced lipid peroxidation by its ability to reducing ferryl heme to its ferric state and the quenching globin radicals (Boutaud et al., 2010)"

"Usinga HF fed animal model, Shertzer et al. (2010) demonstrated that acetaminophen (30 mg/kg/day) was able to inhibit production of reactive oxygen species (at least partially via inhibition of NADPH oxidase activity) and lipid peroxidation in white adipose tissue (WAT) which improved glucose tolerance and insulin sensitivity in HF animals."

Pretty sure increased Glutathione activity is tell-tale sign of ROS and/or Liver Damage.

Effect on Vit E could be transient and could be the result of causing damage - local Vit E increases to decrease the damage caused by acetaminophen.

"via inhibition of NADPH oxidase activity"

I'm not sure this is supposed to be inhibited long term. If someone is oxidizing glucose properly, then yes Tylenol is probably a pretty safe drug.

Ibuprofen also causes stomach bleeding, but Tylenol and Aspirin get all the bad rap.

 

[General Orange]

Yeah, it work as a Pro-drug for cannabinoid.

Paracetamol: new vistas of an old drug. - PubMed - NCBI