Blocking cortisol may treat terminal pancreatic cancer

haidut

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Recently, I made a post about some truly amazing results in treating terminal cancer patients with the glucocorticoid/progesterone antagonist Mifepristone (RU486). Some of the cases were stage 4 and possibly terminal. Now, a new case study below reports possibly curative effects on a confirmed terminal case of pancreatic cancer using 200mg daily dose of RU486. The patient went from being assigned to a hospice and taking a morphine drip for pain to an almost fully functional state. His cancer was officially re-categorized from stage 4 down to stage 2. The patient was well on his way to perhaps complete cure, however he felt that he was a burden on his children, could not afford the $500 a month for RU486, and decided to stop the treatment. His cancer returned and he died a few weeks after stopping the RU486 treatment. Interestingly enough, the case report mentions that the patient had obtained RU486 without prescription and was considering self-treatment due to his son informing him of the recent successful studied with that drug in advanced cancers. This suggests the general public is becoming aware of such "alternative" therapies targeting the metabolic nature of cancer, which gives me hope that more and more people will start rejecting the guaranteed death sentences handed out by mainstream oncologists, and will take treatment matters into their own hands. As I mentioned in the previous RU486 post referenced above - despite the amazing effects, this drug is not without side effects, is expensive, and very had to get a doctor to prescribe. Progesterone, being a natural glucocorticoid antagonist, is widely available (usually without prescription), cheap and with much better side effects profile compared to RU486. Based on receptor affinity studies, progesterone should be able to replicate the effects of 200mg RU486 daily when used in doses of 250mg-500mg daily.

Treatment With Mifepristone Allows a Patient With End-stage Pancreatic Cancer in Hospice on a Morphine Drip to Restore a Decent Quality of Life - PubMed
"...Pancreatic cancer has one of the highest mortality rates among all malignancies, with a 5-year survival rate of about 20% (1-3). There are multiple reasons for the poor prognosis of patients with pancreatic cancer, including the failure to present with symptoms until the cancer has already reached an advanced stage, thus precluding early detection (4). Other factors include the aggressive nature of the pancreatic cancer itself, and the lack of highly successful chemotherapy or immunotherapy (5)."

"...A 57-year-old man was admitted to the hospital for severe abdominal pain, and vomiting (25 time per day), along with dyspnea on exertion, and weakness. He was found to have extensive pancreatic cancer. His oncologist advised him that the cancer was so extensive that there was no anti-cancer therapy that could be rendered. He was advised that hospice was the only solution. He was hospitalized on a morphine drip preparing to die within 1-3 weeks. However, his son had a friend who knew of the use of mifepristone therapy for a variety of cancers (12). He was finally taken out of hospice and placed on oral single agent mifepristone 200 mg daily, administered from his home, after obtaining a compassionate use investigational new drug (IND) approval from the United States Food and Drug Administration (FDA). When a compassionate use IND from the FDA is obtained, generally 3 months of mifepristone is purchased at one time. The drug costs about $500 per month, with a discount for patients with cancer from the Danco Pharmaceutical company. He did not have $1500, plus it would be wasted if he died 2 weeks later. We agreed to buy it for him and sell him 10 pills at a time. He was slumped over in a wheelchair when he first presented and was considered ECOG-4. Within 2 months, in taking single agent oral mifepristone 200 mg daily, he had no pain or vomiting, his weakness was much less, and he was able to walk without assistance. After 5 months of therapy he did not require any analgesics or anti-emetics, and only complained of mild dyspnea on exertion, and mild weakness. He was considered ECOG-2."

"...At nine months his depression worsened, because he was having trouble affording the drug, and he felt that he was a burden to his family. Thus, at nine months, in stable condition, he elected to stop mifepristone therapy. His pain and vomiting returned within 2 weeks, and was placed in hospice once again. He died 2 weeks later."
 

