Is there an interaction between serotonin and the angiotensin system in relation to coronavirus infection?

[retroactive]

It seems that covid-19 is related to 1) elevated serotonin (which relates to the lungs via the platelets) and 2) the spike protein affecting the Angiotensin converting enzyme (i believe).

Is there an interaction between these two mechanisms?

 

[mrchibbs]

Absolutely! It's been discussed ad nauseam on this forum, if you search you'll find several threads on the topic. And Ray wrote several newsletters on this very topic too.

 

[retroactive]

Absolutely! It's been discussed ad nauseam on this forum, if you search you'll find several threads on the topic. And Ray wrote several newsletters on this very topic too.

Got a thread for me? I don't see much of the actual link between the two other than they both relate to COVID

 

[retroactive]

Absolutely! It's been discussed ad nauseam on this forum, if you search you'll find several threads on the topic. And Ray wrote several newsletters on this very topic too.

All I've found is this: "Endotoxin commonly increases serotonin and it increases sensitivity to angiotensin." from here: The Dilemma Of Coronavirus Disease 2019, Aging, And Cardiovascular Disease

Is increasing the sensitivity to angiotensin all there is? Thanks

 

[Peatness]

Angiotensin I And II And Serotonin?

Does this study say that angiotensin II would be useful for reducing serotonin: "Ang II administration also increased (by 15% and 55%) the levels of the major serotonin metabolite, 5HIAA. This effect was also abolished by co-administration with Losartan, and Losartan alone depressed basal...

raypeatforum.com

Angiotensin regulates release and synthesis of serotonin in brain - PubMed

Angiotensin II released serotonin from neuron terminals and accelerated synthesis of the serotonin. This increase in synthesis depended on the activation of tryptophan hydroxylase. A biphasic effect was observed: at high doses the stimulatory effect depended on conversion of angiotensin II to...

pubmed.ncbi.nlm.nih.gov

https://www.ahajournals.org/doi/10.1161/circresaha.108.180976

 

[retroactive]

Angiotensin I And II And Serotonin?

Does this study say that angiotensin II would be useful for reducing serotonin: "Ang II administration also increased (by 15% and 55%) the levels of the major serotonin metabolite, 5HIAA. This effect was also abolished by co-administration with Losartan, and Losartan alone depressed basal...

raypeatforum.com

Angiotensin regulates release and synthesis of serotonin in brain - PubMed

Angiotensin II released serotonin from neuron terminals and accelerated synthesis of the serotonin. This increase in synthesis depended on the activation of tryptophan hydroxylase. A biphasic effect was observed: at high doses the stimulatory effect depended on conversion of angiotensin II to...

pubmed.ncbi.nlm.nih.gov

https://www.ahajournals.org/doi/10.1161/circresaha.108.180976

Thanks!