P-ethynylphenylalanine: A Stronger Cousin Of PCPA

[TeslaFan]

The following study describer pEPA, a Tryptophan hydroxylase inhibitor.

p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. - PubMed - NCBI

Notable points:
1. "pEPA is a more potent and specific inhibitor of TPH than p-chlorophenylalanine (pCPA)."
2. "pCPA produced a similar effect .... only at 10 times the concentration"
3. "pEPA displayed little inhibitory activity toward tyrosine hydroxylase ... and no inhibition of phenylalanine hydroxylase or tyrosinase"

So, basically, 1o times less of pEPA is needed to achieve the results of pCPA.

Now, the million dollar question is, @haidut: can you obtain this for research?

 

[Miggie]

Interested in this as well.

 

[tomisonbottom]

The following study describer pEPA, a Tryptophan hydroxylase inhibitor.

p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. - PubMed - NCBI

Notable points:
1. "pEPA is a more potent and specific inhibitor of TPH than p-chlorophenylalanine (pCPA)."
2. "pCPA produced a similar effect .... only at 10 times the concentration"
3. "pEPA displayed little inhibitory activity toward tyrosine hydroxylase ... and no inhibition of phenylalanine hydroxylase or tyrosinase"

So, basically, 1o times less of pEPA is needed to achieve the results of pCPA.

Now, the million dollar question is, @haidut: can you obtain this for research?

Bump

 

[milkboi]

Bump

 

[Gadsie]

Bump

 

[Zellig Pliskin]

Bump