Summer

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I wonder if this can be used in tandem with aspirin and progesterone.
 

karliin

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From what i understand, mifepristone can be purchased in India, but have been unable to find any for sale. Sounds like it could be an effective strategy for a patient with pancreas cancer. If anyone has had luck purchasing mifepristone, kindly share vendor. thank you
 

Mr.Bollox

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From what i understand, mifepristone can be purchased in India, but have been unable to find any for sale. Sounds like it could be an effective strategy for a patient with pancreas cancer. If anyone has had luck purchasing mifepristone, kindly share vendor. thank you
Recently, I made a post about some truly amazing results in treating terminal cancer patients with the glucocorticoid/progesterone antagonist Mifepristone (RU486). Some of the cases were stage 4 and possibly terminal. Now, a new case study below reports possibly curative effects on a confirmed terminal case of pancreatic cancer using 200mg daily dose of RU486. The patient went from being assigned to a hospice and taking a morphine drip for pain to an almost fully functional state. His cancer was officially re-categorized from stage 4 down to stage 2. The patient was well on his way to perhaps complete cure, however he felt that he was a burden on his children, could not afford the $500 a month for RU486, and decided to stop the treatment. His cancer returned and he died a few weeks after stopping the RU486 treatment. Interestingly enough, the case report mentions that the patient had obtained RU486 without prescription and was considering self-treatment due to his son informing him of the recent successful studied with that drug in advanced cancers. This suggests the general public is becoming aware of such "alternative" therapies targeting the metabolic nature of cancer, which gives me hope that more and more people will start rejecting the guaranteed death sentences handed out by mainstream oncologists, and will take treatment matters into their own hands. As I mentioned in the previous RU486 post referenced above - despite the amazing effects, this drug is not without side effects, is expensive, and very had to get a doctor to prescribe. Progesterone, being a natural glucocorticoid antagonist, is widely available (usually without prescription), cheap and with much better side effects profile compared to RU486. Based on receptor affinity studies, progesterone should be able to replicate the effects of 200mg RU486 daily when used in doses of 250mg-500mg daily.

Treatment With Mifepristone Allows a Patient With End-stage Pancreatic Cancer in Hospice on a Morphine Drip to Restore a Decent Quality of Life - PubMed
"...Pancreatic cancer has one of the highest mortality rates among all malignancies, with a 5-year survival rate of about 20% (1-3). There are multiple reasons for the poor prognosis of patients with pancreatic cancer, including the failure to present with symptoms until the cancer has already reached an advanced stage, thus precluding early detection (4). Other factors include the aggressive nature of the pancreatic cancer itself, and the lack of highly successful chemotherapy or immunotherapy (5)."

"...A 57-year-old man was admitted to the hospital for severe abdominal pain, and vomiting (25 time per day), along with dyspnea on exertion, and weakness. He was found to have extensive pancreatic cancer. His oncologist advised him that the cancer was so extensive that there was no anti-cancer therapy that could be rendered. He was advised that hospice was the only solution. He was hospitalized on a morphine drip preparing to die within 1-3 weeks. However, his son had a friend who knew of the use of mifepristone therapy for a variety of cancers (12). He was finally taken out of hospice and placed on oral single agent mifepristone 200 mg daily, administered from his home, after obtaining a compassionate use investigational new drug (IND) approval from the United States Food and Drug Administration (FDA). When a compassionate use IND from the FDA is obtained, generally 3 months of mifepristone is purchased at one time. The drug costs about $500 per month, with a discount for patients with cancer from the Danco Pharmaceutical company. He did not have $1500, plus it would be wasted if he died 2 weeks later. We agreed to buy it for him and sell him 10 pills at a time. He was slumped over in a wheelchair when he first presented and was considered ECOG-4. Within 2 months, in taking single agent oral mifepristone 200 mg daily, he had no pain or vomiting, his weakness was much less, and he was able to walk without assistance. After 5 months of therapy he did not require any analgesics or anti-emetics, and only complained of mild dyspnea on exertion, and mild weakness. He was considered ECOG-2."

"...At nine months his depression worsened, because he was having trouble affording the drug, and he felt that he was a burden to his family. Thus, at nine months, in stable condition, he elected to stop mifepristone therapy. His pain and vomiting returned within 2 weeks, and was placed in hospice once again. He died 2 weeks later."

where can we get RU486?
also, how can a progesterone antagonist have such good effects, and even have similarities to progesterone itself? wouldnt a progesterone antagonist have severe side effects, if progesterone is the king of hormones etc?
what are the side effects of it?
this thing supposedly makes people lean out, are there a lot of women using it for abortion? seems odd its used as an abortion drug, but also seems very difficult to get even as a prescription...
 
