Aspirin alleviates pulmonary fibrosis through PI3K/AKT/mTOR-mediated autophagy pathway
Idiopathic pulmonary fibrosis (IPF) is a chronic and irreversible lung disease with limited therapeutic options. Aspirin can alleviate liver, kidney, …
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Highlights
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Aspirin inhibits pulmonary fibrosis in lung fibroblasts and mice.
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Aspirin induces autophagy.
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Aspirin may block fibroblasts differentiation by inducing autophagy.
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Aspirin induces autophagy by inhibiting PI3K/AKT/mTOR pathway.
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Aspirin ameliorates pulmonary fibrosis through a PI3K/AKT/mTOR-dependent autophagy pathway.