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Calcirol - Liquid Vitamin D3

Discussion in 'IdeaLabs' started by haidut, Dec 10, 2017.

  1. Amazoniac

    Amazoniac Member

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    Rayzord mentioned in an interview that calcium and vit D are correlated with leanness. I wonder if fat loss starts to occur only once tissues are saturated with vit D. Maybe gurus give up too soon and feel well all of the sudden for misterious reasons while fasting (not an attack to gbolduev); or they take too much at a time and feel the temporary bad effects of excess calcium.

    Meet Klotho.

    And congratulations.
     
  2. High_Prob

    High_Prob Member

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    Has anyone seen this?



    The Big Vitamin D Mistake. - PubMed - NCBI

    The Big Vitamin D Mistake.
    Papadimitriou DT1,2.
    Author information

    Abstract
    Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities' decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical. A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L. Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L. The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality, demolishing the previously presumed U-shape curve of mortality associated with vitamin D levels. Since all-disease mortality is reduced to 1.0 with serum vitamin D levels ≥100 nmol/L, we call public health authorities to consider designating as the RDA at least three-fourths of the levels proposed by the Endocrine Society Expert Committee as safe upper tolerable daily intake doses. This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency.
     
  3. OP
    haidut

    haidut Member

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    Carbonate, bicarbonate, taurate, glycinate, gluconate are all good salts to try.
     
  4. OP
    haidut

    haidut Member

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    It is the very first one, top left corner on my screen, just before EstroBan.
     
  5. OP
    haidut

    haidut Member

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    Yes, thanks for posting. I was reading it about 2 weeks ago. If you read through the study, there is a statement in the concluding section where it says that doses of up 10,000 IU in adults and 3,000 IU for children are VERY safe and can be done without ANY medical supervision. I think vitamin D has been very seriously underestimated and in some cases purposefully denigrated. Pharma has quite a few bone-anabolic agents in trials that are derivatives of vitamin D. They claim those are safer because they were developed to not have risk of hypercalcemia, but the animal studies I have seen all show terrible side effects like heart failure and breast cancer that are notably absent in the plain vitamin D control groups.
     
  6. Vinero

    Vinero Member

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    Interesting product but I think I'll stick to using Estroban, as that also has vitamins A and K, which are needed to protect against side effects of vitamin D. Do you think it's beneficial to use vitamin D on its own?
     
  7. OP
    haidut

    haidut Member

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    The sooner we start thinking of "vitamin" D as a steroid the faster the public perception will change. Vitamin D binds to and modulates all major hormone receptors including thyroid, estrogen, glucocorticoid, androgen and mineralocorticoid ones. Thus a deficiency in this secosteroid by definition induces a state of systemic abnormal steroid signalling.
     
  8. OP
    haidut

    haidut Member

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    I think it may help for people who think they need higher doses, and also for people who want to stack it with the steroids like pregnenolone, progesterone, DHEA, thyroid, and the androgens.
     
  9. alywest

    alywest Member

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    Ray Peat said he uses about 20,000 IU/day
     
  10. raypeatclips

    raypeatclips Member

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    That was topically.
     
  11. alywest

    alywest Member

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    Cool, thanks for clarifying that.
     
  12. jb116

    jb116 Member

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    Yes he said you need about 10x more with topical use.
     
  13. alywest

    alywest Member

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    So you really only want 200oIU orally or 20000 topically? He has also said that 10000 IU would be the equivalent of spending time in the sun and isn't harmful
     
  14. Lee Simeon

    Lee Simeon Member

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    I tried on another browser and it worked then. Still does not work on Torch though. Hmmmmmm...
     
  15. GAF

    GAF Member

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    upload_2017-12-11_14-14-18.png

    it is showing up in a funky way on my Internet Explorer 11 but the blue link works to take you to the product
     
  16. OP
    haidut

    haidut Member

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    Can you please post a screenshot?
     
  17. OP
    haidut

    haidut Member

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    It was an HTML typo, it should be fixed now.
     