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do you know where we can get it, also how come ru486 has such positive effects while being a progesterone antagonist...

I think it’s a cortisol blocker more than anything else. And a progesterone receptor agonist. It can cause sone cancer to progress.
The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Hereby, we analyzed the effects of MF treatment on Leydig cell tumor (LCT) progression in a transgenic mouse model (inhibin-α promoter-driven SV40 T-antigen), as well as on LCT (BLTK-1 and mLTC-1) cell proliferation. MF significantly stimulated the proliferation of LCT in vitro. Similarly, a 1-mo MF or P4 treatment stimulated LCT tumor growth in vivo. Traceable/absent classical Pgr or nonclassical membrane PRs α, β, γ and Pgrmc2, but abundant membrane Pgrmc1 expression, was found in LCTs. MF did not activate glucocorticoid or androgen receptors in LCTs. Functional analysis showed that PGRMC1 is required for MF and P4 to stimulate the proliferation and invasiveness of LCTs. Accordingly, MF and P4 induced PGRMC1 translocation into the nucleus and thereby stimulated the release of TGFβ1 in LCT cells. MF and P4 treatments upregulated Tgfbr1, Tgfbr2, and Alk1 expression and stimulated TGFβ1 release in LCT cells. Our findings provide novel mechanistic insights into the action of MF as a membrane PR agonist that promotes LCT growth through PGRMC1 and the alternative TGFβ1 signaling pathway.
 
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Joined
Mar 29, 2013
Messages
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Recently, I made a post about some truly amazing results in treating terminal cancer patients with the glucocorticoid/progesterone antagonist Mifepristone (RU486). Some of the cases were stage 4 and possibly terminal. Now, a new case study below reports possibly curative effects on a confirmed terminal case of pancreatic cancer using 200mg daily dose of RU486. The patient went from being assigned to a hospice and taking a morphine drip for pain to an almost fully functional state. His cancer was officially re-categorized from stage 4 down to stage 2. The patient was well on his way to perhaps complete cure, however he felt that he was a burden on his children, could not afford the $500 a month for RU486, and decided to stop the treatment. His cancer returned and he died a few weeks after stopping the RU486 treatment. Interestingly enough, the case report mentions that the patient had obtained RU486 without prescription and was considering self-treatment due to his son informing him of the recent successful studied with that drug in advanced cancers. This suggests the general public is becoming aware of such "alternative" therapies targeting the metabolic nature of cancer, which gives me hope that more and more people will start rejecting the guaranteed death sentences handed out by mainstream oncologists, and will take treatment matters into their own hands. As I mentioned in the previous RU486 post referenced above - despite the amazing effects, this drug is not without side effects, is expensive, and very had to get a doctor to prescribe. Progesterone, being a natural glucocorticoid antagonist, is widely available (usually without prescription), cheap and with much better side effects profile compared to RU486. Based on receptor affinity studies, progesterone should be able to replicate the effects of 200mg RU486 daily when used in doses of 250mg-500mg daily.

Treatment With Mifepristone Allows a Patient With End-stage Pancreatic Cancer in Hospice on a Morphine Drip to Restore a Decent Quality of Life - PubMed
"...Pancreatic cancer has one of the highest mortality rates among all malignancies, with a 5-year survival rate of about 20% (1-3). There are multiple reasons for the poor prognosis of patients with pancreatic cancer, including the failure to present with symptoms until the cancer has already reached an advanced stage, thus precluding early detection (4). Other factors include the aggressive nature of the pancreatic cancer itself, and the lack of highly successful chemotherapy or immunotherapy (5)."

"...A 57-year-old man was admitted to the hospital for severe abdominal pain, and vomiting (25 time per day), along with dyspnea on exertion, and weakness. He was found to have extensive pancreatic cancer. His oncologist advised him that the cancer was so extensive that there was no anti-cancer therapy that could be rendered. He was advised that hospice was the only solution. He was hospitalized on a morphine drip preparing to die within 1-3 weeks. However, his son had a friend who knew of the use of mifepristone therapy for a variety of cancers (12). He was finally taken out of hospice and placed on oral single agent mifepristone 200 mg daily, administered from his home, after obtaining a compassionate use investigational new drug (IND) approval from the United States Food and Drug Administration (FDA). When a compassionate use IND from the FDA is obtained, generally 3 months of mifepristone is purchased at one time. The drug costs about $500 per month, with a discount for patients with cancer from the Danco Pharmaceutical company. He did not have $1500, plus it would be wasted if he died 2 weeks later. We agreed to buy it for him and sell him 10 pills at a time. He was slumped over in a wheelchair when he first presented and was considered ECOG-4. Within 2 months, in taking single agent oral mifepristone 200 mg daily, he had no pain or vomiting, his weakness was much less, and he was able to walk without assistance. After 5 months of therapy he did not require any analgesics or anti-emetics, and only complained of mild dyspnea on exertion, and mild weakness. He was considered ECOG-2."

