R. Carthamoides Reduces Corrtisol Induced By PUFA, Restores Adrenal Function

[LeeLemonoil]

https://www.ncbi.nlm.nih.gov/pubmed/24444255

The increase in corticosterone seen in rats given a high fat diet appears to be attenuated by up to 27% when given Rhaponticum carthamoides (300mg/kg of a 2.2% 20-hydroxyecdysone extract) for eight weeks,[3] a reduction that was comparable in magnitude to a similar dose of pomegranate extract containing 40% ellagic acid.[3]Rhaponticum carthamoides was also able to restore corticosterone concentrations in the adrenal glands by 25%, as they were depleted 2.15-fold in the high fat control group, despite pomegranate not having this effect.[3]

They don't specify the fat used in the chow, but since it stimulated corticosteroids, surely PUFAS wre involved.
Interesting effects of this well known old russian medicinal-plant, restoring drained adrenals.
Probably responsible for the effects are mainly the Ecdysteroids in the plant, a filed regrettably underapprecitaed by Peat and this forum:

https://raypeatforum.com/community/threads/plants-and-insects-as-a-source-of-steroids.20213/

 

[LeeLemonoil]

Mol Cell Biochem. 2017 Dec 14. doi: 10.1007/s11010-017-3254-z. [Epub ahead of print]
Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract.
Skała E1, Kowalczyk T2, Toma M3, Szemraj J4, Radek M5, Pytel D6, Wieczfinska J7, Wysokińska H8, Śliwiński T3, Sitarek P8.
Author information
Abstract
The present study is the first investigation of the inhibitory effect of Rhaponticum carthamoides transformed roots (TR) extract on the proliferation of grade II and III human glioma cells. TR extract showed the cytotoxic effect and inhibited the colony formation of both glioma cell lines in dose-dependent manner. The root extract induced apoptosis by increasing of the reactive oxygen species (about threefold compared to the control cells) leading to a disruption of mitochondrial membrane potential. Additionally, the mRNA levels of the apoptotic factors such as Bax, Tp53, caspase-3, and caspase-9 were observed to increase. These results indicate that the TR extract possesses anticancer activity by inhibiting glioma cell proliferation and inducing apoptotic cell death, and may be used as a promising anticancer agent.

 

[managing]

I agree that it is likely that their feed was PUFA rich. Can you explain or elaborate on the connection between PUFA and Cortisol. Do you mean PUFA's disruption of cellular respiration which results in energy deficit thusly stimulating cortisol? or more/more direct?

 

[LeeLemonoil]

look up Peat's writings about PUFAs disruptive/toxic mechanisms, you explained one. SFA decrease cortiol usually, that's why I assumed PUFAS in the op

 

[Lokzo]

Anyone recommend a decent extract of this herb? Looking for a vendor to purchase.