Lidocaine Inhibits Collagen Accumulation (Fibrosis)


Sep 9, 2019
Collagen accumulates with aging and causes fibrosis. Although this study only highlights aged donors, it shows that lidocaine antagonizes the pro-fibrotic effects of IGF-1, TGF Beta-1, collagen proteins and inhibits collagen accumulation.

Lidocaine impairs proliferative and biosynthetic functions of aged human dermal fibroblasts


Lidocaine and mepivacaine inhibited proliferation in aged HFB but not in young HFB.

Lidocaine decreased proliferation in aged HFB, which was abrogated by IGF-1. Lidocaine inhibited transcripts for IGF-1 and IGF1R in fibroblasts from aged donors.

Transcripts for collagen III were decreased after lidocaine exposure in aged and young HFB.

Similar to the transcripts, lidocaine also inhibited the protein expression of collagen III in young and aged HFB.


Oct 12, 2020
Does anyone know where to buy Lidocaine in the UK?
Similar threads
Thread starter Title Forum Replies Date
Adrenaline Lidocaine Inhibits Noradrenaline Scientific Studies 9
T What's the rationale behind Ray Peat drinking lidocaine to cure colitis? Digestion 19
bluefish Lidocaine hcl Pharmaceutical Drugs 10
L Lidocaine Might Reverse The Epigenetic Changes Caused By Quitting Smoking And Finasteride Pharmaceutical Drugs 23
Mauritio Lidocaine Is Anti-bacterial And Anti-fungal, Synergistic With Aspirin And Anti-biotics Scientific Studies 25
Adrenaline Lidocaine Protects Liver From Calcium Overload Scientific Studies 0
Adrenaline Lidocaine Is An Endotoxin (TLR4) Antagonist Scientific Studies 19
L Lidocaine Experiences? Supplements, Pharmaceutical Drugs 35
ecstatichamster Have You Tried Neural Therapy: Injecting Procaine Or Lidocaine Science 28
S Dosing Lidocaine Powder Pharmaceutical Drugs 15
gilson d dantas Lidocaine And Prostate Tumor Ask For Help or Advice 4
P Effect Of Lidocaine On Bone Matrix Formation By Osteoblasts Articles & Scientific Studies 2
P Antioxidant Effect Of Lidocaine And Procaine On Reactive Oxygen Species-induced Endothelial Dysfunct Articles & Scientific Studies 6
P Lidocaine Effect On Tnf Alpha And Nitrite After Endotoxin Exposure Articles & Scientific Studies 0
P Antibacterial Activity Of Lidocaine Articles & Scientific Studies 1
P Nebulized Lidocaine Inhalation In The Treatment Of Patients With Acute Asthma Articles & Scientific Studies 0
P Intranasal Lidocaine For Cluster Headaches Articles & Scientific Studies 0
biggirlkisss Lidocaine Orally For Pain Ask For Help or Advice 0
raypeatclips Magnesium Sulfate Can Improve Arrhythmias But Not As Good As Lidocaine Scientific Studies 0
goodandevil RP Email Advice Comment: Lidocaine For Bowel Complaints Email Advice 72
Hugh Johnson Lidocaine Demethylates DNA Articles & Scientific Studies 7
cjm "Vitamin E inhibits the activation of NF‐kB, with the greatest inhibition seen with the succinate form." Scientific Studies 2
H Apigenin inhibits rat neurosteroidogenic 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase Scientific Studies 2
O Doxycycline Inhibits Cancer Stem Cell-Like Properties via PAR1/FAK/PI3K/AKT Pathway in Pancreatic Cancer Scientific Studies 2
A Octreotide Inhibits GH, Serotonin, Prolactin, TSH, Insulin Supplements, Pharmaceutical Drugs 0
Mito Methylene Blue Inhibits the SARS-CoV-2 Spike-ACE2 Protein Miscellaneous Health Discussions 6
shine PQQ inhibits lactate formation, increases lactate to pyruvate conversion, improves NAD+/NADH ratio Scientific Studies 0
haidut Androgens Boost, Estrogen Inhibits, Anti-aging Gene Klotho Scientific Studies 1
haidut Estrogen Lowers T, DHT, And Fertility; Inhibits 5α-Reductase (5-AR) Scientific Studies 13
meatbag Cod-liver Oil Inhibits Gastric Secretion Articles & Scientific Studies 7
Hgreen56 Niacinamide Inhibits Fatloss And Niacin Improve It? Supplements, Pharmaceutical Drugs 10
S.Seneff Russia Compounds That Chelate Iron And Inhibits Potential Mitochlndrial Calcium Overload Scientific Studies 1
S.Seneff Melatonin Inhibits Warburg-dependent Cancer By Redirecting Glucose Oxidation To The Mitochondria Articles & Scientific Studies 2
haidut High-salt Diet Strongly Inhibits Cancer Growth Scientific Studies 12
S COVID-19 Aspirin Inhibits Antibody Production In Human Cells Viruses, Parasites, Fungus, Vaccines 15
GorillaHead Quercetin Inhibits Finasteride From Reducing Serum DHT? Scientific Studies 10
meatbag Lipoic Acid Inhibits NO Synthesis As Powerfully As Methylarginine Scientific Studies 2
meatbag DHEA Inhibits The Activation And Dysfunction Of Endothelial Cells Induced By High Scientific Studies 0
ddjd Why Does Everything That Inhibits 11β-HSD1 (lowers Cortisol) Increase My Belly Fat? Ask For Help or Advice 54
jzeno Capsaicin, A Component Of Red Peppers, Inhibits The Growth Of Mutant Prostate Cancer Cells Scientific Studies 0
Ihor Coffee Inhibits Fats Digestion Coffee 21
Batbat Niacinamide Inhibits Hair Growth B3/Niacinamide 7
E Vitamin D Inhibits Serotonin Reuptake [SERT], Inhibits Serotonin Degradation [MAO], And Increases Se Scientific Studies 49
S Yeast Extract Stimulates Glucose Metabolism And Inhibits Lipolysis In Rat Adipocytes In Vitro Scientific Studies 9
Gadsie Glycine Inhibits Formation Of Blood Vessels In (colon) Tumors Scientific Studies 1
L Oral Exposure To The Free Amino Acid Glycine Inhibits The Acute Allergic Response In A Model Of Cow' Scientific Studies 13
D Estrogen Significantly Inhibits Hepcidine Synthesis Scientific Studies 8
Hans Methylene Blue Inhibits Fatty Acid Oxidation And Improve Metabolic Flexibility In The Heart Supplements, Pharmaceutical Drugs 0
M Is There Anything That Inhibits NNOS And ENOS? Ask For Help or Advice 2
M 3-bp Inhibits Glycolysis And Cures Cancer Scientific Studies 11

Similar threads