  18. Lee Simeon

    Lee Simeon Member

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    upload_2017-12-11_21-34-13.png
    This is Torch
     
  19. Amazoniac

    Amazoniac Member

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    A pilot study assessing the effect of prolonged administration of high daily doses of vitamin D on the clinical course of vitiligo and psoriasis

    "High-dose vitamin D3 supplementation to patients with autoimmune disorders is conceivably advantageous over 1,25(OH)2D3 treatment concerning lower calcemic effects and more efficient control of autoimmunity. Administration of 1,25(OH)2D3 or 1,25(OH)2D3 analogs overpasses critical regulatory mechanisms related to the calciotropic effects of vitamin D by directly stimulating intestinal VDR and calcium absorption. In contrast, administration of vitamin D3 increases circulating concentrations of 25(OH)D3, which then faces different renal and extra-renal control mechanisms for expression and activity of the enzyme 1 α-hydroxylase.41 Renal 1 α-hydroxylase undergoes feedback downregulation (associated with 24-hydroxylase upregulation) by 1,25(OH)2D3 and 1,25(OH)2D3 production is also under strict control of other calcium- and phosphate-regulating hormones (PTH and FGF23).51 Conversely, the availability of 25(OH)D3 to immune cells (the production of which is not tightly controlled by the liver)37 may be the primary determinant of the amount of 1,25(OH)2D3 produced for intracrine and paracrine effects at sites of inflammation,50 where the local expression of cytokines may instead facilitate the conversion of 25(OH)D3 by inducing the expression of 1 α-hydroxylase.51,52

    Hypervitaminosis D is associated with upregulation of intestinal VDR and increased absorption of dietary calcium.53 A low calcium diet protects against vitamin D toxicity, not only by reducing the availability of calcium for gastrointestinal absorption, but also by facilitating vitamin D inactivation at sites related to calcium metabolism.37 Reduced intestinal calcium by dietary restriction of milk, dairy products and calcium-enriched foods (like oat, rice or soya “milk”) has contributed to minimize the calciotropic effects of high daily doses of vitamin D3 in the current study. Increased gastrointestinal absorption of calcium is partly responsible for the hypercalcemia in vitamin D intoxication and a low dietary calcium intake gradually reduces serum calcium in such patients.54 Preliminary data (not shown) obtained from patients treated with progressively higher doses of vitamin D3 up to 35,000 IU daily showed that the adoption of such easily understandable dietary recommendations reduced urinary calcium from borderline elevated levels (around 400 mg or 10 mmol per day, with serum calcium sustained at the upper normal range) to values within the normal range without changing vitamin D daily dose. Further restriction of dietary calcium (by also avoiding foods prepared with milk, such as mashed potatoes, bread, cakes and cookies) dropped urinary calcium to levels below the lower limit of the normal range adopted by the local laboratory (100 mg or 2.5 mmol per day) while serum calcium remained around the lower limit (8.6 mg/dL or 2.15 mmol/L).

    Taken together, those data suggest that partial dietary calcium restriction efficiently prevents hypercalcemia and hypercalciuria by controlling the gastrointestinal availability of calcium under the calciotropic effect of the treatment paradigm employed in patients with psoriasis and vitiligo in this study."

    "serum concentration of PTH may be the best biological indicator for the individual setting of the optimal therapeutic dose of vitamin D3 for the treatment of autoimmune disorders"

    "A period of at least 2 mo should be allowed between the two serum PTH measurements, considering that 25(OH)D3 has a half-life of 15 d.48 Using the PTH level as an ancillary index of therapeutic response requires a diet only partially restricted in calcium (like the one described in this study) since excessive restriction of calcium intake would maintain increased bone resorption to preserve normocalcemia, thereby limiting or preventing vitamin D3-induced PTH drop."

    The guru also advocates maintaining PTH value close to the lowest of the normal range.

    "all patients excluded milk and dairy products (as well as calcium-fortified foods like soy, oat or rice milk) from their diet and ingested at least 2.5 L of fluid per day to prevent, respectively, excessive absorption of intestinal calcium and concentrated urinary calcium. Calcium supplementation was not allowed. The onset of symptoms suggestive of hypercalcemia (increased thirst, constipation, nausea, vomiting) would require performing extra laboratory tests."​

    __
    Have you ever searched for ""vit d" isotretinoin"?
     
  20. OP
    haidut

    haidut Member

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    It probably cached the previous version of the page. Try doing a reload with CTRL+R.
     
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