Lidocaine Inhibits Collagen Accumulation (Fibrosis)

Adrenaline

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Sep 9, 2019
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96
Collagen accumulates with aging and causes fibrosis. Although this study only highlights aged donors, it shows that lidocaine antagonizes the pro-fibrotic effects of IGF-1, TGF Beta-1, collagen proteins and inhibits collagen accumulation.

Lidocaine impairs proliferative and biosynthetic functions of aged human dermal fibroblasts

Highlights:

Lidocaine and mepivacaine inhibited proliferation in aged HFB but not in young HFB.

Lidocaine decreased proliferation in aged HFB, which was abrogated by IGF-1. Lidocaine inhibited transcripts for IGF-1 and IGF1R in fibroblasts from aged donors.

Transcripts for collagen III were decreased after lidocaine exposure in aged and young HFB.

Similar to the transcripts, lidocaine also inhibited the protein expression of collagen III in young and aged HFB.
 

Pina

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Oct 12, 2020
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245
Does anyone know where to buy Lidocaine in the UK?
 
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