Mouth Ulcers From Supplements

[Tenacity]

I'd like to experiment with niacinamide, but every time I use it I end up getting mouth ulcers about a week later. This happened with pregnenolone too. I thought maybe it was the excipients in the pregnenolone but the niacinamide supplement I'm using lists only gelatin, water (the capsule) and niacinamide as ingredients. I usually open the capsule and put the powder into milk. Does anyone have any ideas on why this is happening and what I can do to prevent it from happening? I'd try different brands but I'm a bit fearful the issue is with me rather than the supplement, seeing as this has happened with two different substances. If it helps, it was Life Extension's pregnenolone and Tudimo Nutrition's niacinamide. Thanks.

 

[Diokine]

This is probably from glucocorticoid antagonism and subsequent immune activation/infiltration. Do you get enough full-spectrum light? Are you supplementing vitamin D? Do you sleep well? How is your digestion? Do you consume a lot of dairy? If so does it taste good?

 

[Tenacity]

This is probably from glucocorticoid antagonism and subsequent immune activation/infiltration.

If this were true, wouldn't I have the same problem with aspirin?

I supplement vitamin D, dairy is fine and one of my favourite foods, digestion appears to be fine. The only issues there are sleep and light; I have hyperadrenergic POTS which results in insomnia and poor sleep, usually resulting in rising in the afternoon, such that I don't get much natural light. It's getting colder out, too.

 

[Diokine]

If this were true, wouldn't I have the same problem with aspirin?

Yes aspirin use may contribute to formation and maintenance of oral tissue ulceration. One way glucocorticoids work is by modulating immune function, and one aspect of this is TNF-alpha antagonism.

Aspirin ingestion impairs oral mucosal ulcer healing by inducing membrane-bound tumor necrosis factor-alpha release.

Our findings indicate that the impairment in buccal ulcer healing by aspirin is a result of upregulation in the processing of soluble TNF-alpha from its membrane-bound precursor that leads to the amplification of apoptotic events and potentiation of the mucosal inflammatory responses that interfere with healing process.

Are you getting enough magnesium, potassium, sodium? Do you get back pain regularly? One aspect of adrenergic fatigue/hypersensitivity is lymph stagnation which can manifest as back pain. Activation of skeletal muscle and coordinated movement is very therapeutic here.

 

[Tenacity]

Aspirin never gave me this problem, and I was using it around the same time I used pregnenolone. I don't use it any more.

With potatoes, milk and orange juice and supplemental salt as staples in my diet I suspect I'm getting enough of the alkali minerals. No back pain.

 

[Peatful]

This is probably from glucocorticoid antagonism and subsequent immune activation/infiltration. Do you get enough full-spectrum light? Are you supplementing vitamin D? Do you sleep well? How is your digestion? Do you consume a lot of dairy? If so does it taste good?

So when dairy tastes weird....
That means?
Thx @Diokine

 

[Ras]

Ever since I started taking high doses of chondroitin sulfate, I do not get aphthous ulcers. I would always get them after biting my lip or cheek, or after eating certain foods, but that no longer happens. I've bitten my lip and cheek several times since I started high doses of chondroitin sulfate, and the wounds simply never become ulcers. They never become anything, nor do I notice them after the bite. It's pretty remarkable, because all my life I could count on a week or two of obnoxious irritation in my mouth every time I bit my lip or cheek, but no more.

It seems to be essential for the healing of soft tissues. Below are links on the cardiovascular benefits of chondroitin sulfate.

The Man Who Cured Heart Disease With a Natural Molecule, 20 Years Before Cholesterol Drugs!

The Forgotten Cure That Prevents Mortal Heart Attacks

Treatment with chondroitin sulfate to modulate inflammation and atherogenesis in obesity

Osteoarthritic patients treated with high doses of chondroitin sulfate (CS) have a lower incidence of coronary heart disease – but the mechanistic aspects of these beneficial effects of CS remain undefined. We examined how CS treatment affects ...

www.ncbi.nlm.nih.gov

Coronary heart disease: reduction of death rate by chondroitin sulfate A - PubMed

Coronary heart disease: reduction of death rate by chondroitin sulfate A

pubmed.ncbi.nlm.nih.gov

CHONDROITIN SULFATE - DCNutrition.com

Chondroitin sulfates (CS) are glycosaminoglycans (GAGs, previously termed mucopolysaccharides) that are large, heterogeneous biological polymers and are used by the body to maintain proper elastic integrity within tissues. Muller (1837) originally obtained a solution of chondrin by steaming...

www.dcnutrition.com

Chondroitin supplementation reduces the risk of myocardial infarction by about forty percent

Supplementation with chondroitin reduces the risk of a heart attack in people with an increased risk of cardiovascular disease. Relatively low doses protect as well as high ones.

www.ergo-log.com

Chondroitin keeps heart patients alive | The Morrison study

Two days ago we wrote about a recent Spanish epidemiological study, in which users of supplements containing chondroitin had fewer heart attacks than non-users. American cardiologist Lester Morrison was already aware of the protective effect of chondroitin decades ago. That's why he treated his...

www.ergo-log.com