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Famotidine Has Antibiotic Actions, Esp Against E. Coli

Discussion in 'Pharmaceutical Drugs' started by nullredvector, Sep 18, 2016.

  1. nullredvector

    nullredvector Member

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    Background: Selective antihistamine receptor type 2 blockers like famotidine, ranitidine and cimetidine are widely used for treatment of peptic ulcer, and because many nonantibiotics agents have antibacterial activity. Aims:This study aimed to evaluate the antibacterial effects of famotidine, ranitidine and cimetidine. Material and methods: Tewnty two of bacterial isolates were selected and obtained from National Chemical Laboratory (NCL), from conjunctiva: 5 Staphylococcus aureus, 5 Escherichia coli,6 Pseudomonas aeruginosa and (6)Klebsiella pneumoniae. The drug s effects determined by Agar disc diffusion and Agar well diffusion methods,then evaluation done through measurement of zone of inhibition and minimal inhibitory concentration(MIC). Results: Results showed that cimetidine and ranitidine have non significant and negligible antibacterial effects, while famotidine have significant antibacterial effects (P? 0.01) against Escherichia coli (MIC8mg/ml and inhibition zone 25mm) and moderately against Staphylococcus aureus. Conclusions: famotidine have significant antibacterial activity especially against Escherichia coli
    MJB Journal : Evaluation of Antibacterial Activity of Famotidine, Ranitidine and Cimetidine: In Vitro Study
     
  2. TubZy

    TubZy Member

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    Sep 30, 2016
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    Sweet, thanks
     
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