anabolic

  1. haidut

    Vitamin D is anti-catabolic / anabolic, protects liver from cortisol injury

    In a recent post of mine I discussed the effects of cortisol on various aminotransferases (especially TAT), their role as biomarkers of catabolism, and how inhibitors of said aminotransferases have a potent anti-catabolic / anabolic effects. In that same post, I also described how cortisol (a...
  2. haidut

    PUFA is catabolic, SFA is anti-catabolic (anabolic)

    During the early days of anabolic-androgenic steroid (AAS) science, it quickly became apparent that the ability of AAS to preserve and/or increase muscle mass was related to their ability to reduce/block the expression of amino acid catabolic enzymes such as tyrosine aminotransferase (TAT). TAT...
  3. haidut

    Glucose Is Anabolic For Thymus, Opposes Catabolic Effects Of Cortisol

    As most of my readers know, cortisol is a highly catabolic steroid and one of the main agents (estrogen being another) responsible for thymus atrophy with age. These catabolic effects of cortisol can be blocked by progesterone, DHEA, pregnenolone, and even DHT (but not by testosterone). The...
  4. haidut

    Cholesterol And SFA Are Anabolic; PUFA/MUFA Akin To Chemical Castration

    A pair of interesting study and a commentary in the highly respected Journals of Gerontology. Namely, higher cholesterol intake is associated with much higher lean muscle mass accrual as a result of weight lifting. Interestingly, higher protein intake was not. Even more interestingly, and much...
  5. haidut

    Blocking Estrogen In Brain Strikingly Anabolic For Female Muscles / Bones

    In yet another great example of "synchronicity" (Synchronicity - Wikipedia), just a few days after posting the study on lack of estrogen and muscle growth, another fascinating study popped into my mailbox. Estrogen Is NOT Needed For Either Muscle Or Bone Growth / Anabolism Now, the study below...
  6. haidut

    Estrogen Is NOT Needed For Muscle / Bone Growth And Anabolism

    I have had my eye on posting this study for at least 3 years now but something more important always came up, so I kept putting it off. However, the recent thread posted on the forum about how estrogen is "essential" for health convinced me it is way overdue that I post something on this topic...
  7. haidut

    Pregnenolone Is Anabolic For Bones

    So much for pregnenolone being an inactive steroid. The study below shows that even very low concentrations of pregnenolone are high anabolic for the bone and its effects are comparable to those of potent steroids like DHT or the well-known androgenic-anabolic steroid (AAS) commonly known as...
  8. haidut

    A Proposed Anabolic Mechanism Of Tribulus Terrestris (TT)

    Some people on the forum like @Wagner83 myself and a few others have tried the infamous herb TT with the hope of raising androgens and improving body composition. Despite Wikipedia bashing TT and raising doubts about its effectiveness, there is plenty of evidence from human trials shows the herb...
  9. haidut

    PUFA Is Directly Catabolic (without Cortisol/estrogen), SFA Is Anabolic

    I posted a few studies about PUFA potentiating the stress response and cortisol synthesis, even without the typical elevations of ACTH present in organic stress reactions. Saturated fats block that pro-stress effects of PUFA...
  10. haidut

    Calcirol - Liquid Vitamin D3

    Just like the other vitamin products we have released, this product does not really need any introduction to anybody familiar with Peat's work. So, unlike other products of ours, there won't be as many references listed in support of this product but I think even the few ones below are enough to...
  11. haidut

    CortiNon - Liquid Progesterone/DHEA Mix

    This product does not really need any introduction to anybody familiar with Peat's work. I have wanted to release it for a long time but over the last few months the studies I found related to the anabolic and anticatabolic effects of progesterone, combined with the fact that Peat has told quite...
  12. haidut

    Glycine Is Directly Anabolic AND Anticatabolic For The Muscle

    I posted a few interesting studies about glycine in the past. Among the interesting properties are lowering cortisol, increasing DHT synthesis, improving insulin sensitivity, and serving as a biomarker of stress. Glycine Powerfully Lowers Cortisol Glycine Strongly Upregulates 5-alpha Reductase...
  13. haidut

    Progesterone Is As Anabolic For Muscle As Testosterone (in Women)

    I am posting this in support of the recent thread on what constitutes an anabolic supplement steroid and how to properly combine various steroids to help prevent/limit catabolism and enhance anabolism in both men and women. Quest For The Perfect Anticatabolic / Anabolic Supplement This study...
  14. haidut

    Structural Requirements For An Optimal Anti-Catabolic Steroid

    This post will be a bit long, but I hope it is worth it. I think @Jsaute21 and @dand will find it highly interesting but the information here applies just as much to females wishing to preserve lean tissue and prevent the catabolism that often occurs with aging. Here we go. Lately, I have been...
  15. haidut

    The Anabolic Effects Of Progesterone

    As I mentioned in a few other recent threads, even though it is laughed at in the bodybuilding world progesterone has been shown to have anabolic properties. I already posted about the anabolic effects of pregnenolone, but that study did not use the "standard" levator ani test. The Anabolic...
  16. haidut

    The Anabolic Effects Of Pregnenolone

    I posted a few studies showing pregnenolone has anti-cortisol and anti-estrogen effects, which make it anti-catabolic by definition. However, older studies referred to pregnenolone as an anabolic steroid and some of them examined its anabolic effects. While pregnenolone was not as potent as...
  17. haidut

    The Trophic Effects Of Androsterone

    As I mentioned in a few past threads, androsterone was studied intensively in the first half of the 20th century and one of the reasons was its functional similarity to thyroid. In addition to its hypocholesterolemic effect androsterone was also found to be highly trophic to a number of organs...
  18. haidut

    The Antidepressant Mechanism Of Androsterone

    There is solid evidence that androgens have potent antidepressant effects in both sexes. However, the mechanism of action of that antidepressant effect has not been fully elucidated yet. On the other hand, it is also well known that chemicals that increase the levels of the so-called...
  19. haidut

    Androsterone - Liquid Androsterone For Lab/R&D

    EDIT: Since I keep getting questions about androsterone, here is Ray's response when asked about it: Ray Peat Email Advice Depository Discussion/Comment Thread "...I think it would be safe enough to try in treating cancer or brain degenerative diseases." Here is one reference that gives backing...
  20. haidut

    Remarkable Synergistic Effect Of Androsterone With DHEA

    The steroids androsterone (A) and DHEA are considered not very strong androgens in terms of direct activity on androgenic receptors. DHEA is often cited as having 1/10 of the androgenic effects of testosterone (T) and androsterone as having 1/7 of the androgenic effects. While that has been...
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