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Effect of pyridoxine on mice gastric ulcers and brain catecholamines after an immobilization stress. - PubMed - NCBI
Ann Nutr Metab. 1992;36(5-6):313-7.
Effect of pyridoxine on mice gastric ulcers and brain catecholamines after an immobilization stress.
Henrotte JG1, Franck G, Santarromana M, Nakib S, Dauchy F, Boulu RG.
"Fifty adult female Swiss albino mice were injected with either 1.11 mg/kg body weight pyridoxine or saline, subsequently they were all submitted to an immobilization stress with a complete fast for 17 h."
"In the stressed animals, the average number of gastric ulcers per mouse was twice as large in the saline-treated group than in the pyridoxine-treated group (p < 0.05)."
"Brain norepinephrine content was almost identical in fasting controls and in stressed mice treated with pyridoxine; in the stressed animals treated with saline, the average norepinephrine content was higher by 15% and in the fed controls lower by 11% than in the two preceding groups. Pyridoxine treatment entailed a very significant reduction (p < 0.002) of norepinephrine variability, mainly due to the absence of high values (> or = 750 ng/g of fresh brain) which occurred only in the saline-treated group."
"These results suggest the antistress effect of pyridoxine."
Ann Nutr Metab. 1992;36(5-6):313-7.
Effect of pyridoxine on mice gastric ulcers and brain catecholamines after an immobilization stress.
Henrotte JG1, Franck G, Santarromana M, Nakib S, Dauchy F, Boulu RG.
"Fifty adult female Swiss albino mice were injected with either 1.11 mg/kg body weight pyridoxine or saline, subsequently they were all submitted to an immobilization stress with a complete fast for 17 h."
"In the stressed animals, the average number of gastric ulcers per mouse was twice as large in the saline-treated group than in the pyridoxine-treated group (p < 0.05)."
"Brain norepinephrine content was almost identical in fasting controls and in stressed mice treated with pyridoxine; in the stressed animals treated with saline, the average norepinephrine content was higher by 15% and in the fed controls lower by 11% than in the two preceding groups. Pyridoxine treatment entailed a very significant reduction (p < 0.002) of norepinephrine variability, mainly due to the absence of high values (> or = 750 ng/g of fresh brain) which occurred only in the saline-treated group."
"These results suggest the antistress effect of pyridoxine."