"...At nine months his depression worsened, because he was having trouble affording the drug, and he felt that he was a burden to his family. Thus, at nine months, in stable condition, he elected to stop mifepristone therapy. His pain and vomiting returned within 2 weeks, and was placed in hospice once again. He died 2 weeks later."

Huge thanks for this post, Georgi. A family member has terminal pancreatic cancer, and this seems to be a promising case study, considering the disease is considered by oncologists to be hopeless. Any further studies you've found following this link would be greatly appreciated.

Perhaps unsurprisingly, peat favourite vitamin k has also been found to be active against pancreatic cancer cell lines by promoting apoptosis.
 

Mr.Bollox

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I think it’s a cortisol blocker more than anything else. And a progesterone receptor agonist. It can cause sone cancer to progress.
The selective progesterone receptor modulator mifepristone (MF) may act as a potent antiproliferative agent in different steroid-dependent cancers due to its strong antagonistic effect on the nuclear progesterone receptor (PGR). Hereby, we analyzed the effects of MF treatment on Leydig cell tumor (LCT) progression in a transgenic mouse model (inhibin-α promoter-driven SV40 T-antigen), as well as on LCT (BLTK-1 and mLTC-1) cell proliferation. MF significantly stimulated the proliferation of LCT in vitro. Similarly, a 1-mo MF or P4 treatment stimulated LCT tumor growth in vivo. Traceable/absent classical Pgr or nonclassical membrane PRs α, β, γ and Pgrmc2, but abundant membrane Pgrmc1 expression, was found in LCTs. MF did not activate glucocorticoid or androgen receptors in LCTs. Functional analysis showed that PGRMC1 is required for MF and P4 to stimulate the proliferation and invasiveness of LCTs. Accordingly, MF and P4 induced PGRMC1 translocation into the nucleus and thereby stimulated the release of TGFβ1 in LCT cells. MF and P4 treatments upregulated Tgfbr1, Tgfbr2, and Alk1 expression and stimulated TGFβ1 release in LCT cells. Our findings provide novel mechanistic insights into the action of MF as a membrane PR agonist that promotes LCT growth through PGRMC1 and the alternative TGFβ1 signaling pathway.
progesterone receptor antagonist? i think ru486 works against cortisol and progesterone right...
isnt cortisol made from progesterone initially, so ru486 is a surefire way to lower cortisol, whereas other substances that only focus on cortisol may not actually reduce it
can we use any studies with ru486 and apply to progesterone or other cortisol blockers? it seems to be a one of a kind cortisol blocker, as it blocks cortisol and progesterone? someone on twitter or maybe another website posted crazy results of a woman losing like over 100 pounds in a year of treatment with ru486 i think it was for cushings treatment... she went from very overweight and ugly looking to very sexy like she got plastic surgery
 

Mr.Bollox

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Factors That Decrease Glucocorticoid Receptor Activity


1) Natural Substances

-- High vitamin B6
-- Curcumin
-- Luteolin

2) Drugs

-- Mifepristone
-- Ketoconazole
-- RU-43044

do you want to have more sensitivity to glucocorticoids or less?
that site is mentioning a glucorticoid resistance effect
 

Mr.Bollox

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Messages
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@haidut you mentioned RU486 in the recent podcast, can its effects be ascribed solely to blocking cortisol, and can its positive effects be applicable to progesterone as well? doesnt RU486 block both cortisol and progesterone, and possibly other things too. this makes it much different than progesterone, pregnenolone, dhea etc...? theres pictures online of some woman using it for cushings treatment, lost like 100+ pounds in a year, went from looking very overweight and ugly to looking like a model with a sharp chiseled jaw and face
 
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